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2-Amino-5-chlorobenzotrifluoride

2-Amino-5-chlorobenzotrifluoride structure

CAS No.: 445-03-4

Chemical Name:: 2-Amino-5-chlorobenzotrifluoride

Synonyms: FA-1-1;C.I. 37055;Scarlet Salt NVD;5-Chloro-2-amino;AKOS BBS-00003624;TIMTEC-BB SBB000345;Fast Scarlet VD Salt;Fast Scarlet Base VD;Fast Scarlet Salt VD;5-Chloro-2-aminobenz

CBNumber:: CB5217469

Molecular Formula:: C7H5ClF3N

Molecular Weight:: 195.57

MDL Number:: MFCD00007841

MOL File:: 445-03-4.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:58:13

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2-Amino-5-chlorobenzotrifluoride Properties

Melting point	8.8 °C
Boiling point	66-67 °C3 mm Hg(lit.)
Density	1.386 g/mL at 25 °C(lit.)
vapor pressure	48.5-1013hPa at 110.5-208.2℃
refractive index	n20/D 1.507(lit.)
Flash point	203 °F
storage temp.	2-8°C
pka	0.83±0.10(Predicted)
form	clear liquid
color	Colorless to Orange to Green
Specific Gravity	1.386
PH	7.4 at 20℃ and 995mg/L
BRN	2366801
InChI	1S/C7H5ClF3N/c8-4-1-2-6(12)5(3-4)7(9,10)11/h1-3H,12H2
InChIKey	CVINWVPRKDIGLL-UHFFFAOYSA-N
SMILES	Nc1ccc(Cl)cc1C(F)(F)F
LogP	2.68
CAS DataBase Reference	445-03-4(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 4-chloro-2-(trifluoromethyl)-(445-03-4)
EPA Substance Registry System	4-Chloro-2-(trifluoromethyl)aniline (445-03-4)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H335-H373

Precautionary statements

P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P314

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-33-36/37/38-41-22

Safety Statements

26-36-37/39

RIDADR

UN 2810

WGK Germany

Hazard Note

Irritant

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

III

HS Code

29214300

Storage Class

10 - Combustible liquids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT RE 2
STOT SE 3

REACH Registrations

Active

NFPA 704

	2
2		0

2-Amino-5-chlorobenzotrifluoride price More Price(62)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	217727	4-Chloro-2-(trifluoromethyl)aniline 97%	445-03-4	25g	$59.1	2026-04-30	Buy
TCI Chemical	A1058	2-Amino-5-chlorobenzotrifluoride >98.0%(GC)	445-03-4	25g	$21	2026-04-30	Buy
TCI Chemical	A1058	2-Amino-5-chlorobenzotrifluoride >98.0%(GC)	445-03-4	500g	$159	2026-04-30	Buy
TRC	TRC-A445035-5G	2-Amino-5-chlorobenzotrifluoride	445-03-4	5g	$91	2026-06-03	Buy
TRC	TRC-A445035-10G	2-Amino-5-chlorobenzotrifluoride	445-03-4	10g	$164	2026-06-03	Buy

Product number	Packaging	Price	Buy
217727	25g	$59.1	Buy
A1058	25g	$21	Buy
A1058	500g	$159	Buy
TRC-A445035-5G	5g	$91	Buy
TRC-A445035-10G	10g	$164	Buy

2-Amino-5-chlorobenzotrifluoride Chemical Properties, Uses, Production

Chemical Properties

Clear yellow liquid

Uses

2-Amino-5-chlorobenzotrifluoride is a biologically active compound and useful building block. It can be transformed into a variety of valuable fluorine-containing molecules and heterocyclic compounds.

Uses

4-Chloro-2-(trifluoromethyl)aniline was used in the synthesis of 2-amino-5-chloro 3-(trifluoromethyl)benzenethiol.

Preparation

Preparationofthechromophore : 4-Chloro-2-(trifluoromethyl)benzenammeand 4-Chloro-1-nitro-2-(trifluoromethyl)benzene reduction.

General Description

Fourier-transform (FT) infrared and FT-Raman spectra of 4-chloro-2-(trifluoromethyl) aniline has been studied.

Synthesis

1-TrifluoroMethyl-1,2-benziodoxol-3(1H)-one

887144-94-7

106-47-8

445-03-4

The general procedure for synthesizing 2-amino-5-chlorobenzotrifluoride from 1-(trifluoromethyl)-1,2-phenyliodonyl-3(1H)-one and 4-chloroaniline is as follows: in this embodiment, p-chloroaniline was used as the aromatic amine, and the rest of the reaction and post-processing steps were the same as in Example 28. The specific reaction conditions were as follows: 1-(trifluoromethyl)-1,2-phenyliodono-3(1H)-one (0.5 mmol, 1.0 eq.), 4-chloroaniline (1.5 mmol, 3.0 eq.), nickel hydroxide (10 μmol), and potassium carbonate (1.5 mmol, 3.0 eq.) were dissolved in DMSO (2 mL), and the reaction was carried out for 2 hr. at 35 °C. After the reaction was completed, the product was isolated and purified according to the post-processing procedure in Example 1.

References

[1] Organic Letters, 2018, vol. 20, # 13, p. 3732 - 3735
[2] Patent: CN108503552, 2018, A. Location in patent: Paragraph 0190-0194
[3] Organic Letters, 2014, vol. 16, # 6, p. 1768 - 1771

2-Amino-5-chlorobenzotrifluoride Preparation Products And Raw materials

Raw materials

Benzotrifluoride Sodium chloride Chlorine 3-Chlorobenzotrifluoride 1-TrifluoroMethyl-1,2-benziodoxol-3(1H)-one

5-Chloro-2-nitrobenzotrifluoride Trifluoromethyl iodide 4-Chloroaniline Potassium carbonate Nickel(II) hydroxide

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Preparation Products

2-Amino-5-fluorobenzotrifluoride Tracid Red 2bs 2-Aminobenzotrifluoride

2-Amino-5-chlorobenzotrifluoride Suppliers

Global Suppliers ( 434)

Supplier	Tel	Email	Country	ProdList	Advantage
iFar Chemical Technology	0086-510-83488850	sales@ifar.com.cn	China	49	50
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	13396369453 18678026865	sdfantai@163.com	China	904	58
Fuxin Xin Kaida Fluorine Chemistry Co., Ltd.	0418-6566789 13464830066	sales@xkdchem.com	China	174	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44852	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56

Supplier	Advantage
iFar Chemical Technology	50
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd.	58
Fuxin Xin Kaida Fluorine Chemistry Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
future industrial shanghai co., ltd	65
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56

View Latest Price from 2-Amino-5-chlorobenzotrifluoride manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	2-Amino-5-chlorobenzotrifluoride 445-03-4	$10.00	1KG	99.%	10 ton	Hebei Chuanghai Biotechnology Co,.LTD
2025-06-20	2-Amino-5-chlorobenzotrifluoride 445-03-4		1kg	99%	100tons	Hebei Yanxi Chemical Co., Ltd.
2024-04-27	4-Chloro-2-(trifluoromethyl)aniline 445-03-4	$10.00	1kg	99.6%	100000	Ouhuang Engineering Materials (Hubei) Co., Ltd

2-Amino-5-chlorobenzotrifluoride
445-03-4
$10.00
99.%
Hebei Chuanghai Biotechnology Co,.LTD

2-Amino-5-chlorobenzotrifluoride
445-03-4
99%
Hebei Yanxi Chemical Co., Ltd.

4-Chloro-2-(trifluoromethyl)aniline
445-03-4
$10.00
99.6%
Ouhuang Engineering Materials (Hubei) Co., Ltd

2-Amino-5-chlorobenzotrifluoride Spectrum

2-Amino-5-chlorobenzotrifluoride(445-03-4)MS 2-Amino-5-chlorobenzotrifluoride(445-03-4)¹HNMR 2-Amino-5-chlorobenzotrifluoride(445-03-4)¹³CNMR 2-Amino-5-chlorobenzotrifluoride(445-03-4)IR1 2-Amino-5-chlorobenzotrifluoride(445-03-4)Raman

445-03-4 (2-Amino-5-chlorobenzotrifluoride) Related Search:

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2-Amino-5-chlorobenzotrifluoride 97% 2-Amino-5-chlorobenzotrifluoride97% 4-Chlor-alpha,alpha,alpha-trifluor-o-toluidin 2-Amino-5-chlorobenzotrifluoride, 4-Chloro-α,α,α-trifluoro-o-toluidine Benzenamine, 2-trifluoromethyl-4-chloro Diazo Fast Scarlet VDA Fast Scarlet Base VD FA-1-1 Fast Scarlet VD Salt o-Toluidine, 4-chloro-alpha,alpha,alpha-trifluoro- Scarlet Salt NVD TIMTEC-BB SBB000345 Aniline,4-chloro-2-trifluoromethyl- Benzenamine,4-chloro-2-(trifluoromethyl)- C.I. 37055 C.I. Azoic Diazo Component 17 Diazo Fast Scarlet VD Fast Scarlet Salt VD 4-chloro-2-(trifluoromethyl)-benzenamin 5-Chloro-2-aminobenzotrifluoride 4-Chloro-2-(trifluoromethyl)aniline,2-Amino-5-chlorobenzotrifluoride, 4-Chloro-α,α,α-trifluoro-o-toluidine 5-Chloro-2-aminobenz 4-Chloro-2-(trifluoromethyl)aniline, 4-Chloro-alpha,alpha,alpha-trifluoro-o-toluidine 5 - chloro - 2 - aMino toluene three fluorine 4-Chloro-2-(trifluoromethyl)aniline 97% 4-Chloro-2-(trifluoromethyl)benzenamine 1-AMINO-4-CHLORO-2-(TRIFLUORMETHYL)-BENZENE 5-Chloro-2-amino 2-TRIFLUOROMETHYL-4-CHLORO-ANILINE 2-AMINO-5-CHLOROBENZOTRIFLUORIDE 2-AMINO-5-CHLORO-TRIFLUOROTOLUENE AKOS BBS-00003624 5-CHLORO-2-AMINOTRIFLUOROMETHYL BENZENE 5-CHLORO-2-AMINO TRIFLUORO TOLUENE LABOTEST-BB LT02085311 4-CHLORO-2-TRIFLUOROMETHYLANILINE 4-CHLORO-ALPHA,ALPHA,ALPHA-TRIFLUORO-O-TOLUIDINE Triflumizole Metabolite FA-1-1 Triflumizole Metabolite FA-1-1 Standard 2-Amino-5-chlorobenzotrifluoride > 2-amino-5-chlorobenzene trifluoro 4-Chloro-2-trifluoromethyl-phenylamine 2-Amino-5-chlorobenzotrifluoride ISO 9001：2015 REACH Azoic Diazo Component 17 C.I.Azoic Diazo Component 17:C.I.37055 4-chloro-α,α,α-trifluoro-o-toluidine 4-Chloro-2-(trifluoromethyl)aniline - [C72169] 4-Chloro-2-(trifluoromethyl)benzenamme 445-03-4 C7 Amines Building Blocks Organic Building Blocks Nitrogen Compounds API Intermediate Aromatic Halides (substituted) 445-03-4