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3-Mercapto-1,2-propanediol

3-Mercapto-1,2-propanediol Structure
3-Mercapto-1,2-propanediol structure
CAS No.
96-27-5
Chemical Name:
3-Mercapto-1,2-propanediol
Synonyms
MONOTHIOGLYCEROL;1-THIOGLYCEROL;THIOGLYCEROL;ALPHA-THIOGLYCEROL;3-Mercaptopropane-1,2-diol;1-Mercaptoglycerol;THIOGLYCERIN;1-Monothioglycerol;A-MONOTHIOGLYCEROL;1-Mercapto-2,3-propanediol
CBNumber:
CB5325331
Molecular Formula:
C3H8O2S
Molecular Weight:
108.16
MDL Number:
MFCD00004879
MOL File:
96-27-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 04:48:10
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3-Mercapto-1,2-propanediol Properties

Melting point <25 °C
Boiling point 118 °C5 mm Hg(lit.)
Density 1.25 g/mL at 25 °C(lit.)
vapor pressure <1 hPa (20 °C)
refractive index n20/D 1.527(lit.)
Flash point >230 °F
storage temp. 2-8°C
solubility absolute ethanol: 1 mL/mL
form liquid
pka pK1:9.43 (25°C,μ=0.5)
color Clear colorless to yellow
Odor Stench odour
PH 3.5-7.0
biological source synthetic (organic)
Water Solubility slightly soluble
Sensitive Air Sensitive & Hygroscopic
Merck 14,9335
BRN 1732046
Stability Air Sensitive, Hygroscopic
Cosmetics Ingredients Functions DEPILATORY
KERATOLYTIC
HAIR WAVING OR STRAIGHTENING
REDUCING
InChI 1S/C3H8O2S/c4-1-3(5)2-6/h3-6H,1-2H2
InChIKey PJUIMOJAAPLTRJ-UHFFFAOYSA-N
SMILES OCC(O)CS
LogP -0.84 at 20℃
CAS DataBase Reference 96-27-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII AAO1P0WSXJ
NIST Chemistry Reference Monothioglycerol(96-27-5)
EPA Substance Registry System 1,2-Propanediol, 3-mercapto- (96-27-5)
UNSPSC Code 12352211
NACRES NA.75

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H302-H311-H315-H317
Precautionary statements  P280-P301+P312+P330-P302+P352+P312
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,Xi
Risk Statements  21/22-36/37/38
Safety Statements  26-36-23
RIDADR  UN 2810 6.1/PG 3
WGK Germany  3
RTECS  TY8140000
F  3-9-10-13-23
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  III
HS Code  29309070
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 4 Oral
Skin Irrit. 2
Skin Sens. 1B
Hazardous Substances Data 96-27-5(Hazardous Substances Data)
REACH Registrations Active
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
1
2 1

3-Mercapto-1,2-propanediol price More Price(68)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.41705 3-Mercapto-1,2-propanediol for synthesis 96-27-5 10 mL $54.5 2026-04-30 Buy
Sigma-Aldrich 8.41705 3-Mercapto-1,2-propanediol for synthesis 96-27-5 50mL $132 2026-04-30 Buy
Sigma-Aldrich 8.41705 3-Mercapto-1,2-propanediol for synthesis 96-27-5 250ML $357 2026-04-30 Buy
Sigma-Aldrich 8.41705 3-Mercapto-1,2-propanediol for synthesis 96-27-5 1L $643 2026-04-30 Buy
TCI Chemical T3843 1-Thioglycerol [for Electrophoresis] min. 95.0 % 96-27-5 5G $17 2026-04-30 Buy
Product number Packaging Price Buy
8.41705 10 mL $54.5 Buy
8.41705 50mL $132 Buy
8.41705 250ML $357 Buy
8.41705 1L $643 Buy
T3843 5G $17 Buy

3-Mercapto-1,2-propanediol Chemical Properties, Uses, Production

Description

1-Thioglycerol is a reagent used in fluorescence, spectroscopy, and microbiology techniques. Varying the concentration of 1-thioglycerol in the preparation of CdSe/CdS core-shell ultrasmall quantum dots (CS-USQDs) allows a precise way to control the size of the shell, with shell size increasing with increased concentration. It is used as a capping agent in the synthesis of nanocrystals analyzed via Raman and UV/Vis spectroscopy. Biologically, 1-thioglycerol stimulates porphyrin synthesis and increases glutamyl-tRNA reductase activity in E. coli grown in an aerobic environment. It was previously a component in hair permanents used to produce waves or curls.

Chemical Properties

clear colorless to yellowish viscous solution

Chemical Properties

Monothioglycerol occurs as a colorless or pale-yellow colored, viscous, hygroscopic liquid with a slight odor of sulfide.

Uses

It generally used as a size-regulating capping agent for nanocrystals. 1-Thioglycerol is also used in bacteriology experiments to induce the synthesis of porphyrin compounds in aerobically growing Escherichia coli. Also used to study the pH-sensitive photoluminescence of aqueous thiol-capped CdTe nanocrystals. 1-Thioglycerol is used to develop and test thiol functionalized copolymers. 1-Thioglycerol is used as a post-modification agent in the generation of non-standard peptide foldamers.Potential substitute for 2-mercaptoethanol, probe for the study of lymphocyte activation.

Uses

3-Mercapto-1,2-propanediol can be used as antioxidant preservative; reagent in analytical chemistry, cell culture research. Matrix substrate in fast atom bombardment mass spectrometry.

Uses

3-Mercapto-1,2-propanediol has been used in a study to assess the manipulation of aqueous growth of CdTe nanocrystals. It has also been used in a study that investigated the effect of surface attachment on ligand binding

Production Methods

Monothioglycerol is prepared by heating an ethanolic solution of 3- chloro-1,2-propanediol with potassium bisulfide.

Definition

ChEBI: A thiol that is glycerol in which one of the primary hydroxy groups is replaced by a thiol group.

General Description

1-Thioglycerol stimulates the synthesis of porphyrin in aerobically growing Escherichia coli. It is an inhibitor of glycerol kinase activity in vitro and in situ.

Pharmaceutical Applications

Monothioglycerol is used as an antioxidant in pharmaceutical formulations, mainly in parenteral preparations.Monothioglycerol is reported to have some antimicrobial activity.It is also widely used in cosmetic formulations such as depilating agents.
Therapeutically, monothioglycerol has been used in a 0.02% w/w aqueous solution to stimulate wound healing, and as a 0.1% w/w jelly in atrophic rhinitis.

Safety Profile

Poison by intraperitoneal and intravenous routes. Experimental reproductive effects. Mutation data reported. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits hghly toxic fumes of SOx.

Safety

Monothioglycerol is generally regarded as a relatively nontoxic and nonirritant material at the concentrations used as a pharmaceutical excipient. It is used in topical and injectable preparations. Undiluted monothioglycerol is considered a poison by the IP and IV routes; it has also been reported to be mutagenic.
LD50 (cat, IV): 0.22 g/kg
LD50 (mouse, IP): 0.34 g/kg
LD50 (rabbit, IV): 0.25 g/kg
LD50 (rat, IP): 0.39 g/kg

storage

Monothioglycerol is unstable in alkaline solutions. Monothioglycerol should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Monothioglycerol can react with oxidizing materials.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM, IV and other injections). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

References

[1] ANIELLE CHRISTINE A. SILVA. Shell Thickness Modulation in Ultrasmall CdSe/CdSxSe1–x/CdS Core/Shell Quantum Dots via 1-Thioglycerol[J]. ACS Nano, 2014, 8 2: 1913-1922. DOI: 10.1021/nn406478f
[2] YANFEI WANG. Raman scattering study of molecules adsorbed on ZnS nanocrystals[J]. Journal of Raman Spectroscopy, 2006, 38 1: 34-38. DOI: 10.1002/jrs.1570
[3] M. T. HARRISON. Wet Chemical Synthesis of Highly Luminescent HgTe/CdS Core/Shell Nanocrystals[J]. Advanced Materials, 1999, 12 2: 123-125. DOI: 10.1002/(sici)1521-4095(200001)12:2<123::aid-adma123>3.0.co;2-h
[4] G T JAVOR  E F F. Enzymatic basis of thiol-stimulated secretion of porphyrins by Escherichia coli.[J]. Journal of Bacteriology, 1992, 174 3: 1072-1075. DOI: 10.1128/jb.174.3.1072-1075.1992
[5] LEHMAN A J. HEALTH ASPECTS OF COMMON CHEMICALS USED IN HAIR-WAVING PREPARATIONS[J]. JAMA neurology, 1949, 27 7 1: 842-845. DOI: 10.1001/jama.1949.62910120002010

3-Mercapto-1,2-propanediol Preparation Products And Raw materials

Raw materials

Glycerol Impurity (Disulfide Oxidation Product) Glycidol Thioacetic acid 3-Chloro-1,2-propanediol

Preparation Products

3-Mercapto-1,2-propanediol Suppliers

Global Suppliers ( 407)
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 029-81154043 17391733319 1086@dideu.com China 9966 58
Luofu Pharmaceutical Technology (Jiaxing) Co., Ltd 17621761986 bd@luofupharm.com China 130 58
Hubei Shiteng Chemical Technology Co. LTD 19086915685 18971850150 1273131441@qq.com China 4993 58
Cato Research Chemicals Inc. 020-81960175-877 18933936954 tianwen.zhan@cato-chem.com China 7335 58
Guangzhou Dreampharm Biotechnology Co., Ltd. 020-36607679; 13502246435 3008233746@qq.com China 9968 12
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9409 55
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 58
Luofu Pharmaceutical Technology (Jiaxing) Co., Ltd 58
Hubei Shiteng Chemical Technology Co. LTD 58
Cato Research Chemicals Inc. 58
Guangzhou Dreampharm Biotechnology Co., Ltd. 12
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Beijing HwrkChemical Technology Co., Ltd 55

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View Latest Price from 3-Mercapto-1,2-propanediol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Mercapto-1,2-propanediol pictures 2026-10-18 3-Mercapto-1,2-propanediol
96-27-5
 0.99 RongNa Biotechnology Co.,Ltd
3-Mercapto-1,2-propanediol pictures 2026-06-30 3-Mercapto-1,2-propanediol
96-27-5
 1KG 99.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
monothioglycerol pictures 2026-06-30 monothioglycerol
96-27-5
 1KG 99.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

3-Mercapto-1,2-propanediol Spectrum

3-Mercapto-1,2-propanediol(96-27-5)MS3-Mercapto-1,2-propanediol(96-27-5)1HNMR3-Mercapto-1,2-propanediol(96-27-5)IR13-Mercapto-1,2-propanediol(96-27-5)Raman

96-27-5 (3-Mercapto-1,2-propanediol) Related Search:

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MERCAPTOGLYCEROL 1-Thioglycerol,α-Monothioglycerol, α-Thioglycerol, 3-Mercapto-1,2-propanediol 2,3-Dihydroxypropane-1-thiol, 3-Sulfanylpropane-1,2-diol, Mercapto glycerol, Thioglycerol 3-Thiopropane-1,2-diol, NF grade alpha-Thioglycerol  3-Mercapto-1,2-propanediol, 90 wt% aqueous solution 100ML 3-Mercapto-1,2-propanediol, 90 wt% aqueous solution 25ML 3-Thiopropane-1,2-diol 97% Thioglycerol, 3-Mercaptopropane-1,2-diol 2,3-Dihydroxypropane-1-thiol, 3-Sulphanylpropane-1,2-diol, Mercapto glycerol, Thioglycerol 1-Thioglycerol 〔3-Mercapto-1,2-Propanediol〕 α-Thioglycerol [Matrix for FABMS and liquid SIMS] 3-Mercapto-1,2-propanediol for synthesis MONOTHIOGLYCEROL, CELL CULTURE TESTED 1-THIOGLYCEROL, MATRIX SUBSTANCE FOR FAB -MS 1-THIOGLYCEROL 90 % IN WATER 1-THIOGLYCEROL, DIST. A-MONOTHIOGLYCEROL SIGMAULTRA 3-MERCAPTO-1,2-PROPANEDIOL 90 WT% AQUEOUS SOLUTION 3-MERCAPTO-1,2-PROPANEDIOL, MIN. 98%, REAGENT GRADE 1-Thioglycerol,>89% 3-Mercapto-1,2-propanediol, tech., 90% 1-THIOGLYCEROL GR 90% 3-MERCAPTO-1,2-PROPANEDIOL(1-THIOGLYCEROL)) 3-THIOGLYCEROL 3-MERCAPTO-1,2-PROPANEDIOL 90+% alpha-Thioglycerol [Matrix for FABMS and liquid SIMS] 3-MERCAPTO-1,2-PROPANEDIOL pure α-Monothioglycerol, α-Thioglycerol, 3-Mercapto-1,2-propanediol 3-Sulfanylpropane-1,2-diol Mercapto-1,2-propanediol 3-MERCAPTO-1,2-PROPANEDIOLRESEARCH GRADE ALPHA-MONOTHIOGLYCEROL 3-MERCAPTO-1,2-PROPANDIOL 3-MERCAPTO-1,2-PROPANEDIOL 1,2-Propanediol, 3-mercapto- 1-Thio-2,3-propanediol 1-Thiogylcerol 2,3-Dihydroxypropanethiol 3-mercapto-propane-1,2-diol 3-Sulfanyl-1,2-propanediol alpha-Thiolglycerol Glycerol, 1-thio- Glycerol-1-thiol Monothioglycerin Thioglycerine Thiovanol USAF B-40 USAF cb-37 rac-3-sulfanylpropane-1,2-diol Mono Thioglycerol (MTG) 3-Thiopropane-1,2-diol α-Thioglycerol[MatrixforFABMSandliquidSIMS]> α-Thioglycerol Monothioglycerol USP-NF PARENTEX 100GM Monothioglycerol USP-NF PARENTEX 500GM Monothioglycerol USP-NF PARENTEX 1KG Monothioglycerol 90% 1KG