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3-Mercapto-1,2-propanediol

3-Mercapto-1,2-propanediol
3-Mercapto-1,2-propanediol structure
CAS No.
96-27-5
Chemical Name:
3-Mercapto-1,2-propanediol
Synonyms
Thiovanol;USAF B-40;USAF cb-37;THIOGLYCEROL;THIOGLYCERIN;Thioglycerine;3-THIOGLYCEROL;1-Thiogylcerol;1-THIOGLYCEROL;Glycerol-1-thiol
CBNumber:
CB5325331
Molecular Formula:
C3H8O2S
Formula Weight:
108.16
MOL File:
96-27-5.mol

3-Mercapto-1,2-propanediol Properties

Melting point:
<25 °C
Boiling point:
118 °C5 mm Hg(lit.)
Density 
1.25 g/mL at 25 °C(lit.)
vapor pressure 
<1 hPa (20 °C)
refractive index 
n20/D 1.527(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
absolute ethanol: 1 mL/mL
form 
liquid
pka
pK1:9.43 (25°C,μ=0.5)
color 
Clear colorless to yellow
PH
3.5-7.0
Water Solubility 
slightly soluble
Sensitive 
Air Sensitive & Hygroscopic
Merck 
14,9335
BRN 
1732046
InChIKey
PJUIMOJAAPLTRJ-UHFFFAOYSA-N
CAS DataBase Reference
96-27-5(CAS DataBase Reference)
NIST Chemistry Reference
Monothioglycerol(96-27-5)
EPA Substance Registry System
1,2-Propanediol, 3-mercapto- (96-27-5)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS07
Signal word  Danger
Hazard statements  H302-H311-H315-H319-H335-H301
Precautionary statements  P264-P270-P302+P352+P312+P361+P364-P305+P351+P338+P337+P313-P405-P501-P280a-P301+P310a-P501a-P261-P280-P305+P351+P338-P312-P301+P312+P330-P302+P352+P312
Hazard Codes  Xn,Xi
Risk Statements  21/22-36/37/38
Safety Statements  26-36-23
RIDADR  UN 2810 6.1/PG 3
WGK Germany  3
RTECS  TY8140000
3-9-10-13-23
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29309070

3-Mercapto-1,2-propanediol price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 56454 1-Thioglycerol 97.0-101.0% (calc. on anhydrous basis, T) 96-27-5 50g $613 2019-12-02 Buy
Sigma-Aldrich 56454 1-Thioglycerol 97.0-101.0% (calc. on anhydrous basis, T) 96-27-5 500g $2144 2019-12-02 Buy
TCI Chemical S0374 alpha-Thioglycerol [Matrix for FABMS and liquid SIMS] >98.0%(GC)(T) 96-27-5 1g $22 2019-12-02 Buy
TCI Chemical S0374 alpha-Thioglycerol [Matrix for FABMS and liquid SIMS] >98.0%(GC)(T) 96-27-5 10g $97 2019-12-02 Buy
Alfa Aesar A18948 3-Mercapto-1,2-propanediol, 90+% 96-27-5 50g $41.4 2019-12-02 Buy

3-Mercapto-1,2-propanediol Chemical Properties,Uses,Production

Chemical Properties

clear colorless to yellowish viscous solution

Chemical Properties

Monothioglycerol occurs as a colorless or pale-yellow colored, viscous, hygroscopic liquid with a slight odor of sulfide.

Uses

3-Mercapto-1,2-propanediol has been used in a study to assess the manipulation of aqueous growth of CdTe nanocrystals. It has also been used in a study that investigated the effect of surface attachment on ligand binding

Uses

3-Mercapto-1,2-propanediol can be used as antioxidant preservative; reagent in analytical chemistry, cell culture research. Matrix substrate in fast atom bombardment mass spectrometry.

Definition

ChEBI: A thiol that is glycerol in which one of the primary hydroxy groups is replaced by a thiol group.

Production Methods

Monothioglycerol is prepared by heating an ethanolic solution of 3- chloro-1,2-propanediol with potassium bisulfide.

Pharmaceutical Applications

Monothioglycerol is used as an antioxidant in pharmaceutical formulations, mainly in parenteral preparations.Monothioglycerol is reported to have some antimicrobial activity.It is also widely used in cosmetic formulations such as depilating agents.
Therapeutically, monothioglycerol has been used in a 0.02% w/w aqueous solution to stimulate wound healing, and as a 0.1% w/w jelly in atrophic rhinitis.

Safety Profile

Poison by intraperitoneal and intravenous routes. Experimental reproductive effects. Mutation data reported. Flammable when exposed to heat or flame; can react with oxidizing materials. When heated to decomposition it emits hghly toxic fumes of SOx.

Safety

Monothioglycerol is generally regarded as a relatively nontoxic and nonirritant material at the concentrations used as a pharmaceutical excipient. It is used in topical and injectable preparations. Undiluted monothioglycerol is considered a poison by the IP and IV routes; it has also been reported to be mutagenic.
LD50 (cat, IV): 0.22 g/kg
LD50 (mouse, IP): 0.34 g/kg
LD50 (rabbit, IV): 0.25 g/kg
LD50 (rat, IP): 0.39 g/kg

storage

Monothioglycerol is unstable in alkaline solutions. Monothioglycerol should be stored in a well-closed container in a cool, dry place.

Incompatibilities

Monothioglycerol can react with oxidizing materials.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM, IV and other injections). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

3-Mercapto-1,2-propanediol Preparation Products And Raw materials

Raw materials

Preparation Products


3-Mercapto-1,2-propanediol Suppliers

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3-Mercapto-1,2-propanediol Spectrum


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