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Analysis reagents Purification method Chemical properties Uses Production method Category Toxicity grading Acute toxicity Irritation data Explosive hazardous properties Flammability hazard characteristics Storage characteristics Extinguishing agent
Chemical Name:
Molecular Formula:
Formula Weight:
MOL File:

Cupferron Properties

Melting point:
150-155 °C (dec.)(lit.)
Boiling point:
278.95°C (rough estimate)
1.3092 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
Water Solubility 
<0.1 g/100 mL at 18.5 ºC
Stable, but may be moisture sensitive. Incompatible with strong oxidizing agents, strong bases, strong acids.
CAS DataBase Reference
135-20-6(CAS DataBase Reference)
NIST Chemistry Reference
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  25-36/37/38-40-45-43-23/24/25
Safety Statements  26-36/37-45-53
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  NC4725000
HazardClass  6.1
PackingGroup  III
Hazardous Substances Data 135-20-6(Hazardous Substances Data)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P309 IF exposed or if you feel unwell:
P310 Immediately call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Cupferron price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 675636 Cupferron 97%, reagent grade 135-20-6 100g $199 2018-11-13 Buy
Sigma-Aldrich 675636 Cupferron 97%, reagent grade 135-20-6 500g $655 2018-11-13 Buy
TCI Chemical C0646 Cupferron >98.0%(HPLC)(T) 135-20-6 25g $29 2017-11-08 Buy
TCI Chemical C0646 Cupferron >98.0%(HPLC)(T) 135-20-6 500g $261 2017-11-08 Buy
Alfa Aesar 042954 Cupferron 135-20-6 50g $49.9 2018-11-16 Buy

Cupferron Chemical Properties,Uses,Production

Analysis reagents

Cupferron is an important analytical reagent, as Ammonium salt of N-nitroso hydroxylamine, commonly known as cupferron. It is usually white or light yellow bright flake scrystal, with sweet odour, long home to darken due to slow decomposition, but in fact can also be used in the analysis. It is soluble in water, benzene, alcohol, ether. The reagent is thermally decomposed to prepare nitrobenzene. Unstable in light and air, we need to save itin a brown reagent grinding mouth bottle, usually place a small amount of ammonium carbonate in bottle packaged with paper or cloth good as a preservative, store in a sealed dark cool place. It can be used as a precipitating agent and solvent extraction agent of copper, iron, tin, titanium, vanadium, chromium and other elements, as a masking agent for the determination of rare earth.
Nitrobenzene is reduced with zinc powder in an aqueous solution of ammonium chloride to get phenylhydroxylamine, which is then dissolved in ether, lead to excessive ammonia, and addn-butyl nitrite, then get cupferron, can form a stable five-membered ring chelate with metal ions, therefore, it is common organic precipitant. It can quantitatively measure Fe3 + ions in the acid solution, can also be measure Cu2 +, Sn4 +, Ti4 +, Ga3 +, Hf4 +and other ions, and vanadate (VO-3, VO3-3). When Fe3 +, Cu2 + ions mixedwith other metal ions together, the reagent can be used to separate them out. It is a chelating extractant for Al3 +, Au3 +, Be2 +, Co2 +, La3 +, Pu4 + and other ions, a masking agent for rare earth metal ions.
The above information is edited by the chemicalbook of Yan Yanyong.

Purification method

Ddd 30g powdered crude into 120ml60 ℃ water, make it all dissolved, add 2g of powdered activated carbon and stir for 10~15min, filtrate with the calcined Buchner, and cool the filtrate to 10~15 ℃, then cool to 0 ℃ overnight. Suction filtration by using a glass filter to precipitate crystals, wash with 10ml ethanol and then wash with 10ml of ether, and dry in air.
Cupferron can also be recrystallized with ethanol to purify.

Chemical properties

It is white or cream colored flaky crystals. Melting point is 163-164 ℃, it is soluble in water and alcohol.


1. Cupferron is used for quantitative analysis for aluminum, zinc, copper, iron, gallium, mercury, manganese, niobium, tin, tantalum, thorium, titanium, vanadium, zirconium and other elements
2. It is used as polymerization inhibitor, due to unique polymerization inhibition characteristics of cupferron, also the amount is small, can be used as an alternative of phenol polymerization inhibitor BHT, which is current largely applicated.
3. Cupferron is used for colorimetric determination for the weight of aluminum, bismuth, copper, iron, mercury, zinc, manganese, niobium, gallium, tantalum, thorium, titanium, vanadium, tin and other elements of. It is used for quantitative determination of iron in the strong acid solution, quantitative analysis of vanadate, separation of copper and iron together with the other metals, as a masking agent for measuring rare earths.

Production method

Benzene hydroxylamine ether solution was cooled in an ice bath, lead to an excess of ammonia, while stirring and continue adding the ammonia, solution of n-butyl nitrite was added for about 1h, then stir for 15min. Filter precipitate of cupferron, wash with diethyl ether, dry to get products. The product should be stored in a brown glass bottle, the bottle is placed a small amount of ammonium carbonate wrapped by paper (or cloth) as a stabilizer.



Toxicity grading

highly toxic

Acute toxicity

oral-rat LD 50: 199 mg/kg, intravenous-Mouse LD50: 180 mg/kg

Irritation data

Eye-rabbit 20 mg/24 hours moderate

Explosive hazardous properties

Explosive with thorium salt, zirconium salt or titanium salt solution at room temperature

Flammability hazard characteristics

It produces toxic fumes of nitrogen oxides and ammonia at high temperature.

Storage characteristics

Treasury ventilation, low-temperature drying

Extinguishing agent

Dry powder, foam, sand, carbon dioxide, water mist

Chemical Properties

white to light yellow crystalline powder


As a reagent for separating Sn from Zn, and Cu and Fe from other metals. Ppts iron quantitatively from strongly acid solution; as a quantitative reagent for vanadates with which it gives a dark-red ppt soluble in alkali solution, and for Ti with which it forms a yellow ppt; also suitable for the colorimetric estimation of Al.

General Description

Light yellow or cream-colored crystals or a brown crystalline solid. As a reagent in the separation of copper and iron.

Air & Water Reactions

Hygroscopic. Soluble in water.

Reactivity Profile

Cupferron may be sensitive to prolonged exposure to air. Incompatible with strong oxidizing agents, strong acids and strong bases. Forms unstable solutions with thorium, titanium and zirconium salts.

Fire Hazard

Flash point data for Cupferron are not available; however, Cupferron is probably combustible.

Purification Methods

Recrystallise it twice from EtOH after treatment with Norite and finally once with EtOH. The crystals are washed with diethyl ether and air dried, then stored in the dark over solid ammonium carbonate. A standard solution (ca 0.05M prepared in air-free H2O) is prepared daily from this material for analytical work and is essentially 100% pure. [Olsen & Elving Anal Chem 26 1747 1954.] It can also be washed with Et2O, dried and stored as stated. In a sealed, dark container it can be stored for at least 12 months without deterioration. 260nm (CHCl3). max [Marvel Org Synth Coll Vol I 177 1941, Elving & Olson J Am Chem Soc 78 4206 1956, Beilstein 16 IV 891.] Possible CARCINOGEN.

Cupferron Preparation Products And Raw materials

Raw materials

Preparation Products

Cupferron Suppliers

Global( 177)Suppliers
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Shanghai Bojing Chemical Co.,Ltd.
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Mainchem Co., Ltd.
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Shanghai Boer Chemical Reagents Co.,Ltd +86-21-33050930
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