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Hydroxocobalamin

Uses
Hydroxocobalamin
Hydroxocobalamin structure
CAS No.
13422-51-0
Chemical Name:
Hydroxocobalamin
Synonyms
axlon;axion;ohb12;cobalex;docclan;docelan;vibeden;docevita;duradoce;hydrovit
CBNumber:
CB6133733
Molecular Formula:
C62H90ClCoN13O15P
Formula Weight:
1382.82
MOL File:
13422-51-0.mol

Hydroxocobalamin Properties

Melting point:
>300 °C
storage temp. 
2-8°C
solubility 
methanol: 10 mg/mL at 20 °C, clear, dark red
form 
neat
FDA UNII
Q40X8H422O
ATC code
B03BA03,B03BA53,V03AB33
EPA Substance Registry System
Cobinamide, Co-hydroxy-, f-(dihydrogen phosphate), inner salt, 3'-ester with (5,6-dimethyl-1-.alpha.-D-ribofuranosyl-1H-benzimidazole-.kappa.N3) (13422-51-0)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  GG3820000
3-8-10
Toxicity LD50 intravenous in mouse: > 50mg/kg

Hydroxocobalamin price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H7126 Vitamin B12a hydrochloride analytical standard 13422-51-0 100 mg $83.3 2021-03-22 Buy
Sigma-Aldrich 95200 Vitamin B12a hydrochloride ≥96% (UV), ≥96% (HPLC) 13422-51-0 250 mg $90.1 2021-03-22 Buy
Sigma-Aldrich H1428000 Hydroxocobalamin European Pharmacopoeia (EP) Reference Standard 13422-51-0 h1428000 $190 2020-08-18 Buy
Sigma-Aldrich H1428000 Hydroxocobalamin European Pharmacopoeia (EP) Reference Standard 13422-51-0 $190 2021-03-22 Buy
Sigma-Aldrich H7126 Vitamin B12a hydrochloride analytical standard 13422-51-0 1 g $192 2021-03-22 Buy

Hydroxocobalamin Chemical Properties,Uses,Production

Uses

Hydroxocobalamin is an intermediate in the synthesis of Nitritocobalamin is a useful synthetic intermediate in the synthesis of Hydroxocobalamin Acetate; a physiological analog of vitamin B12 where the CN group is replaced with OH. Exists in aqueous solution as an equilibrium mixture of the hydroxy isomer and the ionic aqua isomer (aquacobalamin). Precursor of the coenzymes methylcobalamin and cobamamide. Coordination Compound. Vitamin (hematopoietic).

Originator

Alpha-Redisol,MSD,US,1962

Uses

Vitamin (hematopoietic).

Definition

A form of vitamin B 12.

Manufacturing Process

A solution containing 26.3 mg of vitamin B12 in 15 ml of water was shaken with 78 mg of platinum oxide catalyst and hydrogen gas under substantially atmospheric pressure at 25°C for 20 hours. Hydrogen was absorbed. During the absorption of hydrogen the color of the solution changed from red to brown. The solution was separated from the catalyst and evaporated to dryness in vacuo. The residue was then dissolved in 1 ml of water and then diluted with about 6 ml of acetone.
After standing for several hours a small amount of precipitate (about 2 to 3 mg) was formed and was then separated from the solution. This solution was diluted with an additional 2 ml of acetone and again allowed to stand for several hours. During this time about 4 to 5 mg of noncrystalline precipitate formed. This solid was separated from the solution and an additional 2 ml of acetone was added to the solution. On standing, vitamin B12a began to crystallize in the form of red needles. After standing for 24 hours, the crystalline material was separated, yield 12 mg. By further dilution of the mother liquor with acetone additional crystalline precipitate formed (from US Patent 2,738,302).

Therapeutic Function

Hematopoietic vitamin

Hydroxocobalamin Preparation Products And Raw materials

Raw materials

Preparation Products


Hydroxocobalamin Suppliers

Global( 135)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20903 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Wuhan Boyuan Import & Export Co., LTD
+8618033787409
0311-89850048 Mike@whby-chem.com China 299 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5930 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
+86 15821988213 info@longyupharma.com China 2473 58

View Lastest Price from Hydroxocobalamin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-03 Hydroxocobalamin
13422-51-0
US $10.00 / Kg/Drum 1KG 99% 5000tons per month Wuhan Mulei New Material Technology Co. Ltd
2020-03-19 Hydroxocobalamin/Hydrovit/vitamin B12 CAS NO.13422-51-0
13422-51-0
US $1.00 / G 1G 99% 100kg/day Wuhan Boyuan Import & Export Co., LTD
2020-03-19 High purity Hydroxocobalamin
13422-51-0
US $1.00 / G 100KG 99% 50000tons Wuhan Boyuan Import & Export Co., LTD

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