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Mecobalamin

CAS No.
13422-55-4
Chemical Name:
Mecobalamin
Synonyms
METHYLCOBALAMIN;MECOBALAMINE;methylcobalamine;methycobal;Mecobalamin Tablets;vitamin B12 Mecobalamin;Mecobalamin(Methylcobalamin);Methyl-5,6-dimethylbenzimidazolylcobalamin;MeCbl;mbl-a
CBNumber:
CB1106194
Molecular Formula:
C63H90CoN13O14P
Molecular Weight:
1343.4
MDL Number:
MFCD00082483
MOL File:
13422-55-4.mol
MSDS File:
SDS
Last updated:2024-01-23 16:25:11

Mecobalamin Properties

Melting point >190°C (dec.)
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Sparingly), Water (Slightly)
pka pK1:7.64(+1) (25°C)
form Solid
color Dark Red
Odor Odorless
Water Solubility Partially soluble in cold water, hot water.
Stability Light Sensitie
InChIKey JEWJRMKHSMTXPP-WYVZQNDMSA-L
LogP -2.812 (est)
FDA 21 CFR 184.1945; 101.9; 104.20; 107.10; 107.100
CAS DataBase Reference 13422-55-4
NCI Dictionary of Cancer Terms vitamin B12
FDA UNII BR1SN1JS2W
ATC code B03BA05

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  2
RTECS  GG3745000
HS Code  29362600
Toxicity LD50 oral in rat: > 5gm/kg
NFPA 704
1
0 0

Mecobalamin price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M9756 Methylcobalamin vitamin B 13422-55-4 1g $803 2024-03-01 Buy
Sigma-Aldrich 1424550 Methylcobalamin United States Pharmacopeia (USP) Reference Standard 13422-55-4 2x150mg $447 2024-03-01 Buy
Alfa Aesar A11176 Methylcobalamin hydrate, 98+% 13422-55-4 500mg $288 2021-12-16 Buy
Alfa Aesar A11176 Methylcobalamin hydrate, 98+% 13422-55-4 100mg $73.4 2021-12-16 Buy
Cayman Chemical 29113 Methylcobalamin 13422-55-4 100mg $36 2024-03-01 Buy
Product number Packaging Price Buy
M9756 1g $803 Buy
1424550 2x150mg $447 Buy
A11176 500mg $288 Buy
A11176 100mg $73.4 Buy
29113 100mg $36 Buy

Mecobalamin Chemical Properties,Uses,Production

Pharmacological action

Mecobalamin as vitamin B12 derivatives, should be called "methyl vitamin B12" according to the chemical structure of name, the functional groups of methylation can be involved in the biochemical process of methyl transfer activity, promoting to nucleic acid of nerve tissue, the metabolism of protein and fat, , can stimulate the synthesis of lecithin Schwann cells, repairing the damaged myelin, improving nerve conduction velocity; directly into nerve cells, and stimulating axon regeneration of damaged area; stimulating protein synthesis in nerve cells and enhanced synthetic metabolism of axons to prevent axonal degeneration; involved in nucleic acid synthesis, promoted hematopoietic function. The treatment is clinically used in diabetic neuropathy, long-term use of macrovascular complications of diabetes are the curative effect.
Mecobalamin is used for peripheral nerve disorders treatment drug, compared with other vitamin B12 preparations, having good transfer on the nervous tissue, through the methyl transfer reaction, can promote nucleic acid, protein lipid metabolism, repairing the damaged nerve tissue. In homocysteine synthetic egg ammonia acid process, it plays a role of coenzyme, especially by deoxyuridine synthesis of thymidine, promoting DNA and RNA synthesis of participation. Also in the experiment of glial cells, the drugs can improve methionine synthase activity and promote the synthesis of myelin lipids lecithin. Improving the nerve tissue metabolism, can promot axis cable and protein synthesis, make the delivery rate of the skeletal protein close to normal, maintain axonal functions. Besides mecobalamin injections can inhibit nerve tissue of abnormal impulse conduction, promoting redl blood cells mature, split, improving anemia. Mecobalamin can be quickly restored due to lack of B12 and reduce the number of rat erythrocytes, hemoglobin, hematocrit value. Used for megaloblastic red blood cell anemia and peripheral nerve disorder due to the lack of vitamin B12.
The above information is edited by the Chemicalbook Hanya.

Uses

1.It is used for the treatment of nervous system diseases, relieving pain and numbness, speeded relieving pain, improving pain caused by cervical spondylosis, treatment of sudden deafness, etc.
2.Methylcobalamin is a kind of endogenous coenzyme B12, participating in the one carbon unit cycle, playing an important role in the synthesis of methionine homocysteine methyl transfer reaction process.

Description

Methylcobalamin is an analog of vitamin B12 with diverse neurological activities. It promotes neurite outgrowth and survival in primary cerebellar granule (CGN) and dorsal root ganglion (DRG) cells and activation of ERK1/2 and Akt when used at concentrations ranging from 0.1 to 100 μM. Methylcobalamin (1 mg/kg per day) improves sensory function in a pinch test and increases toe spreading in a rat model of sciatic nerve injury. It decreases the number of atypical mitochondria in the sciatic nerve and reduces mechanical allodynia and thermal hyperalgesia induced by vincristine in a rat model of neuropathic pain. Methylcobalamin (30 mg/kg) reduces muscle weakness and forelimb contracture and increases bicep muscle weight and the number of musculocutaneous nerves in the wobbler mouse model of amyotrophic lateral sclerosis (ALS). It also enhances the recovery of compound muscle action potentials and motor end plate innervation and decreases the time to sticker removal in the sticker removal grooming test in a rat model of bicep ulnar to musculocutaneous nerve transfer.

Chemical Properties

Dark Red Crystalline Powder

Physical properties

Vitamin B12 is an octahedral cobalt complex consisting of a porphyrin-like, cobalt centered macroring (called a corrin ring or nucleus). The corrinoids are red, red orange, or yellow crystalline substances that show intense absorption spectra above 300 nm owing to the π–π transitions of the corrin nucleus. They are soluble in water and are fairly stable to heat but decompose at temperatures above ~210 °C without melting.
Vitamin B12 reacts with ascorbic acid, resulting in the reduction and subsequent degradation of the former, which releases its cobalt atom as the free ion. Cobalamins are more stable in the presence of ascorbic acid but unstable to light

Uses

Histamine receptor, Alzheimer research

Uses

One of the biologically active forms of vitamin B12; differing only by the substitution of a methyl for the cyano group. Coenzyme required in the biosynthesis of methionine. Vitamin (hematopoietic).

Definition

A vitamin B 12 analog used as an intermediate in the synthesis of methane. It is responsible for the methylation of inorganic mercury by anaerobic bacteria in bottom sediments. Through the action of methylcobalamin in an anaerobic bacteria in bottom sediments of aquatic systems, arsenic(III) is methylated to methanearsonic acid then to cacodylic acid.

Side effects

Common side effects of Mecobalamin include: vomiting, diarrhoea, nausea, headache and loss of appetite. Rarely, hypotension, hypokalaemia and thrombocytosis occur. Serious allergic reactions are rare, contact your doctor if you experience hives, difficulty breathing, swelling of the face, lips, tongue or throat, difficulty breathing.

68-19-9
25596-24-1
13422-55-4
Synthesis of Mecobalamin from Vitamin B12 and TRIMETHYLSULFOXONIUM BROMIDE

Mecobalamin Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 482)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953 sales@pioneerbiotech.com China 3000 58
TAIZHOU YUXIN BIOTECHNOLOGY CO,.LTD
+86-576-88902229;+86-0576-88902229 +8613968687450 yuxin@yuxchem.com China 122 58
Hebei Mojin Biotechnology Co., Ltd
+86-13288715578 +86-13231137666 sales@hbmojin.com China 12409 58
Hebei Lingding Biotechnology Co., Ltd.
+86-18031140164 +86-19933155420 erin@hbldbiotech.com China 885 58
Henan Tengmao Chemical Technology Co. LTD
+8615238638457 salesvip2@hntmhg.com China 401 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Hangzhou ICH Biofarm Co., Ltd
+undefined8613073685410 sales@ichemie.com China 985 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21703 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9359 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070 product@chemlin.com.cn CHINA 3012 60

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View Lastest Price from Mecobalamin manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Mecobalamin pictures 2024-01-23 Mecobalamin
13422-55-4
US $110.00-90.00 / kilogram 1kilogram 99% 10 tons/per week Henan Tengmao Chemical Technology Co. LTD
Mecobalamin pictures 2023-12-05 Mecobalamin
13422-55-4
US $25.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biotechnology Co., Ltd.
Mecobalamin pictures 2023-11-01 Mecobalamin
13422-55-4
US $0.00-0.00 / kg 1kg 99.0%min 10tons Hangzhou ICH Biofarm Co., Ltd
  • Mecobalamin pictures
  • Mecobalamin
    13422-55-4
  • US $110.00-90.00 / kilogram
  • 99%
  • Henan Tengmao Chemical Technology Co. LTD
  • Mecobalamin pictures
  • Mecobalamin
    13422-55-4
  • US $25.00 / KG
  • 99%
  • Hebei Lingding Biotechnology Co., Ltd.
  • Mecobalamin pictures
  • Mecobalamin
    13422-55-4
  • US $0.00-0.00 / kg
  • 99.0%min
  • Hangzhou ICH Biofarm Co., Ltd

Mecobalamin Spectrum

MECOBALAMIN cobalt-methylcobalamin cobinamide,cobalt-methylderivative,hydroxide,dihydrogenphosphate(ester), Algobaz Hitocobamin-M MeCbl Methylcobaz METHYLCOBALAMIN(P) methylvitaminb12 MecobalaminVitaminB12Jpxiu Mecobalamin / Vitamin B12 Cobinamide, Co-methyl-, dihydrogen phosphate (ester), inner salt, 3'-ester with (5,6-dimethyl-1-α-D-ribofuranosyl-1H-benzimidazole-κN3) (9CI) innersalt,3’-esterwith5,6-dimethyl-1-alpha-d-ribofuranosylbenzimidazole mbl-a methyl-b12 methylated B12 Methylcobalamine (vitamin b12, Mecobalamin) USP grade Methylcobalamin[Mecobalamin] VitaminB12 Derivatives [5-(5,6-dimethyl-1-benzimidazolyl)-4-hydroxy-2-(hydroxymethyl)-3-oxolanyl] 1-[[1-oxo-3-[2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-oc 6-dimethylbenzimidazolylcobalamin Mecobalamin RS CH3-B12 Cobametin Vancomin Methylcobalamin-13C-d3 Mecobalamin USP/EP/BP B12 VITAMIN B12 USP/EP/BP 4-Methylcyanocobalamin MethylcobalaminQ: What is Methylcobalamin Q: What is the CAS Number of Methylcobalamin Q: What is the storage condition of Methylcobalamin Q: What are the applications of Methylcobalamin Methylcobalamin (2 x 150 mg) (1424550) MECOBALAMINE METHYLCOBALAMIN methylcobalamine Mecobalamin(Methylcobalamin) methycobal Mecobalamin Tablets Methyl-5,6-dimethylbenzimidazolylcobalamin vitamin B12 Mecobalamin Methylcobalamin vitamin B12 Methylcobalamin,inhibit,Endogenous Metabolite,Inhibitor Vitamin B12 series Methylcobalamin (Impurity) Mthylcobalamin Vitamin b12 Methylated (Methylcobalamin) 13422-55-4 C63H91CoN13O14P C63H91N13O14P C63H91CoN13 C63H91N13O14PxH2O API Pharmaceutical intermediates PHARMACEUTICALS Nutritional Supplements Intermediates & Fine Chemicals Vitamin B12 Nutrition Research Vitamins