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Mecobalamin

Pharmacological action Uses
Mecobalamin
Mecobalamin structure
CAS No.
13422-55-4
Chemical Name:
Mecobalamin
Synonyms
MeCbl;mbl-a;Algobaz;CH3-B12;Vancomin;Cobametin;methycobal;methyl-b12;Methylcobaz;Vitamin B12
CBNumber:
CB1106194
Molecular Formula:
C63H91CoN13O14P
Formula Weight:
1344.38
MOL File:
13422-55-4.mol

Mecobalamin Properties

Melting point:
>190°C (dec.)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
pka
pK1:7.64(+1) (25°C)
Water Solubility 
Partially soluble in cold water, hot water.
InChIKey
JEWJRMKHSMTXPP-WYVZQNDMSA-L
CAS DataBase Reference
13422-55-4
FDA 21 CFR
184.1945; 101.9; 104.20; 107.10; 107.100
NCI Dictionary of Cancer Terms
vitamin B12
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  2
RTECS  GG3745000
HS Code  29362600
Toxicity LD50 oral in rat: > 5gm/kg

Mecobalamin price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich V2876 Vitamin B12 ≥98% 13422-55-4 100 mg $47.4 2021-03-22 Buy
Sigma-Aldrich V6629 Vitamin B12 BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98% 13422-55-4 100 mg $47.9 2021-03-22 Buy
Sigma-Aldrich V2876 Vitamin B12 ≥98% 13422-55-4 250 mg $59.9 2021-03-22 Buy
Sigma-Aldrich V6629 Vitamin B12 BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98% 13422-55-4 250 mg $62.4 2021-03-22 Buy
Sigma-Aldrich V2876 Vitamin B12 ≥98% 13422-55-4 500 mg $77.4 2021-03-22 Buy

Mecobalamin Chemical Properties,Uses,Production

Pharmacological action

Mecobalamin as vitamin B12 derivatives, should be called "methyl vitamin B12" according to the chemical structure of name, the functional groups of methylation can be involved in the biochemical process of methyl transfer activity, promoting to nucleic acid of nerve tissue, the metabolism of protein and fat, , can stimulate the synthesis of lecithin Schwann cells, repairing the damaged myelin, improving nerve conduction velocity; directly into nerve cells, and stimulating axon regeneration of damaged area; stimulating protein synthesis in nerve cells and enhanced synthetic metabolism of axons to prevent axonal degeneration; involved in nucleic acid synthesis, promoted hematopoietic function. The treatment is clinically used in diabetic neuropathy, long-term use of macrovascular complications of diabetes are the curative effect.
Mecobalamin is used for peripheral nerve disorders treatment drug, compared with other vitamin B12 preparations, having good transfer on the nervous tissue, through the methyl transfer reaction, can promote nucleic acid, protein lipid metabolism, repairing the damaged nerve tissue. In homocysteine synthetic egg ammonia acid process, it plays a role of coenzyme, especially by deoxyuridine synthesis of thymidine, promoting DNA and RNA synthesis of participation. Also in the experiment of glial cells, the drugs can improve methionine synthase activity and promote the synthesis of myelin lipids lecithin. Improving the nerve tissue metabolism, can promot axis cable and protein synthesis, make the delivery rate of the skeletal protein close to normal, maintain axonal functions. Besides mecobalamin injections can inhibit nerve tissue of abnormal impulse conduction, promoting redl blood cells mature, split, improving anemia. Mecobalamin can be quickly restored due to lack of B12 and reduce the number of rat erythrocytes, hemoglobin, hematocrit value. Used for megaloblastic red blood cell anemia and peripheral nerve disorder due to the lack of vitamin B12.
The above information is edited by the Chemicalbook Hanya.

Uses

1.It is used for the treatment of nervous system diseases, relieving pain and numbness, speeded relieving pain, improving pain caused by cervical spondylosis, treatment of sudden deafness, etc.
2.Methylcobalamin is a kind of endogenous coenzyme B12, participating in the one carbon unit cycle, playing an important role in the synthesis of methionine homocysteine methyl transfer reaction process.

Chemical Properties

Dark Red Crystalline Powder

Physical properties

Vitamin B12 is an octahedral cobalt complex consisting of a porphyrin-like, cobalt centered macroring (called a corrin ring or nucleus). The corrinoids are red, red orange, or yellow crystalline substances that show intense absorption spectra above 300 nm owing to the π–π transitions of the corrin nucleus. They are soluble in water and are fairly stable to heat but decompose at temperatures above ~210 °C without melting.
Vitamin B12 reacts with ascorbic acid, resulting in the reduction and subsequent degradation of the former, which releases its cobalt atom as the free ion. Cobalamins are more stable in the presence of ascorbic acid but unstable to light

Uses

One of the biologically active forms of vitamin B12; differing only by the substitution of a methyl for the cyano group. Coenzyme required in the biosynthesis of methionine. Vitamin (hematopoietic).

Uses

?Histamine receptor, Alzheimer research

Definition

A vitamin B 12 analog used as an intermediate in the synthesis of methane. It is responsible for the methylation of inorganic mercury by anaerobic bacteria in bottom sediments. Through the action of methylcobalamin in an anaerobic bacteria in bottom sediments of aquatic systems, arsenic(III) is methylated to methanearsonic acid then to cacodylic acid.

Mecobalamin Preparation Products And Raw materials

Raw materials

Preparation Products


Mecobalamin Suppliers

Global( 355)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Xi'an MC Biotech, Co., Ltd.
18991951683 02989275612
8618991951683 mcbio_sales@163.com CHINA 2309 58
Guangzhou Sunton Biotechnology Co., Ltd.
18501706408 18575736215
18575736215 sunton01@sunton88.com CHINA 1342 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26734 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1010 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58

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View Lastest Price from Mecobalamin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 Mecobalamin
13422-55-4
US $25.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-10-20 Mecobalamin
13422-55-4
US $25.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd
2021-10-20 Mecobalamin
13422-55-4
US $5.00 / KG 1KG 99% 20 Tons/Months Wuhan wingroup Pharmaceutical Co., Ltd

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