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Pharmacological action Uses
Chemical Name:
MeCbl;mbl-a;Algobaz;methycobal;methyl-b12;Methylcobaz;Vitamin B12;MECOBALAMIN;MECOBALAMINE;Hitocobamin-M
Molecular Formula:
Formula Weight:
MOL File:

Mecobalamin Properties

Melting point:
>190°C (dec.)
storage temp. 
pK1:7.64(+1) (25°C)
Water Solubility 
Partially soluble in cold water, hot water.
CAS DataBase Reference


Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  2
RTECS  GG3745000
HS Code  29362600

Mecobalamin price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1424550 Methylcobalamin United States Pharmacopeia (USP) Reference Standard 13422-55-4 2x150mg $357.7 2018-11-20 Buy
Sigma-Aldrich M9756 Methylcobalamin vitamin B 13422-55-4 1g $597 2018-11-20 Buy
Alfa Aesar A11176 Methylcobalamin hydrate, 98+% 13422-55-4 500mg $288 2018-11-15 Buy
Alfa Aesar A11176 Methylcobalamin hydrate, 98+% 13422-55-4 100mg $73.4 2018-11-15 Buy
Sigma-Aldrich M9756 Methylcobalamin vitamin B 13422-55-4 25mg $73.6 2018-11-20 Buy

Mecobalamin Chemical Properties,Uses,Production

Pharmacological action

Mecobalamin as vitamin B12 derivatives, should be called "methyl vitamin B12" according to the chemical structure of name, the functional groups of methylation can be involved in the biochemical process of methyl transfer activity, promoting to nucleic acid of nerve tissue, the metabolism of protein and fat, , can stimulate the synthesis of lecithin Schwann cells, repairing the damaged myelin, improving nerve conduction velocity; directly into nerve cells, and stimulating axon regeneration of damaged area; stimulating protein synthesis in nerve cells and enhanced synthetic metabolism of axons to prevent axonal degeneration; involved in nucleic acid synthesis, promoted hematopoietic function. The treatment is clinically used in diabetic neuropathy, long-term use of macrovascular complications of diabetes are the curative effect.
Mecobalamin is used for peripheral nerve disorders treatment drug, compared with other vitamin B12 preparations, having good transfer on the nervous tissue, through the methyl transfer reaction, can promote nucleic acid, protein lipid metabolism, repairing the damaged nerve tissue. In homocysteine synthetic egg ammonia acid process, it plays a role of coenzyme, especially by deoxyuridine synthesis of thymidine, promoting DNA and RNA synthesis of participation. Also in the experiment of glial cells, the drugs can improve methionine synthase activity and promote the synthesis of myelin lipids lecithin. Improving the nerve tissue metabolism, can promot axis cable and protein synthesis, make the delivery rate of the skeletal protein close to normal, maintain axonal functions. Besides mecobalamin injections can inhibit nerve tissue of abnormal impulse conduction, promoting redl blood cells mature, split, improving anemia. Mecobalamin can be quickly restored due to lack of B12 and reduce the number of rat erythrocytes, hemoglobin, hematocrit value. Used for megaloblastic red blood cell anemia and peripheral nerve disorder due to the lack of vitamin B12.
The above information is edited by the Chemicalbook Hanya.


1.It is used for the treatment of nervous system diseases, relieving pain and numbness, speeded relieving pain, improving pain caused by cervical spondylosis, treatment of sudden deafness, etc.
2.Methylcobalamin is a kind of endogenous coenzyme B12, participating in the one carbon unit cycle, playing an important role in the synthesis of methionine homocysteine methyl transfer reaction process.

Chemical Properties

Dark Red Crystalline Powder


One of the biologically active forms of vitamin B12; differing only by the substitution of a methyl for the cyano group. Coenzyme required in the biosynthesis of methionine. Vitamin (hematopoietic).


?Histamine receptor, Alzheimer research


A vitamin B 12 analog used as an intermediate in the synthesis of methane. It is responsible for the methylation of inorganic mercury by anaerobic bacteria in bottom sediments. Through the action of methylcobalamin in an anaerobic bacteria in bottom sediments of aquatic systems, arsenic(III) is methylated to methanearsonic acid then to cacodylic acid.

Mecobalamin Preparation Products And Raw materials

Raw materials

Preparation Products

Mecobalamin Suppliers

Global( 242)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20786 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32651 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 CHINA 2097 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070; CHINA 3015 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 CHINA 894 55
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 CHINA 14293 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1659 55
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 4529 58

View Lastest Price from Mecobalamin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-01-21 vitamin b12
US $10.00 / Kg 1Kg 98.5-101.5% 10000/week hebei chisure biotechnology co.,ltd
2018-12-17 Mecobalamin
US $1.00 / kg 1kg 99% 100KG career henan chemical co

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