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Pyrroloquinoline quinone

Pyrroloquinoline quinone
Pyrroloquinoline quinone structure
CAS No.
72909-34-3
Chemical Name:
Pyrroloquinoline quinone
Synonyms
PPQ;PQQ;METHOXATIN;Methoxatine;Coenzyme PQQ;Coenzime PQQ;PQQ COFACTOR;PYRROLOQUINOLINE;PYRROLOQUINOLINE QUINONE;Pyrroloquinoline quinone ,98%
CBNumber:
CB6140290
Molecular Formula:
C14H6N2O8
Formula Weight:
330.21
MOL File:
72909-34-3.mol

Pyrroloquinoline quinone Properties

Boiling point:
1018.6±65.0 °C(Predicted)
Density 
1.963±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
1.88±0.20(Predicted)
BRN 
3596812
Stability:
Light and Temperature Sensitive
InChIKey
MMXZSJMASHPLLR-UHFFFAOYSA-N
SAFETY
  • Risk and Safety Statements
Safety Statements  22-24/25
WGK Germany  3
8
HS Code  29339900

Pyrroloquinoline quinone price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D7783 Pyrroloquinoline quinone ≥95.0% (HPLC) 72909-34-3 1mg $127 2020-08-18 Buy
Sigma-Aldrich D7783 Pyrroloquinoline quinone ≥95.0% (HPLC) 72909-34-3 5mg $361 2020-08-18 Buy
Cayman Chemical 20681 Pyrroloquinoline quinone ≥95% 72909-34-3 5mg $261 2020-06-24 Buy
Cayman Chemical 20681 Pyrroloquinoline quinone ≥95% 72909-34-3 1mg $55 2020-06-24 Buy
Sigma-Aldrich 64682 Pyrroloquinoline quinone ≥97.0% (HPLC) 72909-34-3 0 $0 2019-12-02 Buy

Pyrroloquinoline quinone Chemical Properties,Uses,Production

Description

Pyrroloquinoline quinone (PQQ) is a novel biofactor for which a proposition can be made for physiological importance. PQQ was first recognized as an enzyme cofactor in bacteria. It has recently been tentatively identified as a component of interstellar dust. Thus, PQQ may have been present throughout early biological conception and evolution. PQQ is also a potent plant growth factor. Consequently, for animals and humans, there has been constant exposure to PQQ. In animals, PQQ is reported to participate in a range of biological functions with apparent survival benefits (e.g., improved neonatal growth and reproductive performance). There are also benefits from PQQ supplementation related to cognitive, immune, and antioxidant functions, as well as protection from cardiac and neurological ischemic events. Although PQQ is not currently viewed as a vitamin, its involvement in cell signaling pathways, particularly those important to mitochondriogenesis in experimental animal models, may eventually provide a rationale for defining PQQ as vital to life. For humans, such evidence suggests there may be similar parallels or benefits from improving PQQ status.

Chemical Properties

Orange-Red Solid

Uses

A cofactor of microbial quinoprotein enzyme, and imidazopyrroline. A redox/cofactor found in a a class of enzymes called quinoproteins

Uses

PQQ has been reported to function as a water soluble vitamin/cofactor and as an antioxidant. Pyrroloquinoline quinone (PQQ) disodium salt is proposed for use due to its nutritive value in the United States (U.S.) in foods, such as energy, sport, and isotonic drinks; non-milk based meal replacement beverages; water (bottled, enhanced, fortified); milk-based meal replacement beverages; cereal and granola bars; and energy, meal replacement, and fortified bars. PQQ is also intended for use in dietary supplements.

Purification Methods

Efflorescent yellow-orange needles of PQQ are formed on recrystallising from H2O by addition of Me2CO, or better from a supersaturated aqueous solution, as it forms an acetone adduct. [Forrest et al. Nature 280 843 1979.] It has also been purified by passage through a C-18 reverse phase silica cartridge or a silanized silica gel column in aqueous solution whereby methoxantin remains behind as a red-orange band at the origin. This band is collected and washed thoroughly with dilute aqueous HCl (pH 2) and is then eluted with MeOH/H2O (7:3) and evaporated in vacuo to give the coenzyme as a red solid. It has also been purified by dissolving it in aqueous 0.5M K2CO3 and acidified to pH 2.5 whereby PQQ precipitates as a deep red solid which is collected and dried in vacuo. Methoxantin elutes at 3.55 retention volumes from a C18 _Bondapak column using H2O/MeOH (95:5) + 0.1% AcOH pH 4.5. It has UV max at 247 and 330nm (shoulder at 270nm) in H2O and max at 250 and 340nm in H2O at pH 2.5. With excitation at ex 365nm it has a max emission at 483nm. The 13C NMR has : 113.86, 122.76, 125.97, 127.71, 130.68, 137.60, 144.63, 146.41, 147.62, 161.25, 165.48, 166.45, 173.30 and 180.00ppm. When a solution in 10% aqueous MeCO is adjusted to pH 9 with aqueous NH3 and kept at 25o for 30minutes, the acetone adduct is formed; UV has max at 250, 317 and 360nm (H2O, pH 5.5), and with ex at 360nm it has max fluorescence at max at 465nm; and the 13C NMR [(CD3)2SO, TMS] has : 29.77, 51.06, 74.82, 111.96, 120.75, 121.13, 125.59, 126.88, 135.21, 139.19, 144.92, 161.01, 161.47, 165.17, 168.61, 190.16 and 207.03ppm. It also forms a methanol adduct. When it is reacted with Me2SO4/K2CO3 in dry Me2NCHO at 80o for 4hours, it forms the trimethyl ester which has m 265-267o(dec) [260-263o(dec) also reported] after recrystallisation from hot MeCN (orange crystals) with UV max at 252 and 344nm (H2O) and 251, 321 and 373nm (in MeOH; MeOH adduct ). [Duine et al. Eur J Biochem 108 187 1980, Duine et al. Adv Enzymology 59 169 1987, Corey & Tramontano J Am Chem Soc 103 5599 1981, Gainor & Weinreb J Org Chem 46 4319 1981, Hendrickson & de Vries J Org Chem 17 1148 1982, McKenzie et al. J Chem Soc, Chem Commun 1372 1983.]

Pyrroloquinoline quinone Preparation Products And Raw materials

Raw materials

Preparation Products


Pyrroloquinoline quinone Suppliers

Global( 173)Suppliers
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Henan DaKen Chemical CO.,LTD.
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View Lastest Price from Pyrroloquinoline quinone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-15 Pyrroloquinoline quinone fiona
72909-34-3
US $20.00 / KG 1KG 99% 10tons Xingtai Haoxun Import and Export Trade Co., Ltd.
2020-10-10 Pyrroloquinoline quinone
72909-34-3
US $35.00 / g 1g 99% 100KG Hebei Bonster Technology Co.,Limited
2020-06-05 Pyrroloquinoline quinone fiona
72909-34-3
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.

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