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Econazole nitrate

Pharmacological action Pharmacokinetics Usage Synthetic routes Contraindication Adverse reaction Precautions
Econazole nitrate
Econazole nitrate
Chemical Name:
Econazole nitrate
ifenec;r14,827;pevaryl;palavale;ecostatin;Spectazole;epi-pevaryl;gyno-pevaryl;ECONAZOL NITRATE;Econazole nitrate
Molecular Formula:
Formula Weight:
MOL File:

Econazole nitrate Properties

1.6311 (rough estimate)
refractive index 
1.6200 (estimate)
CAS DataBase Reference
68797-31-9(CAS DataBase Reference)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  22-36/38
Safety Statements  26-36
WGK Germany  3
RTECS  NI4450000
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:

Econazole nitrate price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1231808 Econazole nitrate 68797-31-9 1EA $338.1 2017-11-08 Buy
Sigma-Aldrich 1231808 Econazole nitrate 68797-31-9 100mg $347.4 2017-11-08 Buy
Sigma-Aldrich E0050000 Econazole nitrate 68797-31-9 1EA $168 2017-11-08 Buy
Sigma-Aldrich Y0000254 Econazole for system suitability 68797-31-9 1EA $168 2017-11-08 Buy

Econazole nitrate Chemical Properties,Uses,Production

Pharmacological action

Econazole nitrate, as a dechlorination derivative of miconazole, is an antifungal drug of piromidic. It has the antibacterial activity against candida, fonsecaea, coccidioides, histoplasma, sporotrichum and so on, and also has the anti-microbial activity against trichophyton,etc, but poor properties on aspergillus, sporothrix schenckii, some dermateaceae and mucor. It can disrupt the activity of cytochrome P450 to inhibit the biosynthesis of ergosterol, the main steroids of fungal cell membrane, damage the fungal cell membrane and change its permeability, so that the important intracellular matter leak out. It can inhibit the biosynthesis of triacylglycerol and phospholipid and the activity of oxidase and peroxidase to cause the accumulation of hydrogen peroxide in cells, which results in submicrostructure degeneration and necrocytosis. It can inhibit the transformation of candida albicans from spores to invasive hypha. It is applicable to tinea manuum, tinea pedis, tinea cruris, tinea corporis, tinea versicolor and cutaneous candidiasis.


After external use, most medicines enter into the epidermis, as well as the dermis. Only 1% can be absorbed into the blood stream. The amount of reabsorption in urine and faeces is less than 1% of the dosage.


It is applicable to tinea corporis, tinea manuum, tinea pedis, tinea cruris, tinea corporis, tinea versicolor and cutaneous candidiasis.

Synthetic routes

Use trichloroacetophenon as the starting material. After revivification and imidazole, add p-chlorobenzyl chloride to prepare the econazole through substitution. Finally econazole nitrate is obtained by salifying with nitric acid.
synthetic route of econazole nitrate
Fig. 1 shows the synthetic route of econazole nitrate


Adverse reaction



Econazole nitrate (EN) is a broad-spectrum antifungal medication used topically in the treatment of dermatomycoses due to a wide variety of fungi, such as athlete’s foot, jock itch, ringworm, and pityriasis. It is also used vaginally in the treatment of vaginal candidosis.


[1] P. Verma, B. Pharm, M. Pharm, K. Pathak, M. Pahrm, Nanosized ethanolic vesicles loaded with econazole nitrate for the treatment of deep fungal infections through topical gel formulation, Nanomedicine: Nanotechnology, Biology, and Medicine, 2012, vol. 8, 489-496
[2] R. C. Heel, R. N. Brogden, T. M. Speight and G. S. Avery, Econazole: A Review of its Antifungal Activity and Therapeutic Efficacy, Drugs, 1978, vol. 16, 177-201

Econazole nitrate Preparation Products And Raw materials

Raw materials

Preparation Products

Econazole nitrate Suppliers

Global( 102)Suppliers
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