1H-Benz[de]isoquinoline-2(3H)-butanamide
- CAS No.
- 300816-11-9
- Chemical Name:
- 1H-Benz[de]isoquinoline-2(3H)-butanamide
- Synonyms
- script;1H-Benz[de]isoquinoline-2(3H)-butanamide, N-hydroxy-1,3-dioxo-;1H-Benz[de]isoquinoline-2(3H)-butanamide, N-hydroxy-1,3-dioxo- (9CI)
- CBNumber:
- CB6503992
- Molecular Formula:
- C16H14N2O4
- Molecular Weight:
- 298.29
- MDL Number:
- MFCD00405081
- MOL File:
- 300816-11-9.mol
SAFETY
Risk and Safety Statements
Safety Statements | 22-24/25 |
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1H-Benz[de]isoquinoline-2(3H)-butanamide price More Price(10)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Alfa Aesar | J67363 | Nullscript, 97% | 300816-11-9 | 1mg | $104 | 2021-12-16 | Buy |
Cayman Chemical | 16433 | Nullscript ≥98% | 300816-11-9 | 1mg | $68 | 2024-03-01 | Buy |
Cayman Chemical | 16433 | Nullscript ≥98% | 300816-11-9 | 5mg | $302 | 2024-03-01 | Buy |
Cayman Chemical | 16433 | Nullscript ≥98% | 300816-11-9 | 10mg | $535 | 2024-03-01 | Buy |
ApexBio Technology | C3606 | Nullscript | 300816-11-9 | 10mg | $610 | 2021-12-16 | Buy |
1H-Benz[de]isoquinoline-2(3H)-butanamide Chemical Properties,Uses,Production
Definition
ChEBI: 4-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-hydroxybutanamide is a member of isoquinolines.
Biological Activity
nullscript is an hdac inhibitor.histone deacetylase inhibitors (hdis) have been used in psychiatry and neurology as mood stabilizers and anti-epileptics, such as valproic acid. recently, hdis are being studied as a mitigator or treatment for neurodegenerative diseases. moreover, there has been an effort to develop hdis for cancer therapy.
in vitro
nullscript, a close analog of scriptaid, was found to be inactive in transcriptional facilitation at corresponding concentrations, which confirmed a minimal requirement for the length of the linker chain expected for this class of hdac inhibitors. in addition, nullscript was not able to induce the p6sbe-luc reporter construct, which was identified from the library using chemfinder by its structural similarity to scriptaid [1].
in vivo
a standard in vivo model of cardiac i/rwe was utilized to examine the in vivo consequences of hdac inhibition in the intact heart. results showed that the treatment with scriptaid led to a nearly identical effect when compared to nullscript, with a 46.8% reduction in infarct size. such results strongly suggested that in murine models, hdacis could reverse the induction of ischemia-induced hdac activity and reduced myocardial infarct size by more than 50% [2].
References
[1] g. h. su, t. a. sohn, b. ryu, et al. a novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. cancer research 60, 3137-3142 (2000).
[2] anne granger et al. histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. faseb j. 2008 oct; 22(10): 3549–3560.
1H-Benz[de]isoquinoline-2(3H)-butanamide Preparation Products And Raw materials
Raw materials
Preparation Products
1H-Benz[de]isoquinoline-2(3H)-butanamide Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Duling International Trade Co. LTD | +8617333973358 | sales01@hbduling.cn | China | 15510 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
Shaanxi Didu New Material Co., Ltd | 029-63373950 15353716720 | 1052@dideu.com | China | 10010 | 58 |
ApexBio Technology | -- | sales@apexbt.com | United States | 6254 | 58 |