ChemicalBook
Chinese Japanese Germany

Olanzapine

Antipsychotics Chemical properties Uses Production method
Olanzapine
Olanzapine
CAS No.
132539-06-1
Chemical Name:
Olanzapine
Synonyms
Oliza;Oltal;Larmac;Oleanz;lanzac;ZYPREXA;Integrol;LY-170053;OLANZAPINE;Olanzapine, >=99%
CBNumber:
CB6755515
Molecular Formula:
C17H20N4S
Formula Weight:
312.43
MOL File:
132539-06-1.mol

Olanzapine Properties

Melting point:
195°C
Flash point:
2℃
storage temp. 
-20°C Freezer
solubility 
DMSO: >15mg/mL
form 
powder
color 
yellow
Merck 
14,6822
BRN 
7655141
CAS DataBase Reference
132539-06-1(CAS DataBase Reference)
NIST Chemistry Reference
Olanzapine(132539-06-1)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,Xn,F
Risk Statements  36/38-36-20/21/22-11
Safety Statements  26-36/37-16
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
RTECS  XJ9007750
HazardClass  6.1
PackingGroup  III
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H413 May cause long lasting harmful effects to aquatic life Hazardous to the aquatic environment, long-term hazard Category 4
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P235 Store in a well-ventilated place. Keep cool.

Olanzapine price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich O-024 Olanzapine solution 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material 132539-06-1 024-1ml $69 2018-11-13 Buy
Sigma-Aldrich 1478301 Olanzapine United States Pharmacopeia (USP) Reference Standard 132539-06-1 200mg $352.8 2018-11-13 Buy
TCI Chemical O0393 Olanzapine >98.0%(GC)(T) 132539-06-1 1g $68 2018-11-22 Buy
TCI Chemical O0393 Olanzapine >98.0%(GC)(T) 132539-06-1 5g $234 2018-11-22 Buy
Cayman Chemical 11937 Olanzapine ≥98% 132539-06-1 25mg $25 2018-11-13 Buy

Olanzapine Chemical Properties,Uses,Production

Antipsychotics

Olanzapine also known as olanzapine, olanzapine Oran, is a common antipsychotic drugs, clinically used to control schizophrenia, bipolar mania and agitation symptoms of dementia, it can significantly improve schizophrenia negative (for example: apathy, emotional and social withdrawal, poverty of speech), positive symptoms (such as: delusions, hallucinations, thought disorder, hostility and suspicion), and it may also relieve common secondary schizophrenia and related disorders affective symptoms.
Good oral absorption, it needs 5-8 hours to reach the peak plasma concentration, and it is not affected by eating, it is metabolized in the liver through a combination of oxidation ; the major circulating metabolite is the 10-N-glucuronide.
Animal experiments show that olanzapine displays affinity on multiple receptors 5-HT, dopamine D, α-adrenergic, histamine H et , the affinity with 5-HT2 receptor in vitro and in vivo is greater than its affinity for dopamine D2 receptors.
Animal behavior studies show that olanzapine has a 5-HT, dopamine, and cholinergic antagonism effect, and it is consistent with its receptor binding situation.
Electrophysiological studies show that olanzapine selectively reduces the limbic system (A10) dopaminergic neurons discharge, while the effect on the striatal (A9) motor path function is very small. In the reaction below to produce froze dosage levels, it can reduce the conditioned avoidance response. Different with other antipsychotics, olanzapine increases the anxiolytic response in test .
The above information is edited by the chemicalbook of Tian Ye.

Chemical properties

Crystallization from acetonitrile, melting point of 195 ℃.

Uses

Used to control schizophrenia, bipolar mania and other diseases

Production method

4-amino-2-methyl-10H-thieno [2,3-b] [1,5] benzo-diazepin-hydrochloride and N-methylpiperazine in toluene and dimethylsulfoxide , reflux under nitrogen for 20h, to obtain olanzapine.

Chemical Properties

Yellow Crystalline Powder

Uses

A serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic.

Uses

intermediate for Imidacloprid, Indobufen, Nitroguanidine, Nalorphine, Tazarotene, Trovafloxacin

Uses

anti-ulcer, gastrointestinal-emptying agent enhances motility in the upper gastrointestinal tract

Definition

ChEBI: A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.

brand name

Zyprexa (Lilly).

Olanzapine Preparation Products And Raw materials

Raw materials

Preparation Products


Olanzapine Suppliers

Global( 292)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22058 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32763 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20000 58
Lianyungang happen teng technology co., LTD
15950718863
wang666xt@163.com CHINA 305 58
Wuhan Wsem Biological Co., Ltd. 027-59402396 ; 13419635609(WX)
027-59402396 13419635609@163.com China 4596 55
Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
+86-21-57758967 sales@boylechem.com China 2220 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Taizhou Huading Chemical Co., Ltd 0576-88583898
0576-88587373 Sales@huatopchem.com China 61 55

View Lastest Price from Olanzapine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Olanzapine
132539-06-1
US $1.00 / KG 1G 98% 100KG career henan chemical co

132539-06-1(Olanzapine)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved