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Lornoxicam

Description References
Lornoxicam
Lornoxicam structure
CAS No.
70374-39-9
Chemical Name:
Lornoxicam
Synonyms
Xefo;Telos;TS 110;Xefocam;Ro 13-9297;LORNOXICAM;AKOS 93662;Lornoxicam>chlortenoxicam;LornoxicaM API
CBNumber:
CB7224647
Molecular Formula:
C13H10ClN3O4S2
Formula Weight:
371.82
MOL File:
70374-39-9.mol

Lornoxicam Properties

Melting point:
225-230°C (dec.)
Density 
1.742±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO: >5mg/mL (warmed)
pka
pKa2 4.7(at 25℃)
form 
powder
color 
faint yellow to dark yellow
Merck 
14,5582
InChIKey
WLHQHAUOOXYABV-UHFFFAOYSA-N
CAS DataBase Reference
70374-39-9(CAS DataBase Reference)
FDA UNII
ER09126G7A
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H300
Precautionary statements  P264-P301+P310-P270-P301+P310+P330-P405-P501
Hazard Codes  Xi,T+
Risk Statements  36/37/38-28
Safety Statements  26-36-45-36/37-28
RIDADR  UN 2811 6.1 / PGII
WGK Germany  3
RTECS  XJ9095000
HazardClass  IRRITANT
PackingGroup  II
HS Code  29349990
Toxicity LD50 orally in mice, rats, rabbits, dogs, monkeys: >10 mg/kg (Pruss)

Lornoxicam price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0338 Lornoxicam ≥98% (HPLC) 70374-39-9 10mg $78.1 2020-08-18 Buy
Sigma-Aldrich SML0338 Lornoxicam ≥98% (HPLC) 70374-39-9 50mg $317 2020-08-18 Buy
TCI Chemical L0239 Lornoxicam >98.0%(HPLC)(N) 70374-39-9 1g $164 2020-06-24 Buy
TCI Chemical L0239 Lornoxicam >98.0%(HPLC)(N) 70374-39-9 5g $500 2020-06-24 Buy
Cayman Chemical 70220 Lornoxicam ≥98% 70374-39-9 50mg $45 2020-06-24 Buy

Lornoxicam Chemical Properties,Uses,Production

Description

Lornoxicam (Trade name: “Xefo”) belongs to a non-steroidal anti-inflammatory drug. As a kind of oxicam class drug, it has analgesic, anti-inflammatory and antipyretic properties. It can be used for the treatment of various type of acute mild to moderate pain which results from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and rheumatic diseases. Lornoxicam is capable of potently inhibiting the prostaglandin biosynthesis process, making it have highly pronounced efficacy. The exact mechanism of Lornoxicam is not exactly understood. However, it is indicated that Lornoxicam can inhibit the prostaglandin and thromboxane synthesis by inhibiting both COX-1 and COX-2, leading to reduction of inflammation, pain, fever, and swelling.

References

https://www.drugbank.ca/drugs/DB06725
https://en.wikipedia.org/wiki/Lornoxicam

Description

Xefo, a member of the oxicam family of nonsteroidal antiinflammatory agents, was launched in Denmark for mild to moderate pain and inflammation. A seven step synthesis, beginning with 2,5-dichlorothiophene, provides access to this compound. It inhibits prostaglandin synthesis at the level of cyclooxygenase (Cox1 :Cox2 = 0.6) but does not inhibit 5-lipoxygenase. Xefo did not increase serum levels of pepsinogen I (an indicator of gastric mucosal status) and readily penetrates perivascular interstitial spaces including synovial fluid. It is as effective as morphine, meperidine and tramadol in relieving post operative pain and as efficient as other NSAlDs in relieving the symptoms of osteoarthritis and rheumatoid arthritis. It is 100 times more potent than Tenoxicam in inhibiting PGD2 and more active than indomethacin (6x) or piroxicam (10x) in preventing arachadonic acid influenced lethality in mice. Xefo has inhibitor effects on spinal nocicceptive processing presumably via release of endogenous opiods and evidence suggests it is good for migraine.

Chemical Properties

Crystalline Solid

Originator

Nycomed Amersham (Norway)

Uses

Cyclooxygenase inhibitor; structurally similar to tenoxicam. Anti-inflammatory; analgesic

Uses

keratolytic, antiacne, antineoplastic

Uses

ocular vasoconstrictor

Uses

For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases.

Definition

ChEBI: A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 6-chloro-4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for th treatment of pain, primarily resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and other inflammations.

brand name

Xefo

Lornoxicam Preparation Products And Raw materials

Raw materials

Preparation Products


Lornoxicam Suppliers

Global( 276)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30039 58
Casorganics US Corp
+17326109938
sales@casorganics.com CHINA 175 58
BOC Sciences
1-631-619-7922 1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20039 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 420 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35434 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47486 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072
+8613111626072 zzwenxi@126.com CHINA 7507 58
Antai Fine Chemical Technology Co.,Limited
+86-18503026267
info@antaichem.com CHINA 9664 58

View Lastest Price from Lornoxicam manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-04-29 Lornoxicam
70374-39-9
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2020-05-07 Lornoxicam
70374-39-9
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2018-08-20 Lornoxicam
70374-39-9
US $1.00 / KG 1G 98% 100KG career henan chemical co

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