DIMETHYLPHOSPHINE OXIDE
- CAS No.
- 7211-39-4
- Chemical Name:
- DIMETHYLPHOSPHINE OXIDE
- Synonyms
- methylphosphonoylmethane;Methylphosphinoylmethane;Einecs 230-591-2;Dimethylphosphinoxid;Dimethyl-Oxophosphonium;DIMETHYLPHOSPHINE OXIDE;imethyl(oxo)phosphanium;dimethyl(oxo)phosphanium;DIMETHYLPHOSPHINOUS ACID;Keto-Dimethyl-Phosphonium
- CBNumber:
- CB7447743
- Molecular Formula:
- C2H7OP
- Molecular Weight:
- 78.05
- MDL Number:
- MFCD02824571
- MOL File:
- 7211-39-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319-H335-H315 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501 |
DIMETHYLPHOSPHINE OXIDE price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Strem Chemicals | 15-1425 | Dimethylphosphine oxide, min. 95% | 7211-39-4 | 500mg | $94 | 2024-03-01 | Buy |
| Strem Chemicals | 15-1425 | Dimethylphosphine oxide, min. 95% | 7211-39-4 | 2g | $278 | 2024-03-01 | Buy |
| Biosynth Carbosynth | FD166291 | Dimethylphosphine oxide | 7211-39-4 | 10g | $300 | 2021-12-16 | Buy |
| SynQuest Laboratories | 6174-1-01 | Dimethylphosphine oxide | 7211-39-4 | 5G | $450 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0315044 | DIMETHYLPHOSPHINE OXIDE 95.00% | 7211-39-4 | 5MG | $497.68 | 2021-12-16 | Buy |
DIMETHYLPHOSPHINE OXIDE Chemical Properties,Uses,Production
Description
Dimethylphosphine oxide is an organophosphorus compound. It can be used for the preparation of triacrylphosphine oxide. It can be used as an asymmetric catalyst. In addition, it can be used for the preparation of alkenyldiphenylphosphine oxides, and Horner-Witting reagents. In addition, it is also a kind of capping ligand in organic chemistry.
Chemical Properties
Dimethylphosphine oxide is a colorless liquid that soluble in polar organic solvents.It exists as the phosphine oxide, not the hydroxy tautomer.
Uses
Dimethylphosphine Oxide is used in preparation of substituted piperazine derivatives as DGKα/DGKζ inhibitors for the treatment of viral infections and cancer. It is also used as an organic synthetic raw material for the preparation of (α-aminoalkyl)dimethylphosphine oxide enantiomers. Asymmetric synthesis of α-amino-α-polyfluoroalkyl dimethylphosphine oxides was accomplished through diastereoselective addition of dimethylphosphine oxide to enantiomeric Ellman's aldimines, RFCH=NS(O)tert-Bu (RF=CF3, CHF2, PhCF2).
Application
Dimethylphosphine oxide (DMPO) is a hydrogen bonding receptor that can be used to prepare ALK inhibitor compounds (WX-0593) containing DMPO molecules. The results of enzyme assay experiments showed that WX-0593 has high activity against wild-type and mutant ALK, and also inhibits ROS1WT in Ba/F3 cell line very well. In addition, WX-0593 is currently undergoing a phase I/II trial in ALK-positive NSCLC and is expected to be used for the treatment of ROS1-positive NSCLC.
Reactions
Chlorination gives dimethylphosphoryl chloride. It undergoes hydroxymethylation with formaldehyde. Me2P(O)H+CH2O→Me2P(O)CH2OH Many aldehydes effect a similar reaction.
References
https://en.wikipedia.org/wiki/Dimethylphosphine_oxide
http://www.sigmaaldrich.com/catalog/product/aldrich/287881?lang=en®ion=US
Ganesan, Paramasivam, and S. Lakshmipathi. "Impact of heterogeneous passivation of trimethylphosphine oxide and di-methylphosphine oxide surface ligands on the electronic structure of Cd n Se n, (n =6, 15) quantum dots: A DFT study." Physica E: Low-dimensional Systems and Nanostructures 83(2016):284-296.
DIMETHYLPHOSPHINE OXIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2255 | 58 |
| Shanghai Famo Biotech Co Ltd | +86-36680037 +86-18550473860 | mayan@famobiotech.com;sales@famobiotech.com | China | 528 | 58 |
| Puyang Huicheng Electronic Materials Co., Ltd. | +86-0393-+86-0393-8910800 +8615839383373 | info@huichengchem.com | China | 524 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20293 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
| Zhengzhou Yuanli Biological Technology Co., Ltd | 0086-371-67897895 | info@zzyuanli.cn | CHINA | 136 | 58 |
View Lastest Price from DIMETHYLPHOSPHINE OXIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-15 | DIMETHYLPHOSPHINE OXIDE
7211-39-4
|
US $20.00-1.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2024-05-28 | Dimethylphosphinoxid
7211-39-4
|
US $0.00-0.00 / kg | 1kg | 95% | 20tons | Puyang Huicheng Electronic Materials Co., Ltd. | |
 |
2024-04-09 | DIMETHYLPHOSPHINE OXIDE
7211-39-4
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
-
- DIMETHYLPHOSPHINE OXIDE
7211-39-4
- US $20.00-1.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Dimethylphosphinoxid
7211-39-4
- US $0.00-0.00 / kg
- 95%
- Puyang Huicheng Electronic Materials Co., Ltd.
-
- DIMETHYLPHOSPHINE OXIDE
7211-39-4
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
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