Glabridin

Glabridin Properties

Melting point	154～155℃
Boiling point	518.6±50.0 °C(Predicted)
Density	1.257±0.06 g/cm3(Predicted)
Flash point	267℃
storage temp.	room temp
solubility	DMSO: soluble5mg/mL, clear (warmed)
form	powder
pka	9.66±0.40(Predicted)
color	white to light brown
BRN	7141956
Stability	Hygroscopic
InChI	InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
InChIKey	PMPYOYXFIHXBJI-ZDUSSCGKSA-N
SMILES	C1(O)=CC=C([C@@H]2COC3=C4C=CC(C)(C)OC4=CC=C3C2)C(O)=C1
LogP	4.260 (est)
CAS DataBase Reference	59870-68-7(CAS DataBase Reference)
FDA UNII	HOC5567T41

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332

Precautionary statements

P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312

Safety Statements

24/25

WGK Germany

3

HS Code

29329990

NFPA 704

	0
3		0

Glabridin price More Price(42)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	G9548	Glabridin ≥98% (HPLC), powder	59870-68-7	5mg	$129	2024-03-01	Buy
Sigma-Aldrich	PHL80463	Glabridin phyproof? Reference Substance	59870-68-7	10MG	$584	2024-03-01	Buy
Sigma-Aldrich	53633	Glabridin analytical standard	59870-68-7	10mg	$826	2022-05-15	Buy
Cayman Chemical	11843	Glabridin ≥98%	59870-68-7	5mg	$68	2024-03-01	Buy
Cayman Chemical	11843	Glabridin ≥98%	59870-68-7	10mg	$89	2024-03-01	Buy

Product number	Packaging	Price	Buy
G9548	5mg	$129	Buy
PHL80463	10MG	$584	Buy
53633	10mg	$826	Buy
11843	5mg	$68	Buy
11843	10mg	$89	Buy

Glabridin Chemical Properties,Uses,Production

Chemical Properties

White to tan powder, insoluble in water, easily soluble in organic solvents such as ethanol, propylene glycol, 1,3-butanediol, etc.

Uses

Glabridin is a compound extracted from Licorice (root) shows properties that are cytotoxic, antimicrobial, estrogenic and anti-proliferative.

Definition

ChEBI: Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. It has a role as an antiplasmodial drug. It derives from a hydride of a (R)-isoflavan.

benefits

Glabridin has strong antibacterial effects and can prevent inflammation, pigmentation, and rough skin caused by ultraviolet rays. It can also remove superoxide ions and inhibit hemolysis caused by hydrogen peroxide. Moreover, it can inhibit the activity of tyrosinase and the conversion of dopachrome, making it an effective and environmentally-friendly additive for whitening and freckle removal in cosmetics. Additionally, Glabridin possesses similar abilities to scavenge oxygen free radicals as SOD (superoxide dismutase) and vitamin E, making it a powerful antioxidant.

Biochem/physiol Actions

Glabridin is a bio-available isoflavan isolated from licorice (Glycyrrhiza glabra L.) root extract. Glabridin has been reported to posses varies biological activities including strong antioxidant activity, antioxidant against LDL oxidation, anti-Helicobacter pylori properties, estrogen-like activity and antinephritic and radical scavenging activities. Also it appears to inhibit serotonin re-uptake, melanogenesis, inflammation and cytochrome P450 3A4, 2B6, and 2C9.

Mode of action

Glabridin[59870-68-7] is one of the main flavonoid components in Glycyrrhiza glabra. It shows a strong anti-free radical oxidation effect in the cytochrome P450/NADPH oxidation system, which can significantly inhibit the free radicals produced in the metabolic process of the body, to avoid oxidative damage to oxidation-sensitive biological macromolecules (low-density lipoprotein LDL, DNA) and the cell wall, etc. by free radical oxidation. Thus, it can prevent certain pathological changes related to free radical oxidation, such as atherosclerosis, and cellular aging. In addition, Glabridin has some hypolipidemic and hypotensive effects.

References

Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium‐induced colitis DOI:10.1111/j.1365-2249.2007.03539.x
Structural insights into the binding behavior of isoflavonoid glabridin with human serum albumin DOI:10.1016/J.FOODHYD.2019.01.031
A novel ?uorescent recombinant cell-based biosensor for screening NLRP3 inflammasome inhibitors DOI:10.1016/j.snb.2019.126864
Glavonoid, a possible supplement for prevention of ATTR amyloidosis DOI:10.1016/j.heliyon.2021.e08101
Tian, M. et al.: Int. J. Mol. Sci., 9, 571 (2008); Simmler, C. et al.: Fitoterapia, 90, 160 (2013);

Glabridin synthesis

Synthesis of Glabridin from 7-Hydroxycoumarin

Glabridin Preparation Products And Raw materials

Raw materials

7-Hydroxycoumarin

Preparation Products

Glabridin Suppliers

Global( 499)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	2995	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9427	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	+8618829768577	gao490372054@gamil.com	China	1250	58
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	lisa@yibangte.com	China	2987	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Wuhan Quanjinci New Material Co.,Ltd.	+8615271838296	kyra@quanjinci.com	China	1532	58
BINBO BIOLOGICAL CO.,LTD	+8618629063126	info@binbobiological.com	China	290	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Sinopharm International Guangzhou Ltd.	+86-2038033341 +86-18520036739	zhuluqiang@sinopharm.com	China	77	58
Henan Tengmao Chemical Technology Co. LTD	+8615238638457	salesvip2@hntmhg.com	China	415	58

Supplier	Advantage
Xi'an Kono chem co., Ltd.,	58
Baoji Guokang Healthchem co.,ltd	58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd	58
Hebei Kingfiner Technology Development Co.Ltd	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Wuhan Quanjinci New Material Co.,Ltd.	58
BINBO BIOLOGICAL CO.,LTD	58
Hebei Mojin Biotechnology Co., Ltd	58
Sinopharm International Guangzhou Ltd.	58
Henan Tengmao Chemical Technology Co. LTD	58

View Lastest Price from Glabridin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-26	Glabridin 59870-68-7	US $0.00-0.00 / kg	0.10000000149011612kg	≥90%、98%	20tons	Chongqing Zhihe Biopharmaceutical Co., Ltd.
2024-04-23	Glabridin 59870-68-7	US $100.00 / kg	1kg	99	5000	Hebei Zhuanglai Chemical Trading Co.,Ltd
2024-04-23	Glabridin 59870-68-7	US $0.00-0.00 / g	1g	98%	2000	Changsha Staherb Natural Ingredients Co., Ltd.

Glabridin
59870-68-7
US $0.00-0.00 / kg
≥90%、98%
Chongqing Zhihe Biopharmaceutical Co., Ltd.

Glabridin
59870-68-7
US $100.00 / kg
99
Hebei Zhuanglai Chemical Trading Co.,Ltd

Glabridin
59870-68-7
US $0.00-0.00 / g
98%
Changsha Staherb Natural Ingredients Co., Ltd.

Glabridin Spectrum

Glabridin(59870-68-7)¹HNMR

59870-68-7(Glabridin)Related Search:

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TATM ISOFLAVONES Zinc Glycyrrhizinate acid 30% HPLC

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1,3-Benzenediol, 4-(3,4-dihydro-8,8-diMethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-, (R)- (R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl)-1,3-benzenediol 4-[(3R)-3,4-Dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b′]dipyran-3-yl]-1,3-benzenediol Glabridin, >=98% Glabridin/Propylene Glycol 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol GLABRIDIN 4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H-pyrano[6,5-f]chromen-3-yl]benzene-1,3-diol 4-((R)-8,8-Dimethyl-3,4-dihydro-2H,8H-benzo[1,2-B:4,3-B']dipyran-3-yl)-benzene-1,3-diol Aids096010 Aids-096010 GLABRIDIN(RG) GLABRIDIN (GLYCYRRHIZA GLABRA ROOT EXTRACT) 4-(8,8-DiMethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chroMen-3-yl)-benzene-1,3-diol 2H,8H-Benzo[1,2-b:3,4-b']dipyran,1,3-benzenediolderiv Liquorice flavonoids Glabridin, froM Liquorice root Glabridin/OIL SOLUBLE LICORICE(GLYCYRRHIZA) EXTRACT professional manufacturer Glabridin 59870-68-7 98% Glabridin 59870-68-7 Light-yellow powder Light liquorice set LGB-GD 90 LGB-GD 40 Soluble GLABRIDIN, Liposomal GLABRIDIN, GLABRIDIN NanoEmulsion, NanoActive GLABRIDIN BioaActive Glabridin Nanoactive Glabridin Soluble Glabridin 1,3-Benzenediol,4-[(3R)-3,4-dihydro-8,8-dimethyl-2H,8H-benzo[1,2-b:3,4-b']dipyran-3-yl]- Glabridin, 98%, from Liquorice root KB-289522 LS-176045 Q-100692 Glabridin，96% Glabridin USP/EP/BP glabridin 90% Licorice Extract – Glabridin water soluble glabridin (R)-4-(8,8-Dimethyl-2,3,4,8-tetrahydropyrano[2,3-f]chromen-3-yl)benzene-1,3-diol Glabridin、Glycyrrhiza Glabra (Licorice) Root Extract GlabridinQ: What is Glabridin Q: What is the CAS Number of Glabridin Q: What is the storage condition of Glabridin Q: What are the applications of Glabridin Glabridin 90%(White powder) Light licorice Nano-Liposomal Glabridin, Water-Soluble Glabridin Glabridin Glycyrrhiza extract Carbazochrome Impurity 26 Guanggancao Ding glabridine 59870-68-7 5987-68-7 Miscellaneous Natural Products chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract Natural Plant Extract 59870-68-7