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4SC-202

CAS No.
1186222-89-8
Chemical Name:
4SC-202
Synonyms
CS-1272;4SC-202;4SC-202.TsOH;4SC-202 tosylate;Domatinostat tosylate;4SC-202;4SC202;4SC 202;Domatinostat tosylate,Domatinostat,Apoptosis,inhibit,Histone deacetylases,Inhibitor,HDAC;(E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide 4-methylbenzenesulfonate;4SC-202 2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)-, 4-methylbenzenesul
CBNumber:
CB82624903
Molecular Formula:
C30H29N5O6S2
Molecular Weight:
619.71116
MDL Number:
MFCD25976779
MOL File:
1186222-89-8.mol
Last updated:2024-07-02 08:55:20

4SC-202 Properties

storage temp. Store at -20°C
solubility insoluble in H2O; ≥2.4 mg/mL in EtOH with gentle warming and ultrasonic; ≥62 mg/mL in DMSO
form Powder
color Light yellow to brown
FDA UNII 9PW28FR8VD

4SC-202 price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 26175 4SC-202 1186222-89-8 25mg $558 2024-03-01 Buy
Cayman Chemical 26175 4SC-202 1186222-89-8 50mg $979 2024-03-01 Buy
Cayman Chemical 26175 4SC-202 1186222-89-8 5mg $141 2024-03-01 Buy
Cayman Chemical 26175 4SC-202 1186222-89-8 10mg $253 2024-03-01 Buy
ApexBio Technology B4106 4SC-202 1186222-89-8 50mg $450 2021-12-16 Buy
Product number Packaging Price Buy
26175 25mg $558 Buy
26175 50mg $979 Buy
26175 5mg $141 Buy
26175 10mg $253 Buy
B4106 50mg $450 Buy

4SC-202 Chemical Properties,Uses,Production

Description

4SC-202 is an inhibitor of the class I histone deacetylases (HDACs) HDAC1-3 and the histone demethylase KDM1A. It reduces cell viability in a panel of colorectal cancer (CRC) cell lines when used at concentrations ranging from 1 to 10 μM and in patient-derived CRC cell lines when used at a concentration of 5 μM. 4SC-202 (5 μM) induces cell cycle arrest at the G2/M phase in HT-29 cells and primary human CRC cells and increases apoptosis in HT-29 cells in a concentration-dependent manner, an effect that is enhanced by the Akt inhibitors perifosine and MK-2206 . 4SC-202 (100 mg/kg, p.o., every other day) reduces tumor growth in an HT-29 mouse xenograft model when administered alone and to an enhanced degree when co-administered with oxaliplatin (Item No. 13106).

in vivo

studies, 4sc-202 has shown a good tolerability and dose-dependent effect on anti-tumour activity compared with other inhibitors in the a549nsclc xenograft model and the rko27 colon carcinoma model [1].

References

[1] henning s w, doblhofer r, kohlhof h, et al. 178 preclinical characterization of 4sc-202, a novel isotype specific hdac inhibitor[j]. european journal of cancer supplements, 2010, 8(7): 61.

4SC-202 Preparation Products And Raw materials

Raw materials

Preparation Products

4SC-202 Suppliers

Global( 59)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795 ivan@atkchemical.com China 32836 60
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10522 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Coresyn Pharmatech Co., Ltd.
+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9991 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3136 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054 trendseenbio@gmail.com China 11681 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131980 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61

4SC-202 Spectrum

4SC-202 4SC-202 2-Propenamide, N-(2-aminophenyl)-3-[1-[[4-(1-methyl-1H-pyrazol-4-yl)phenyl]sulfonyl]-1H-pyrrol-3-yl]-, (2E)-, 4-methylbenzenesul (E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide 4-methylbenzenesulfonate 4SC-202 tosylate CS-1272 Domatinostat tosylate 4SC-202;4SC202;4SC 202 Domatinostat tosylate,Domatinostat,Apoptosis,inhibit,Histone deacetylases,Inhibitor,HDAC 4SC-202.TsOH 1186222-89-8 C30H29N5O6S2