Nifekalant hydrochloride
- CAS No.
- 130656-51-8
- Chemical Name:
- Nifekalant hydrochloride
- Synonyms
- ms551;Shinbit;NIFEKALANT HCL;NIFEKALANT HYDROCHLORIDE;Nifekalant 130636-43-0 /;Nifekalant hydrochloride (MS-551);Nifekalant hydrochloride USP/EP/BP;6-[2-[2-hydroxyethyl-[3-(4-nitrophenyl)propyl]amino]ethylamino]-1,3-dimethylpyrimidine-2,4-dione hydrochloride;1,3-Dimethyl-6-((2-(N-(2-hydroxyethyl)-3-(4-nitrophenyl)propylamino)ethylamino)-2,4(1H),3H)-pyrimidinedione HCl;1,3-Dimethyl-6-[2-(N-(2-hydroxyethyl)-3-(4-nitrophenyl)propylamino)ethylamino]-2,4(1H,3H)-pyrimidinedione hydrochloride
- CBNumber:
- CB8325413
- Molecular Formula:
- C19H28ClN5O5
- Molecular Weight:
- 441.91
- MDL Number:
- MFCD00892243
- MOL File:
- 130656-51-8.mol
- MSDS File:
- SDS
| Melting point | 172-174° |
|---|---|
| storage temp. | Refrigerator |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly) |
| form | Solid |
| pka | 7.05(at 25℃) |
| color | Light Yellow to Yellow |
| CAS DataBase Reference | 130656-51-8(CAS DataBase Reference) |
| FDA UNII | TPP5R0MDQS |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Nifekalant hydrochloride price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20997 | Nifekalant (hydrochloride) ≥98% | 130656-51-8 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 20997 | Nifekalant (hydrochloride) ≥98% | 130656-51-8 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 20997 | Nifekalant (hydrochloride) ≥98% | 130656-51-8 | 10mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 20997 | Nifekalant (hydrochloride) ≥98% | 130656-51-8 | 25mg | $243 | 2024-03-01 | Buy |
| TRC | N457100 | NifekalantHydrochloride | 130656-51-8 | 1g | $1165 | 2021-12-16 | Buy |
Nifekalant hydrochloride Chemical Properties,Uses,Production
Description
Nifekalant is a novel and pure class III anti-arrhythmic agent introduced in Japan as Shinbit injection for the treatment of serious ventricular arrhythmias. It can be synthesized in 3 steps with a final assembly of two ethanolamine blocks. Nifekalant is a non-selective blocker of myocardial repolarizing potassium currents and is completely devoid of any β-adrenergic blocking effect . In hearts from different species, Nifekalant significantly prolonged action potential duration, atrial and ventricular refractory periods in in situ and in isolation studies. In intact animals, hemodynamic parameters were not affected by doses up to 1 mg/kg. The specific characteristics of its voltage- and timedependent K+ current blockade might differentiate Nifekalant from other class III agents currently in use.
Description
Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials. It blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 μM). Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 μM).
Chemical Properties
Yellow Solid
Originator
Mitsui (Japan)
Uses
Nifekalant Hydrochloride is a class III antiarrhythmic agent. Nifekalant Hydrochloride is used in the treatment of patients with extensive anterior infarction and severe ventricular dysfunction.
Definition
ChEBI: Nifekalant hydrochloride is an amine. It contains a Nifekalant.
brand name
Shinbit
Nifekalant hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9177 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28914 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 992 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
View Lastest Price from Nifekalant hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | Nifekalant hydrochloride USP/EP/BP
130656-51-8
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-01-13 | Nifekalant hydrochloride
130656-51-8
|
US $1.00 / KG | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- Nifekalant hydrochloride USP/EP/BP
130656-51-8
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Nifekalant hydrochloride
130656-51-8
- US $1.00 / KG
- 99%
- Career Henan Chemical Co