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Sodium bis(trimethylsilyl)amide

Sodium bis(trimethylsilyl)amide structure

CAS No.: 1070-89-9

Chemical Name:: Sodium bis(trimethylsilyl)amide

Synonyms: NAHMDS;SODIUM HEXAMETHYLDISILAZANE;SODIUM HEXAMETHYLDISILAZIDE;Sodium Bis(trimethylsilyl)amide, 1M THF;HMDS Na;N-SODIOHEXAMETHYLDISILAZANE;Sodiobis(trimethylsilyl)amine;sodium bis(trimethylsilyl)amide solution;NHMDS;HMN NA SALT

CBNumber:: CB8382263

Molecular Formula:: C6H18NNaSi2

Molecular Weight:: 183.37

MDL Number:: MFCD00009835

MOL File:: 1070-89-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:59:17

Product description	Number	Pack Size	Price
Sodium bis(trimethylsilyl)amide solution 1.0?M in THF	245585	100ML	$68.1
Sodium bis(trimethylsilyl)amide solution produced by Wacker Chemie AG, Burghausen, Germany, 40% in THF	80631	500mL	$219
Sodium bis(trimethylsilyl)amide solution 1.0?M in THF	245585	800ML	$315
Sodium bis(trimethylsilyl)amide 95%	235083	5g	$105
Sodium bis(trimethylsilyl)amide 95%	235083	25g	$115
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Sodium bis(trimethylsilyl)amide Properties

Melting point	171-175 °C (lit.)
Boiling point	67°C
Density	0.904 g/mL at 25 °C
Flash point	43 °F
storage temp.	2-8°C
solubility	Soluble in hexane, toluene, ether,terahydrofuran, benzene and toluene.
form	Liquid
Specific Gravity	0.9
color	Clear orange to brown
Water Solubility	reacts
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
BRN	3629917
Exposure limits	ACGIH: TWA 50 ppm; STEL 100 ppm (Skin) OSHA: TWA 200 ppm(590 mg/m3) NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3)
InChI	1S/C6H18NSi2.Na/c1-8(2,3)7-9(4,5)6;/h1-6H3;/q-1;+1
InChIKey	WRIKHQLVHPKCJU-UHFFFAOYSA-N
SMILES	C[Si](C)(C)N([Na])[Si](C)(C)C
CAS DataBase Reference	1070-89-9(CAS DataBase Reference)
EPA Substance Registry System	Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, sodium salt (1070-89-9)
UNSPSC Code	12352111
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363

PPE

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

C,F

Risk Statements

14-34-19-11-67-65-63-48/20-14/15-40-37

Safety Statements

26-45-62-36/37/39-33-16-43-8

RIDADR

UN 3263 8/PG 2

WGK Germany

10-21

TSCA

TSCA listed

HazardClass

4.3

PackingGroup

III

HS Code

29319090

Storage Class

8A - Combustible corrosive hazardous materials

Hazard Classifications

Skin Corr. 1B

Limited Quantities

1.0 L (0.3 gallon) (liquid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	3
3		2
	W

Sodium bis(trimethylsilyl)amide price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	245585	Sodium bis(trimethylsilyl)amide solution 1.0?M in THF	1070-89-9	100ML	$68.1	2026-04-30	Buy
Sigma-Aldrich	80631	Sodium bis(trimethylsilyl)amide solution produced by Wacker Chemie AG, Burghausen, Germany, 40% in THF	1070-89-9	500mL	$219	2026-04-30	Buy
Sigma-Aldrich	245585	Sodium bis(trimethylsilyl)amide solution 1.0?M in THF	1070-89-9	800ML	$315	2026-04-30	Buy
Sigma-Aldrich	235083	Sodium bis(trimethylsilyl)amide 95%	1070-89-9	5g	$105	2023-06-20	Buy
Sigma-Aldrich	235083	Sodium bis(trimethylsilyl)amide 95%	1070-89-9	25g	$115	2023-06-20	Buy

Product number	Packaging	Price	Buy
245585	100ML	$68.1	Buy
80631	500mL	$219	Buy
245585	800ML	$315	Buy
235083	5g	$105	Buy
235083	25g	$115	Buy

Sodium bis(trimethylsilyl)amide Chemical Properties,Uses,Production

Chemical Properties

Slightly yellow to light beige crystalline powder

Physical properties

mp 171–175 °C; bp 170 °C/2 mmHg.

Uses

Sodium bis(trimethylsilyl)amide is a synthetically useful reagent in that it combines both high basicity and nucleophilicity, each of which may be exploited for useful organic transformations such as selective formation of enolates, preparation of Wittig reagents, formation of acyl anion equivalents, and the generation of carbenoid species. As a nucleophile, it has been used as a nitrogen source for the preparation of primary amines.It is useful as a sterically hindered base and as a nucleophile.

Uses

Significantly accelerated the polymerization of pheneylacetylene in conjunction with rhodium (I) catalysis

Uses

It is a strong base; deprotonates ketones and esters to generate enolate derivative.

General Description

Sodium bis(trimethylsilyl)amide solution (NaHMDS) is widely used as a strong base in organic synthesis for deprotonation reactions and base-catalyzed reactions. It is also involved in the generation of enolates, Wittig reagents and carbenes.

Purification Methods

It can be sublimed at 170o/2mm (bath temperature 220-250o) onto a cold finger, and can be recrystallised from *C6H6 (its solubility is: 10g in 100mL at 60o). It is slightly soluble in Et2O and is decomposed by H2O. [Wannagat & Niederprüm Chem Ber 94 1540 1961.]It is available commercially under N2 in Sure/Seal bottles in tetrahydrofuran (various concentrations) and at ~0.6M in toluene. [Beilstein 4 IV 4014.]

Sodium bis(trimethylsilyl)amide Preparation Products And Raw materials

Raw materials

Toluene Sodium Tetrahydrofuran Hexamethyldisilazane

Preparation Products

TERT-BUTYL 4-FORMYLPYRIDIN-3-YLCARBAMATE NONAMETHYLTRISILAZANE TRIS[N,N-BIS(TRIMETHYLSILYL)AMIDE]CERIUM(III)

Sodium bis(trimethylsilyl)amide Suppliers

Global( 433)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi Dideu Medichem Co. Ltd	+8617392709771	1097@dideu.com	China	3996	58
Hebei Yanxi Chemical Co., Ltd.	+8618531123677	faithe@yan-xi.com	China	5853	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5235	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13843	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60

Supplier	Advantage
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60

View Lastest Price from Sodium bis(trimethylsilyl)amide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-31	Sodium bis(trimethylsilyl)amide 1070-89-9	US $20.00 / Kg	500g	1M in THF ; 2M in THF	500g;1kg;5kg;10kg;100kg;1000kg...	Zjartspharm Co., Ltd
2025-12-24	Sodium bis(trimethylsilyl)amide 1070-89-9	US $0.10 / KG	1KG	98.0%	10	Shaanxi Dideu Medichem Co. Ltd
2025-09-25	Sodium bis(trimethylsilyl)amide 1070-89-9	US $6.00-0.60 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

Sodium bis(trimethylsilyl)amide
1070-89-9
US $20.00 / Kg
1M in THF ; 2M in THF
Zjartspharm Co., Ltd

Sodium bis(trimethylsilyl)amide
1070-89-9
US $0.10 / KG
98.0%
Shaanxi Dideu Medichem Co. Ltd

Sodium bis(trimethylsilyl)amide
1070-89-9
US $6.00-0.60 / KG
99%
Henan Fengda Chemical Co., Ltd

Sodium bis(trimethylsilyl)amide Spectrum

Sodium bis(trimethylsilyl)amide(1070-89-9)IR1 Sodium bis(trimethylsilyl)amide(1070-89-9)IR2 Sodium bis(trimethylsilyl)amide(1070-89-9)Raman

1070-89-9(Sodium bis(trimethylsilyl)amide)Related Search:

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N-(Trimethylsilyl)acetamide Lithium bis(trimethylsilyl)amide RINK AMIDE RESIN Trimethylsilylacetylene Sodium hydroxide

Rink Amide Linker Sodium benzoate Sodium acetate Sodium bicarbonate Hexamethyldisiloxane

Bis(triphenylphosphinepalladium) acetate Potassium bis(trimethylsilyl)amide Bis(triphenylphosphine)nickel(II)chloride

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