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3-O-Ethyl-L-ascorbic acid

Chemical Name:
3-O-Ethyl-L-ascorbic acid
ETHYL ASCORBIC ACID;VCE;vitaMin C ethyl ether;VC ethyl ether;3-O-Ethyl Ascorbyl Ether;3-0-Ethyl Ascorbic acid;Ethyl ascorbyl ether;(R)-5-((S)-1,2-dihydroxyethyl)-4-ethoxy-3-hydroxyfuran-2(5H)-one;(5r)-5-[(1s)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-5h-furan-2-one;LGB-VCE
Molecular Formula:
Molecular Weight:
MDL Number:
MOL File:
MSDS File:
Modify Date:2022-08-26 12:09:21

3-O-Ethyl-L-ascorbic acid Properties

Melting point 112.0 to 116.0 °C
Boiling point 551.5±50.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Methanol (Slightly), Water (Slightly)
form Solid
pka 8.89±0.40(Predicted)
color White to Off-White
EWG's Food Scores 1


Risk and Safety Statements

Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338

3-O-Ethyl-L-ascorbic acid price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical E0926 3-O-Ethyl-L-ascorbic Acid >98.0%(HPLC)(T) 86404-04-8 5g $41 2022-04-27 Buy
TCI Chemical E0926 3-O-Ethyl-L-ascorbic Acid >98.0%(HPLC)(T) 86404-04-8 25g $140 2022-04-27 Buy
TRC E922013 3-O-Ethyl-L-ascorbic Acid 86404-04-8 100mg $85 2021-12-16 Buy
AK Scientific W8865 3-O-Ethyl-L-ascorbic Acid 86404-04-8 10g $86 2021-12-16 Buy
Chem-Impex 31932 3-O-Ethyl-L-ascorbicacid,99%(HPLC) 99%(HPLC) 86404-04-8 25G $89.6 2021-12-16 Buy
Product number Packaging Price Buy
E0926 5g $41 Buy
E0926 25g $140 Buy
E922013 100mg $85 Buy
W8865 10g $86 Buy
31932 25G $89.6 Buy

3-O-Ethyl-L-ascorbic acid Chemical Properties,Uses,Production


3-O-Ethyl ascorbic acid ether, also called VC ethyl ether, is an ascorbic acid derivative. Ascorbic acid is a naturally occurring antioxidant and free radical scavenger, a reducing agent in the conversion process of biological enzymes, and has a preventive effect on some chronic diseases (cancer, diabetes and allergic skin diseases). From the molecular structure of ascorbic acid, it can be seen that compared to the 2-position enol hydroxyl group, the 3-position enol hydroxyl group has higher activity on electrophiles, and it is the product of 3-O-alkylation during O-alkylation modification. Mainly. 3-O-Ethyl ascorbate ether is a product of ascorbic acid-3-O-ethylation. It has a simple molecular structure and is easily absorbed by the skin. After entering the dermis through the stratum corneum of the skin, it is easily decomposed by the biological enzymes in the human body. The effect of ascorbic acid effectively solves the fat solubility problem of ascorbic acid, and is widely used in cosmetics as a whitening agent and antioxidant.


Vitamin C ethyl ether (VC ethyl ether) is a lipophilic and hydrophilic amphoteric vitamin C derivative. It not only retains the redox effect of vitamin C but is also very stable. It is a non-discoloring vitamin C derivative. It is a lipophilic and chemicalbook amphoteric substance, which not only makes it extremely convenient to use in the formula, but also makes it easy to penetrate the stratum corneum into the dermis. After entering the skin, it is easily decomposed by biological enzymes to play the role of vitamin C, thereby Improve its bioavailability.


3-O-Ethyl-L-ascorbic Acid could be a useful stabilizing agent for a para-hydroxyacetophenone solution. 3-O-Ethyl-L-ascorbic Acid could be a useful stabilizing agent for a para-?hydroxyacetophenone solution.

Mechanism of action

VC ethyl ether penetrates the stratum corneum to reach the melanocytes in the basal layer, inhibits tyrosinase activity, inhibits the formation of melanin, and restores melanin to colorless, thereby effectively whitening the skin. And Chemicalbook and VC ethyl ether can directly participate in the synthesis of collagen and repair skin cell activity after entering the dermis, increasing collagen, so that the skin becomes full and elastic, making the skin delicate and smooth.


The above 3-O-ethyl-5,6-O-isopropylideneascorbic acid 40g dissolved in 200ml of ethanol. 10g of cation-exchange resin was added and was refluxed for 2 hours. The catalyst was removed by an ion exchange resin and concentrated under reduced pressure. After drying, with ethyl acetate: hexane (3: 1) crystallization. After drying, obtained 33.3g 3-O-ethylascorbic acid, yield 94%. It was recrystallized in 100mL ethyl acetate giving 30.6g, yield 87%, mp: 112-114°C.

Synthesis of 3-O-Ethyl-L-ascorbic acid from L-Ascorbic acid, 3-O-ethyl-5,6-O-(1-methylethylidene)-

3-O-Ethyl-L-ascorbic acid Preparation Products And Raw materials

Global( 486)Suppliers
Supplier Tel Email Country ProdList Advantage
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616 CHINA 9412 58
532-83657313 China 228 58
Jinan Jianfeng Chemical Co., Ltd
+8615562555968 China 236 58
Baoji Guokang Healthchem co.,ltd
+8615604608665 15604608665 CHINA 9453 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 China 29803 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 16708 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 China 22021 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 China 9404 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479 CHINA 890 55
Anhui Royal Chemical Co., Ltd.
+86-25-86655873 +8613962173137 China 536 55

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View Lastest Price from 3-O-Ethyl-L-ascorbic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2022-08-26 3-O-Ethyl-L-ascorbic acid
US $100.00 / kg 1kg 99% 100 tons Hebei Duling International Trade Co. LTD
2022-06-16 3-O-Ethyl-L-ascorbic acid
US $20.00 / kg 10kg 99% 20tons Hebei Linwo New Material Technology Co., LTD
2022-04-26 3-O-Ethyl-L-ascorbic acid
US $1.00 / kg 1kg 99% 1 tons Jiangsu Bangdeya New Material Technology Co.,Ltd
3-O-Ethyl-L-ascorbic Acid 3-o-ethyl-l-ascorbic acid 3-O-ETHYLASCORBICACID (5R,1'S)-5-(1,2-Dihydroxy-ethyl)-4-ethoxy-3-hydroxy-5H-furan-2-one (5R)-5-(1,2-dihydroxyethyl)-4-ethoxy-3-hydroxy-2,5-dihydrofuran-2-one (5R)-5-[(1S)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxyfuran-2(5H)-one (non-preferred naMe) 3-O-Ethyl vitaMin C ester Only VCE 3-O-Ethyl-Lascorbicaci 3-O-Ethyl-L-ascorbic Acid, >=99% (5R,1'S)-5-(1,2-Dihydroxy-ethyl)-4-e 3-O-Ethyl-L-ascorbic acid VC ethyl ether Nano Liposomal 3-o-ETHYL ASCORBICACID 3-O-Ethyl-L-ascorbic ETHYL ASCORBIC 3-O-Ethylascorbate Ethyl Vitamin C LGB-VCE 3-o-EthyL 3-O-Ethyl-L-ascorbicAcid> L-Ascorbic acid, 3-O-ethyl- 3-O-Ethyl-L-ascorbic acid fandachem 3-O-ethyl-l-ascorbic acid?(EA) 3-o-ETHHYL ASCORBIC ACID Skin Whitening VCE 3-O-Ethyl-L-ascorbic acid USP/EP/BP 3-O-Ethyl-L-ascorbic acid cas 86404-04-8 High Quality 3-O-Ethyl-L-Ascorbic Acid API with CAS: 86404-04-8 3-O-Ethyl Ascorbyl Ether ETHYL ASCORBIC ACID (5r)-5-[(1s)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-5h-furan-2-one (R)-5-((S)-1,2-dihydroxyethyl)-4-ethoxy-3-hydroxyfuran-2(5H)-one VC ethyl ether vitaMin C ethyl ether VCE Ethyl ascorbyl ether 3-0-Ethyl Ascorbic acid 86404-04-8 85404-04-8 86404-04-0 Vitamine C derivative API 86404-04-8