4-Amino-1-Boc-piperidine
- CAS No.
- 87120-72-7
- Chemical Name:
- 4-Amino-1-Boc-piperidine
- Synonyms
- TERT-BUTYL 4-AMINOPIPERIDINE-1-CARBOXYLATE;1-BOC-4-AMINOPIPERIDINE;N-BOC-4-AMINOPIPERIDINE;1-BUTYLOXYCARBONYL-4-AMINO-PIPERIDINE;4-Amino-piperidine-1-carboxylic acid t-butyl ester;4-AMINO-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;EOS-61525;1-BOC-4-AMI;BOC-PIP(4-NH2);BUTTPARK 90\06-10
- CBNumber:
- CB8758747
- Molecular Formula:
- C10H20N2O2
- Molecular Weight:
- 200.28
- MDL Number:
- MFCD01076201
- MOL File:
- 87120-72-7.mol
- MSDS File:
- SDS
| Melting point | 50°C |
|---|---|
| Boiling point | 80/0.037mm |
| Density | 1.041±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 10.10±0.20(Predicted) |
| form | Crystalline Powder, Crystals and/or Chunks |
| color | White to pale yellow to beige |
| Water Solubility | Insoluble in water. |
| Sensitive | Air Sensitive |
| InChI | InChI=1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-8(11)5-7-12/h8H,4-7,11H2,1-3H3 |
| InChIKey | LZRDHSFPLUWYAX-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(N)CC1 |
| CAS DataBase Reference | 87120-72-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-37/38-41-36/37/38-20/21/22-20/21/2236/37/38 | |||||||||
| Safety Statements | 26-36/37/39-22-222636/37/39 | |||||||||
| RIDADR | 3259 | |||||||||
| WGK Germany | 2 | |||||||||
| F | 10-34 | |||||||||
| Hazard Note | Irritant | |||||||||
| TSCA | N | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
4-Amino-1-Boc-piperidine Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
4-Amino-1-Boc-piperidine is a potent inhibitor of the CCR5 receptor. It is an x-ray crystal structure with a hydroxide solution that inhibits the growth of cancer cells. The inhibitor binding site for 4-Amino-1-Boc-piperidine was determined to be the CCR5 receptor, which is located on the surface of hematopoietic cells. The compound has been shown to inhibit human T lymphocyte proliferation in vitro and inhibit HIV replication in infected patients. 4-Amino-1-Boc-piperidine is able to inhibit the growth of cancer cells by blocking the production of cytokines, such as interleukin 2, that are needed for cell division and growth.
Uses
4-Amino-1-Boc-piperidine is a chemical reagent used in the preparation of pharmaceutical compounds. Used in the synthesis of bromodomain inhibitors as well as HepG2 cell cycle inhibitors used in anti-tumor therapy. Also employed in a microwave-assisted solid-phase synthesis of N-substituted piperidines via direct annulation of primary amines with resin-bound dimesylates.
Application
4-Amino-1-Boc-piperidine is a pharmaceutical intermediate is applied in the treatment of anti-tumor and other drugs. It is an important fine chemical intermediate and has a wide range of uses in the pharmaceutical industry.
4-Amino-1-Boc-piperidine Preparation Products And Raw materials
Raw materials
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