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Finasteride

Indications and Usage Mechanisms of Action
Finasteride
Finasteride structure
CAS No.
98319-26-7
Chemical Name:
Finasteride
Synonyms
MK-906;Andozac;mk-0906;Fistide;PROSCAR;PROSTIDE;FINASTID;l-652,931;Finastride;Prosteride
CBNumber:
CB9433852
Molecular Formula:
C23H36N2O2
Formula Weight:
372.54
MOL File:
98319-26-7.mol

Finasteride Properties

Melting point:
253 °C
alpha 
405 -59° (c = 1 in methanol)
Boiling point:
576.6±50.0 °C(Predicted)
Density 
1.065±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: 32 mg/mL, soluble
pka
14.17±0.70(Predicted)
form 
solid
color 
white to beige
Water Solubility 
insoluble
Merck 
14,4082
InChIKey
DBEPLOCGEIEOCV-WSBQPABSSA-N
CAS DataBase Reference
98319-26-7(CAS DataBase Reference)
FDA UNII
57GNO57U7G
NCI Dictionary of Cancer Terms
finasteride
EPA Substance Registry System
1H-Indeno[5,4-f]quinoline-7-carboxamide, N-(1,1-dimethylethyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)- (98319-26-7)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330-P264-P270-P301+P312a-P330-P501a
Hazard Codes  Xn,T,Xi
Risk Statements  22-61-60-36/37/38
Safety Statements  36/37/39-45-53-36-26-24/25
WGK Germany  3
RTECS  CL5245000
HS Code  29379000

Finasteride price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 34202 Finasteride VETRANAL 98319-26-7 100mg $154 2019-12-02 Buy
Sigma-Aldrich 1270402 Finasteride United States Pharmacopeia (USP) Reference Standard 98319-26-7 200mg $352.8 2019-12-02 Buy
TCI Chemical F0675 Finasteride >98.0%(GC) 98319-26-7 200mg $54 2020-06-24 Buy
TCI Chemical F0675 Finasteride >98.0%(GC) 98319-26-7 1g $159 2020-06-24 Buy
Alfa Aesar J63454 Finasteride 98319-26-7 1g $171 2020-06-24 Buy

Finasteride Chemical Properties,Uses,Production

Indications and Usage

Finasteride is a basic drug to treat benign prostatic hyperplasia and prostatitis, a synthetic 4-nitrogen steroid hormone compound and a sex hormone drug.
It is used for benign prostatic hyperplasia, men's prostatic fat and other diseases. Finasteride is the only oral drug approved by the US Food and Drug Administration (FDA) to treat male pattern baldness.

Mechanisms of Action

Finasteride can selectively inhibit 5α-reductase, changing the conversion process of testosterone into 5α dihydrotestosterone (DHT), decreasing androgen levels in prostate cells, and prostate-specific antigens in serum, decreasing prostate swelling, and increasing urine flow rate, thereby alleviating the symptoms of prostatic hyperplasia. It acts by selectively blocking androgen stimulation of the prostate, but affects sexual function very rarely. Meanwhile, due to blocking of testosterone conversion and reduced synthesis of dihydrotestosterone, it can reduce dihydrotestosterone levels in the serum and scalp hair follicles, recovering the function of previously inhibited hair follicles, promoting hair growth and preventing loss.

Description

Finasteride, a novel 4-azasteroid, is a breakthrough in the treatment and control of benign prostatic hyperplasia. Mechanistically, it inhibits the prostatic-specific enzyme 5-alpha reductase, thereby decreasing the conversion of testosterone to dihydrotestosterone. It is reportedly effective in reducing urinary symptoms and prostatic volume and increasing maximal urinary flow rate. Finasteride is also being investigated as a treatment for prostatic cancer.

Chemical Properties

Off-White Crystalline Powder

Originator

Merck (U.S.A.)

Uses

Inhibitor of 5a-reductase, the enzyme which converts testosterone to the more potent androgen, 5a-dihydrotestosterone. Antialopecia agent

Uses

Inhibitor of 5α-reductase, the enzyme which converts testosterone to the more potent androgen, 5α-dihydrotestosterone. Antialopecia agent.

Uses

anti-androgen, alpha-reductase inhibitor

Uses

Treatment of benign prostatic hyperplasia and androgenetic alopecia

Definition

ChEBI: An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia.

Indications

Finasteride (Proscar) is a 5-reductase inhibitor that blocks the conversion of testosterone to DHT in target tissues. Since DHT is the major intracellular androgen in the prostate, finasteride is effective in suppressing DHT stimulation of prostatic growth and secretory function without markedly affecting libido. It is approved for the treatment of benign prostatic hyperplasia. Although there is usually some regression in the size of the prostate gland following administration of finasteride, clinical response may take 6 to 12 months. If the obstructive symptoms are severe, there is often not enough time to allow this compound to work.The principal adverse effects of finasteride are impotence, decreased libido, and decreased volume of ejaculate. The compound is generally well tolerated in men.

brand name

Proscar

Biological Activity

Antiandrogen that inhibits type II 5 α reductase (IC 50 = 65 nM). Suppresses the conversion of testosterone to dihydrotestosterone. Reduces prostatic dihydrotestosterone levels and prostate size in vivo . Orally active.

Veterinary Drugs and Treatments

Finasteride may be useful in treating the benign prostatic hypertrophy in canine patients. Because of the drug’s relative expense and the long duration of therapy required to see a response, its usefulness may be limited in veterinary medicine.
It may also be useful in the adjunctive treatment of adrenal disease in ferrets.

Finasteride Preparation Products And Raw materials

Raw materials

Preparation Products


Finasteride Suppliers

Global( 401)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Payne Pharmaceutical Technology Co.Ltd
18678586262 021-58123769
info@paynepharm.com China 1354 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales03@yibaibiotech.com CHINA 420 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3050 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2406 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58

View Lastest Price from Finasteride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-07-03 Exemestan
107868-30-4
US $120.00 / ASSAYS 10ASSAYS 99.6% 600kg/month Hebei Huanhao Biotechnology Co., Ltd.
2020-07-03 Finasteride
98319-26-7
US $120.00 / ASSAYS 10ASSAYS 99.5% 500KG/MONTH Hebei Huanhao Biotechnology Co., Ltd.
2020-05-08 Finasteride
98319-26-7
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd

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