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Cefoxitin

Cefoxitin
Cefoxitin structure
CAS No.
35607-66-0
Chemical Name:
Cefoxitin
Synonyms
cfx;C06887;Mefoxin;CEFOXITIN;Rephoxitin;cephoxitin;CEFOXITIN ACID;Cefoxitin (500 mg);Cefoxitin(Mefoxin);Cefoxitin Solution, 100ppm
CBNumber:
CB9490581
Molecular Formula:
C16H17N3O7S2
Formula Weight:
427.45
MOL File:
35607-66-0.mol

Cefoxitin Properties

Melting point:
149-150℃
Boiling point:
843℃
Density 
1.4441 (rough estimate)
refractive index 
1.6390 (estimate)
RTECS 
XI0386500
Flash point:
>110°(230°F)
pka
2.2(at 25℃)
Water Solubility 
Predicted solubility in water is less than 0.2mg/ml
CAS DataBase Reference
35607-66-0(CAS DataBase Reference)
EPA Substance Registry System
5-Thia-1-azabicyclo[ 4.2.0]oct-2-ene-2-carboxylic acid, 3-[[(aminocarbonyl)oxy]methyl]- 7-methoxy-8-oxo-7-[(2-thienylacetyl) amino]-, (6R,7S)-(35607-66-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
RIDADR  3077
HazardClass  9
PackingGroup  III
HS Code  30032013
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P321 Specific treatment (see … on this label).
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.

Cefoxitin price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J66891 Cefoxitin, 98% 35607-66-0 1g $121 2018-11-13 Buy

Cefoxitin Chemical Properties,Uses,Production

Uses

Antibacterial.

brand name

Mefoxin (Merck).

Antimicrobial activity

Most Gram-positive bacilli are susceptible, but L. monocytogenes is resistant. It is resistant to many Gramnegative β-lactamases and is active against organisms elaborating them, including some Citrobacter, Providencia, Serratia and Acinetobacter spp. Enterobacter spp. are resistant. It is moderately active against Bacteroides spp., but considerable strain variation in susceptibility occurs.

Acquired resistance

Resistant strains of Bacteroides, some of which produce β-lactamases that hydrolyze cefoxitin, have been described. Resistance may be transferable to other Bacteroides spp. It is a potent inducer of chromosomal cephalosporinases of certain Gram-negative bacilli and can antagonize the effect of cefotaxime and other β-lactam agents.

Pharmacokinetics

Cmax 500 mg intramuscular: 11 mg/L after 20 min
1 g intravenous: c. 150 mg/L end injection
Plasma half-life: 0.7–1 h
Volume of distribution: c. 10 L
Plasma protein binding: 65–80%
Absorption
It is not absorbed when given orally, but is very rapidly absorbed from intramuscular sites. Doubling the dose approximately doubles the plasma level. It is absorbed from suppositories to varying degrees depending on the adjuvants: peak serum levels around 9.8 mg/L have been obtained after a dose of 1 g, giving a bioavailability of around 20%. In infants and children treated with 150 mg/kg per day, mean serum concentrations 15 min after intravenous and intramuscular administration were 81.9 and 68.5 mg/L, with elimination half-lives of 0.70 and 0.67 h, respectively.
Distribution
About 20% of the corresponding serum levels are found in sputum. In patients given 1 g by intravenous bolus preoperatively, concentrations in lung tissue at 1 h were around 13 mg/g. Penetration into normal CSF is very poor; even in patients with purulent meningitis CSF concentrations seldom exceed 6 mg/L. In children with meningitis receiving 75 mg/kg every 6 h, peak concentrations of 5–6 mg/L were found around 1 h after the dose. In patients receiving 2 g intravenously before surgery, the mean penetrance into peritoneal fluid was 86%. In patients receiving 2 g intramuscularly before hysterectomy, mean concentrations in pelvic tissue were 7.8 mg/g. Breast milk contained 5–6 mg/L after a 1 g intravenous dose. Concentrations up to 230 mg/L have been found in bile after 2 g intravenously.
Metabolism and excretion
Less than 5% of the drug is desacetylated and in a few subjects deacylation of 1 or 2% of the dose to the antibacterially inactive descarbamyl form also occurs.
It is almost entirely excreted in the urine by both glomerular filtration and tubular secretion, 80–90% being found in the first 12 h after a parenteral dose, producing concentrations in excess of 1 g/L. Furosemide, in doses of 40–160 mg, had no effect on the elimination half-life of doses of 1 or 2 g. Probenecid delays the plasma peak and decreases the renal clearance and urine concentration. The renal clearance has been calculated variously to lie between 225 and 330 mL/ min. The plasma half-life increases inversely with creatinine clearance to reach 24 h in oliguric patients, with corresponding reduction in total body clearance. In patients on peritoneal dialysis, peritoneal clearance accounted for only 7.5% of mean plasma clearance and the mean plasma half-life during 6 h dialysis was 7.8h.

Clinical Use

As for other group 3 cephalosporins, with particular emphasis on mixed infections including anaerobes, notably abdominal and pelvic sepsis. In considering its use, its low activity against aerobic Gram-positive cocci should be noted.

Side effects

Reactions are those common to cephalosporins. Pain on intramuscular, and thrombophlebitis on intravenous, injection occur. Substantial changes can occur in the fecal flora, with virtual eradication of susceptible enterobacteria and non- fragilis Bacteroides, and appearance of, or increase in, yeasts, enterococci and other resistant bacteria including C. difficile. Development of meningitis due to H. influenzae and Str. pneumoniae in patients treated for other infections has been observed.

Cefoxitin Preparation Products And Raw materials

Raw materials

Preparation Products


Cefoxitin Suppliers

Global( 119)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
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+86-0592-6210733 sales@mainchem.com CHINA 32457 55
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025-85710122 sales@fine-chemtech.com CHINA 892 55
Chemwill Asia Co.,Ltd.
86-21-51086038
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J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
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Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550
+86-418-6502885 lnthhg@thflu.com China 338 69
BePharm Ltd 4001-647-117; 021-61629020
021-61629029 product@bidepharmatech.com China 24689 61
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1943 70
Nanjing Chemlin Chemical Co., Ltd 025-83697070
+86-25-83453306 sales@chemlin.com.cn China 19983 64

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