rac-(R*)-1-(3-クロロフェニル)-2-[(1,1-ジメチルエチル)アミノ]-1-プロパノン/塩酸,(1:1)

rac-(R*)-1-(3-クロロフェニル)-2-[(1,1-ジメチルエチル)アミノ]-1-プロパノン/塩酸,(1:1) 化学特性,用途語,生産方法

化学的特性

Bupropion hydrochloride powder is white, crystalline, and highly soluble in water. It has a bitter taste and produces the sensation of local anesthesia on the oral mucosa.

薬物相互作用

Relatively few data are available on interactions of bupropion hydrochloride with other drugs. Increased adverse experiences were reported when the drug was administered concomitantly with l-dopa. MAOIs may increase the acute toxicity of bupropion.
Although bupropion is not metabolized by the CYP2D6 enzyme, the drug and its metabolite, morpholinol, inhibit this enzyme in vitro. Therefore, extreme caution should be exercised when coadministering any drug metabolized by that enzyme, and initial dosage of the drug should be as low as possible.

使用

Bupropion hydrochloride is indicated for the treatment of MDD. Bupropion hydrochloride SR (Zyban) is indicated as an aid to smoking cessation treatment.

生物活性

Non-selective inhibitor of dopamine and noradrenalin transporters (K i values are 1.4, 2.8 and 45 μ M for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo .

副作用

Bupropion hydrochloride can cause serious side effects. The most common side effects of Bupropion hydrochloride include:
headache
dizziness
dry mouth
sore throat
nausea
constipation
trouble sleeping

Mode of action

The exact mechanism of the antidepressant action of bupropion is not known, but is presumed to be related to noradrenergic and/or dopaminergic mechanisms. Bupropion is a relatively weak inhibitor of the neuronal reuptake of norepinephrine and dopamine, and does not inhibit the reuptake of serotonin. Bupropion does not inhibit monoamine oxidase.

rac-(R*)-1-(3-クロロフェニル)-2-[(1,1-ジメチルエチル)アミノ]-1-プロパノン/塩酸,(1:1) 上流と下流の製品情報

原材料

準備製品

31677-93-7(rac-(R*)-1-(3-クロロフェニル)-2-[(1,1-ジメチルエチル)アミノ]-1-プロパノン/塩酸,(1:1))キーワード:

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• (+-)-alpha-tert-butylamino-3-chloropropiophenonehydrochloride
• 1-propanone,1-(3-chlorophenyl)-2-((1,1-dimethylethyl)amino)-,hydrochloride,
• 2-(tert-butylamino)-3’-chloro-,hydrochloride,(+-)-propiophenon
• Bupropion hydrochloride,(±)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
• Bupropion Hydrochloride (200 mg)
• m-chloro-alpha-tert-butylaminoprophenonehydrochloride
• wellbatrin
• Bupropion Hydrochloride, USP
• Bupropiob hydrochloride
• 2-(tert-butylaMino)-1-(3-chlorophenyl)propan-1-one HCl
• AMfebutaMone (Bupropion)
• AMfebutaMon Hydrochloride
• Aplenzin Hydrochloride
• Bupropion SR Hydrochloride
• Elontril Hydrochloride
• α-(tert-ButylaMino)-M-chloropropiophenone Hydrochloride
• Bupropion HCl API
• 2-(tert-Butylamino)-1-(3-chlorophenyl)-1-propanone Hydrochloride Amfebutamone Hydrochloride
• Bupropion hydrochloride(AMfebutaMone hydrochloride)
• bupropion hydrochloride/bupropion
• bupropio hydrochloride
• Bupropion Hydrochloride (1.0 Mg/ML in Methanol)
• 1-(3-chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone,hydrochloride (1:1)
• Amfebutamone (Bupropion) HCl
• Bupropion hydrochloride solution
• Bupropion Hydrochloride (150 mg)
• BUPROPION HYDROCHLORIDE SUSTAINED-RELEASE TABLETS
• Bupropion hydrochlorid
• BUPROPION HCL
• DL-1-(3-CHLOROPHENYL)-2-[(1,1-DIMETHYLETHYL)AMINO]-1-PROPANONE HYDROCHLORIDE
• ウェルバトリン
• アンフェブタモン塩酸塩
• 塩酸ブプロピオン
• (±)-1-(3-クロロフェニル)-2-[(1,1-ジメチルエチル)アミノ]-1-プロパノン塩酸塩
• rac-(R*)-1-(3-クロロフェニル)-2-[(1,1-ジメチルエチル)アミノ]-1-プロパノン/塩酸,(1:1)
• ブプロピオン塩酸塩
• ウェルブトリン