メタンスルホニルクロリド 化学特性,用途語,生産方法
外観
無色～うすい黄色, 澄明の液体
溶解性
水に難溶。エタノール, アセトン, エーテルに易溶。エタノール及びアセトンに極めて溶けやすい。水により徐々に、熱水で容易にメタンスルホン酸と塩酸に分解する。
用途
主要な用途は、難燃化剤、写真関連、線維染料、農業用化学製品、製薬における合成中間体であり、安定化剤、触媒、硬化剤、塩素化剤として使用される。
化学的特性
Colorless to yellow liquid
使用
Methanesulfonyl chloride is used as a reagent for conversion of alcohols to mesylate esters such as methanesulfonate, which is an intermediate in substitution reactions, elimination reactions, reductions, and rearrangement reactions viz. Beckmann rearrangement. It is an electrophile and acts as a source of CH3SO2+ group. It is also used to prepare beta-chloro sulfones, methanesulfonamide and heterocyclic compounds containing five membered sultones.
一般的な説明
A pale yellow corrosive liquid. More dense than water and insoluble in water. Very toxic by ingestion, inhalation, or skin absorption.
反応プロフィール
Methanesulfonyl chloride reacts vigorously with water, steam, alkali, methylformamide. Emits toxic fumes of chloride and oxides of sulfur when heated to decomposition. A dangerous storage hazard. Reacts explosively with dimethyl sulfoxide [Buckley, A., J. Chem. Educ., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
健康ハザード
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
火災危険
Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
職業ばく露
Chemical intermediate in various
industries including pesticides, flame retardants, pharmaceuticals, plastics. A solvent, curing agent, and chemical
stabilizer. Laboratory chemical.
輸送方法
UN3246 Methanesulfonyl chloride, Hazard Class
6.1; Labels: 6.1-Poison Inhalation Hazard, 8-Corrosive
material, Inhalation Hazard Zone B.
純化方法
Distil the sulfonyl chloride from P2O5 under vacuum. It is a strong IRRITANT.[Beilstein 4 IV 27.]
不和合性
Vapors may form explosive mixture with
air. Slowly reacts with water, releasing toxic and corrosive
hydrogen chloride gas. Incompatible with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may cause fires
or explosions. Keep away from alkaline materials, DMSO,
ethers, strong acids, strong bases.
廃棄物の処理
Use a licensed professional
waste disposal service to dispose of this material. Dissolve
or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner
and scrubber. All federal, state, and local environmental
regulations must be observed
メタンスルホニルクロリド 上流と下流の製品情報
原材料
準備製品
ニメスリド
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-phosphate piperazine salt
アズトレオナム
2-N-(メタンスルホンアミド)フェニルボロン酸
アムサクリン
ラロキシフェン
プロパンスルトン
5-アミノサリチル酸
1-(Tetrahydro-2H-pyran-4-yl)hydrazine
ブスルファン
(4S)-4-hydroxy-3-methyl-2-prop-2-ynyl-cyclopent-2-en-1-one
5,5'-アゾビスサリチル酸
メタンスルホンアミド
(2R,3R)-(-)-1,4-ビス(ジフェニルホスフィノ)-2,3-O-イソプロピリデン-2,3-ブタンジオール
S-1108
3-(メタンスルホニルアミノ)安息香酸
メタンスルホン酸メチル
ゲストデン
ペルゴリド
メタンスルホン酸エチル
プロピオン酸ハロベタゾール
サニルブジン
(メチルスルホニル)酢酸エチル
N-(4-アミノフェニル)メタンスルホンアミド
フェキソフェナジン
TERT-BUTYL 4-(AMINOMETHYL)PYRIDIN-2-YLCARBAMATE
(2-TERT-BUTOXYFORMAMIDO-PYRIDIN-4-YL)METHYL METHANESULFONATE
3-(tert-ブトキシカルボニルアミノ)ピロリジン
(S)-2-メチル-3-アリル-4-オキソ-2-シクロペンテン-1-オール
4,5-ジフルオロアントラニル酸
4-[(メチルスルホニル)アミノ]安息香酸
11β,17-ジヒドロキシ-21-[(メチルスルホニル)オキシ]プレグナ-1,4-ジエン-3,20-ジオン
サペルコナゾール
alkyl phenylsufonate
N-(3-アミノフェニル)メタンスルホンアミド
optically active amino thioacetes
(3S,4S)-(-)-1-BENZYL-3,4-BIS(DIPHENYLPHOSPHINO)PYRROLIDINE
(S,S)-BPPM
(3S)-(-)-3-(tert-ブトキシカルボニルアミノ)ピロリジン
リマプロスト