메탄설포닐 클로라이드 C화학적 특성, 용도, 생산
화학적 성질
Colorless to yellow liquid
용도
Methanesulfonyl chloride is used as a reagent for conversion of alcohols to mesylate esters such as methanesulfonate, which is an intermediate in substitution reactions, elimination reactions, reductions, and rearrangement reactions viz. Beckmann rearrangement. It is an electrophile and acts as a source of CH3SO2+ group. It is also used to prepare beta-chloro sulfones, methanesulfonamide and heterocyclic compounds containing five membered sultones.
일반 설명
A pale yellow corrosive liquid. More dense than water and insoluble in water. Very toxic by ingestion, inhalation, or skin absorption.
반응 프로필
Methanesulfonyl chloride reacts vigorously with water, steam, alkali, methylformamide. Emits toxic fumes of chloride and oxides of sulfur when heated to decomposition. A dangerous storage hazard. Reacts explosively with dimethyl sulfoxide [Buckley, A., J. Chem. Educ., 1965, 42, p. 674]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
건강위험
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
화재위험
Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
잠재적 노출
Chemical intermediate in various
industries including pesticides, flame retardants, pharmaceuticals, plastics. A solvent, curing agent, and chemical
stabilizer. Laboratory chemical.
운송 방법
UN3246 Methanesulfonyl chloride, Hazard Class
6.1; Labels: 6.1-Poison Inhalation Hazard, 8-Corrosive
material, Inhalation Hazard Zone B.
Purification Methods
Distil the sulfonyl chloride from P2O5 under vacuum. It is a strong IRRITANT.[Beilstein 4 IV 27.]
비 호환성
Vapors may form explosive mixture with
air. Slowly reacts with water, releasing toxic and corrosive
hydrogen chloride gas. Incompatible with oxidizers
(chlorates, nitrates, peroxides, permanganates, perchlorates,
chlorine, bromine, fluorine, etc.); contact may cause fires
or explosions. Keep away from alkaline materials, DMSO,
ethers, strong acids, strong bases.
폐기물 처리
Use a licensed professional
waste disposal service to dispose of this material. Dissolve
or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner
and scrubber. All federal, state, and local environmental
regulations must be observed
메탄설포닐 클로라이드 준비 용품 및 원자재
원자재
준비 용품
Nimesulide
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione21-phosphate piperazine salt
아조트리오남
2-(Methanesulfonylamino)phenylboronic acid
암사크린
Raloxifene
프로페인 설톤
5-아미노셀릭일 산
1-(Tetrahydro-2H-pyran-4-yl)hydrazine
부설판
(4S)-4-hydroxy-3-methyl-2-prop-2-ynyl-cyclopent-2-en-1-one
OLSALAZINE
Methanesulfonamide
(-)-DIOP
Cefcapene pivoxil
3-(METHANESULFONYLAMINO)BENZOIC ACID
메탄술폰산메틸에스테르
제스토덴
Pergolide
메탄술폰산에틸에스테르
Halobetasol propionate
Stavudine
ETHYL METHANESULFONYLACETATE
4-(Methylsulfonamido)aniline
Fexofenadine
TERT-BUTYL 4-(AMINOMETHYL)PYRIDIN-2-YLCARBAMATE
(2-TERT-BUTOXYFORMAMIDO-PYRIDIN-4-YL)METHYL METHANESULFONATE
3-(보크-아미노)피롤리딘
(4S)-HYDROXY-3-METHYL-2-(2-PROPENYL)-2-CYCLOPENTENE-1-ONE
2-Amino-4,5-difluorobenzoic acid
4-(METHANESULFONYLAMINO)BENZOIC ACID
11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-methanesulphonate
SAPERCONAZOLE
alkyl phenylsufonate
N-(3-Aminophenyl)methanesulfamide
optically active amino thioacetes
(3S,4S)-(-)-1-벤질-3,4-비스(디페닐포스피노)피롤리딘
(2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine
(S)-3-(Boc-아미노)피롤리딘
LIMAPROST