ChemicalBook
Chinese english Germany Korea

L-メチオニン

L-メチオニン 化学構造式
63-68-3
CAS番号.
63-68-3
化学名:
L-メチオニン
别名:
L-メチオニン;(S)-4-(メチルチオ)-2-アミノ酪酸;(S)-2-アミノ-4-(メチルチオ)ブタン酸;(-)-メチオニン;(S)-メチオニン;(-)-L-メチオニン;L-メチオニンZ;メチオニン;Lメチオニン;L‐メチオニン;L‐メチオニン CRM6023‐A;メチオニン, U.S.P.;メチオニン, L-;メチオニン, research grade, Ph. Eur.;L-メチオニン (JP17);L-メチオニン 1
英語化学名:
L-Methionine
英語别名:
MET;L-MET;lactet;L-Met-OH;H-MET-OH;Acimethin;Cymethion;Liquimeth;NSC 22946;METHIONINE
CBNumber:
CB9208759
化学式:
C5H11NO2S
分子量:
149.21
MOL File:
63-68-3.mol

L-メチオニン 物理性質

融点 :
284 °C (dec.)(lit.)
比旋光度 :
23.25 º (c=2, 6N HCl)
沸点 :
393.91°C (estimate)
比重(密度) :
1,34g/cm
屈折率 :
1.5216 (estimate)
貯蔵温度 :
Store at RT.
溶解性:
1 M HCl: 0.5 M at 20 °C, clear, colorless
外見 :
Solid
酸解離定数(Pka):
2.13(at 25℃)
色:
White
PH:
5-7 (10g/l, H2O, 20℃)
光学活性 (optical activity):
[α]20/D +23.7±0.5°, c = 5% in 5 M HCl
水溶解度 :
Soluble
極大吸収波長 (λmax):
λ: 260 nm Amax: 0.40
λ: 280 nm Amax: 0.05
Merck :
14,5975
BRN :
1722294
安定性::
Stable. Incompatible with strong oxidizing agents.
CAS データベース:
63-68-3(CAS DataBase Reference)
NISTの化学物質情報:
L-Methionine(63-68-3)
EPAの化学物質情報:
L-Methionine (63-68-3)

安全性情報

Rフレーズ  33
Sフレーズ  24/25
WGK Germany  2
RTECS 番号 PD0457000
10-23
TSCA  Yes
HSコード  29304010
有毒物質データの 63-68-3(Hazardous Substances Data)
毒性 LD50 oral in rat: 36gm/kg
化審法 (2)-1254 届出不要化学物質

L-メチオニン 価格 もっと(67)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00013256 メチオニン, L-
Methionine, L-
63-68-3 1g ¥2100 2020-09-21 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00013256 メチオニン, L-
Methionine, L-
63-68-3 100mg ¥13400 2018-12-26 購入
東京化成工業 M0099 L-メチオニン >99.0%(T)
L-Methionine >99.0%(T)
63-68-3 100g ¥6500 2020-09-21 購入
東京化成工業 M0099 L-メチオニン >99.0%(T)
L-Methionine >99.0%(T)
63-68-3 25g ¥2500 2020-09-21 購入
関東化学株式会社(KANTO) 16616-2A L‐メチオニン
L‐Methionine
63-68-3 25g ¥3300 2020-09-21 購入

L-メチオニン MSDS


L-Methionine

L-メチオニン 化学特性,用途語,生産方法

外観

白色, 結晶~結晶性粉末

定義

本品は、次の化学式で表されるアミノ酸である。

溶解性

水100gに3g (0℃), 5.6g (30℃)溶解。有機溶媒に不溶。酸, アルカリ溶液に可溶。水にやや溶けやすく、エタノールに極めて溶けにくく、ジエチルエーテルにほとんど溶けない。塩酸又は水酸化ナトリウム溶液に溶ける。

化粧品の成分用途

ヘアコンディショニング剤、皮膚コンディショニング剤

効能

解毒薬

説明

Colorless or white lustrous plates, or a white crystalline powder. It has a slight, characteristic odor. It is soluble in water, in alkali solutions, and in dilute mineral acids. It is slightly soluble in alcohol and practically insoluble in ether.

化学的特性

White crystalline powder

化学的特性

Methionine occurs as a white or almost white, crystalline powder or colorless crystals.

Originator

Meonine ,Ives,US,1944

使用

methionine is slows down and normalizes oil gland sebum production. Methionine is also used as a texturizer in cosmetic creams. It is an essential amino acid found in a number of proteins and obtained by means of fermentation.

使用

Essential aminoacid for human development. Hepatoprotectant; antidote (acetominophen poisoning); urinary acidifier.

定義

ChEBI: The L-enantiomer of methionine.

調製方法

Numerous methods have been described for manufacture of methionine, including hydrolysis of methionine amide )and 5-(bmethylmercaptoethyl)- hydantoin.

Manufacturing Process

A 3-necked flask fitted with a stirrer, thermometer, gas inlet, dropping funnel, and brine-cooled reflux condenser was charged with 53 g (1.1 mol) methyl mercaptan and 0.35 g mercuric methyl mercaptide. After admitting 56 g (1.0mol) of acrolein during the course of 15 minutes with an inside temperature of about 10°C, the temperature was allowed to rise spontaneously to 75°C, at which point an ice bath was applied. There was no indication of further reaction one hour after the addition of the acrolein. Distillation of the product gave 71 g (yield 68%) of β-methylmercaptopropionaldehyde, as described in US Patent 2,584,496.
Then as described in US Patent 2,732,400, β-methylmercaptopropionaldehyde (0.60 M) (56.5 g) is added to a stirred solution of sodium cyanide (0.66 M) (32.4 g) and ammonium chloride (0.63 M) (33.7 g) in water (140 ml). The temperature of the mixture rises to 49°C and is maintained at this point by heat evolution for about 5 minutes when it slowly begins to fall. Methanol (50 ml) is added and the mixture is stirred for 4 hours as the temperature falls to 28°C (room temperature).
After chilling to +12°C, additional methanol (35 ml) and a concentrated aqueous ammoniun hydroxide solution (1.4 M) (100 ml) are added and stirring is continued for 2 hours at a temperature maintained at from +5° to +15°C. The organic layer is separated and solvent is stripped from the aqueous layer at water aspirator pressure at a temperature below 40°C. The residue is extracted several times with chloroform and the chloroform extracts are combined with the separated oil. Chloroform is removed at water aspirator pressure at a temperature below 35°C to leave crude α-amino-γmethylmercaptobutyronitrile (methionine nitrile) in 88% yield (68 g) as a clear, somewhat viscous oil.
The methionine nitrile (20 g) is dissolved in a solution prepared from 50 ml of aqueous 5 N sodium hydroxide solution and 65 ml of ethanol. The solution is then refluxed for 24 hours; ammonia is evolved. The solution is treated with activated carbon, filtered, acidified with glacial acetic acid (17 ml), chilled to - 10°C and filtered to give crude product. This crude product is then slurried with a solution made up of 20 ml of water and 20 ml of methanol, filtered at - 5° to +10°C and dried to give dl-methionine as white platelets.

Therapeutic Function

Lipotropic

Synthesis Reference(s)

Canadian Journal of Chemistry, 47, p. 3271, 1969 DOI: 10.1139/v69-542
Synthetic Communications, 26, p. 3619, 1996 DOI: 10.1080/00397919608003774

一般的な説明

Minute hexagonal plates from dilute alcohol.

空気と水の反応

Reacts with water, steam, and/or acids to produce toxic and flammable vapors of hydrogen sulfide . Water soluble . pH of 1% aqueous solution is 5.6-6.0.

反応プロフィール

An organosulfide and amine derivative, carboxylic acid. Look at Reactive Groups 20 (organosulfides), 7 (amines), and 3 (carboxylic acids) may give indications about reactive tendencies. L-Methionine is an amino acid essential in human nutrition.

健康ハザード

ACUTE/CHRONIC HAZARDS: L-Methionine is dangerous when heated to decomposition; it emits dangerous and highly toxic fumes.

火災危険

Flash point data for L-Methionine is not available, but L-Methionine is probably combustible.

応用例(製薬)

Methionine is used in oral pharmaceutical formulations as a flavoring agent.It has been included in parenteral formulations as a pH controlling agent,and it has also been used experimentally as an antioxidant with antibodies.Methionine is also used therapeutically in oral tablets

安全性プロファイル

Mildly toxic by ingestion and intraperitoneal routes. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. An essential sulfur-containing amino acid. When heated to decomposition it emits very toxic fumes of NOx and SOx.

安全性

Methionine is used in oral pharmaceutical formulations. The pure form of methionine is mildly toxic by ingestion and by the IP route.
LD50 (rat, IP): 4.328 g/k
LD50 (rat, oral): 36 g/kg

貯蔵

Methionine is sensitive to light and should be stored in a cool, dark place.

純化方法

Crystallise L-methionine from aqueous EtOH. Also purify it by dissolving ~0.5g of amino acid in ~10mL of hot H2O, filtering, adjusting the pH to 5.8 with 5N HCl, collecting the solid after addition of ~20mL of EtOH. It is recrystallised by dissolving in H2O and adding EtOH. It sublimes at 197-208o/0.3mm with 99.8% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Milne & Peng J Am Chem Soc 79 647 1957, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2125-2152 1961, Beilstein 4 IV 3189.]

不和合性

Methionine is incompatible with strong oxidizing agents.

規制状況(Regulatory Status)

Included in the FDA Inactive Ingredients Database (oral tablets). Included in parenteral preparations (injection solutions; powders for reconstitution) licensed in the UK.

L-メチオニン 上流と下流の製品情報

原材料

準備製品


L-メチオニン 生産企業

Global( 587)Suppliers
名前 電話番号 ファックス番号 電子メール 国籍 製品カタログ 優位度
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19932 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21734 58
Taizhou Tianhong Biochemistry Technology Co., Ltd.
0523-86132544
0523-86201489 sales@thbiochem.com CHINA 306 60
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22622 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 25016 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2799 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30025 58

63-68-3(L-メチオニン)キーワード:


  • 63-68-3
  • L-Met-OH
  • L-Methionine, Animal-Free
  • L-METHIONINE (13C5,D8,15N)
  • L-METHIONINE (1,2,3,4-13C4
  • METHYL-13CH3)
  • L-METHIONINE, REAGENT GRADE, >=98% (
  • L-MethionineUSP, 98.5-101.5% (Titration: anhydrous basis)
  • L(-)-Methionin
  • L-2-Amino-3-methylthiobuttersαure
  • lactet
  • L-alpha-Amino-gamma-methylmercaptobutyric acid
  • neo-methidin
  • s-methyl-l-homocystein
  • γ-methylthio-α-aminobutyricacid
  • 2-AMINO-4-METHYLMERCAPTOBUTYRIC ACID
  • METHIONINE, L-
  • METHIONINE
  • MET
  • L-BANTHIONINE
  • L-LOBAMINE
  • L-MET
  • (+)-L-METHIONINE
  • L-METHIONINE
  • L-2-AMINO-4-METHYLMERCAPTOBUTYRIC ACID
  • (S)-2-Amino-4-(methylmercapto)butyric acid, L-2-Amino-4-(methylthio)butanoic acid
  • L-Methionine Z
  • L-Methionine (H-Met-OH)
  • L-METHIONINERESEARCH GRADE
  • L-Methionine,(S)-2-Amino-4-(methylmercapto)butyric acid, L-2-Amino-4-(methylthio)butanoic acid
  • L-Methionine, extra pure
  • L-メチオニン
  • (S)-4-(メチルチオ)-2-アミノ酪酸
  • (S)-2-アミノ-4-(メチルチオ)ブタン酸
  • (-)-メチオニン
  • (S)-メチオニン
  • (-)-L-メチオニン
  • L-メチオニンZ
  • メチオニン
  • Lメチオニン
  • L‐メチオニン
  • L‐メチオニン CRM6023‐A
  • メチオニン, U.S.P.
  • メチオニン, L-
  • メチオニン, research grade, Ph. Eur.
  • L-メチオニン (JP17)
  • L-メチオニン 1
  • α-アミノ酸
  • アミノ酸
  • 生化学
  • 代謝産物
  • 解毒薬
  • 植物成長調整剤
Copyright 2017 © ChemicalBook. All rights reserved