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L-ロイシン

L-ロイシン 化学構造式
61-90-5
CAS番号.
61-90-5
化学名:
L-ロイシン
别名:
L-ロイシン;ロイシン;(S)-ロイシン;(S)-2-アミノ-4-メチル吉草酸;[S,(+)]-2-アミノ-4-メチル吉草酸;(S)-2-アミノ-4-メチルペンタン酸;(S)-4-メチル-2-アミノ吉草酸;(2S)-2-アミノ-4-メチルペンタン酸;(S)-4-メチル-2-アミノペンタン酸;L-2-アミノ-4-メチル吉草酸(L-ロイシン);L‐ロイシン;L‐ロイシン CRM6012‐A;Lイシン, L-;L-ロイシン, 細胞培養用, 結晶;L-(+)-ロイシン;L-ロイシン (JP17);ロイシン 1;ロイシン 2
英語化学名:
L-Leucine
英語别名:
LEU;L-LEU;Leucin;eucine;CH79091;LEUCINE;L-Leu-OH;H-LEU-OH;L-Leudne;1-Leucine
CBNumber:
CB8742186
化学式:
C6H13NO2
分子量:
131.17
MOL File:
61-90-5.mol

L-ロイシン 物理性質

融点 :
>300 °C (lit.)
沸点 :
122-134 °C(Press: 2-3 Torr)
比旋光度 :
15.4 º (c=4, 6N HCl)
比重(密度) :
1,293 g/cm3
蒸気圧:
<1 hPa (20 °C)
FEMA :
3297 | L-LEUCINE
屈折率 :
1.4630 (estimate)
闪点 :
145-148°C
貯蔵温度 :
2-8°C
溶解性:
1 M HCl: 50 mg/mL
外見 :
powder
酸解離定数(Pka):
2.328(at 25℃)
色:
White to Off-white
PH:
5.5-6.5 (20g/l, H2O, 20℃)
光学活性 (optical activity):
[α]20/D +15.5°, c = 2 in 6 M HCl
水溶解度 :
22.4 g/L (20 C)
極大吸収波長 (λmax):
λ: 260 nm Amax: 0.05
λ: 280 nm Amax: 0.05
JECFA Number:
1423
Sublimation :
145-148 ºC
Merck :
14,5451
BRN :
1721722
安定性::
Stability Moisture and light sensitive. Incompatible with strong oxidising agents.
CAS データベース:
61-90-5(CAS DataBase Reference)
NISTの化学物質情報:
Leucine(61-90-5)
EPAの化学物質情報:
L-Leucine (61-90-5)

安全性情報

Sフレーズ  24/25
WGK Germany  3
RTECS 番号 OH2850000
TSCA  Yes
HSコード  29224995
有毒物質データの 61-90-5(Hazardous Substances Data)
化審法 (9)-1632 届出不要化学物質

L-ロイシン 価格 もっと(63)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00012125 Lイシン, L-
Leucine, L-
61-90-5 100mg ¥16800 2020-09-21 購入
富士フイルム和光純薬株式会社(wako) W01CHDASB-00012125 Lイシン, L-
Leucine, L-
61-90-5 1g ¥33300 2018-12-26 購入
東京化成工業 L0029 L-ロイシン >99.0%(T)
L-Leucine >99.0%(T)
61-90-5 25g ¥1700 2021-03-23 購入
東京化成工業 L0029 L-ロイシン >99.0%(T)
L-Leucine >99.0%(T)
61-90-5 100g ¥5300 2021-03-23 購入
関東化学株式会社(KANTO) 24095-30 L‐ロイシン >99.0%(T)
L‐Leucine >99.0%(T)
61-90-5 25g ¥2600 2021-03-23 購入

L-ロイシン MSDS


L-Leu

L-ロイシン 化学特性,用途語,生産方法

外観

白色, 結晶~結晶性粉末

定義

本品は、次の化学式で表されるアミノ酸である。

溶解性

水にやや溶けにくく、エタノールに極めて溶けにくい。

解説

(S)-2-amino-4-methylpentanoic acid.C6H13NO2(131.17).略号LeuまたはL.必須α-アミノ酸の一つ.タンパク質構成アミノ酸として,また遊離の状態で広く自然界に分布している.グルテン,カゼイン,ケラチンなどの加水分解物から等電点沈殿法,イオン交換法によりイソロイシンとの混合物を得,2-ブロモトルエン-5-スルホン酸塩かナフタレン-2-スルホン酸塩として分離する.発酵法でもつくられる."光輝のある六方晶系.分解点293~295 ℃(封管中),昇華点145~148 ℃.[α]25D-10.8°(水).pK1 2.35,pK2 9.57(25 ℃).pI5.98.1日当たりの必要量は成人14 mg/kg,幼児161 mg/kg.DL-ロイシンはイソカプロン酸の臭素化,アミノ化やイソバレルアルデヒドのストレッカー反応で合成される.融点293~295 ℃.[CAS 61-90-5]
森北出版「化学辞典(第2版)

用途

製剤研究用。アミノ酸研究用。

化粧品の成分用途

ヘアコンディショニング剤、皮膚コンディショニング剤

効能

ロイシン補充薬

説明

Small, white, lustrous plates, or a white, crystalline powder, with a slightly bitter taste. One g dissolves in about 40 mL of water and in about 100 mL of acetic acid. It is sparingly soluble in alcohol, but is soluble in dilute hydrochloric acid and in solutions of alkali hydroxides and carbonates. ι-Leucine may be synthesized by bromination, followed by amination of isocaproic acid; via the acetamidomalonic ester; by isolation from gluten, casein, keratin; from hydantoin.

化学的特性

L-Leucine is odorless and has a slightly bitter taste. L-Leucine is a branched-chain, essential amino acid that stimulates muscle protein synthesis.

化学的特性

Leucine occurs as a white or almost off-white crystalline powder or shiny flakes.

化学的特性

White crystalline powder

天然物の起源

Reported found as a constituent in proteins; also present in the free state in the human body

使用

L-Leucine plays a vital role in hemoglobin formation, protein synthesis and metabolic functions. It assists the growth and repair of muscle and bone tissue. It is used in the treatment of amyotrophic lateral sclerosis - Lou Gehrig's disease. It prevents the breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. It is also used as a food additive and flavor enhancer. Further, it is used to preserve muscle glycogen.

使用

Amino acid.

製造方法

By bromination followed by amination of isocaproic acid; via the acetamidomalonic ester; by isolation from gluten, casein, keratin; from hydantoin.

調製方法

Leucine is produced microbially by incubating an amino-acidproducing microorganism including but not exclusive to Pseudomonas, Escherichia, Bacillus, or Staphylococcus in the presence of oxygen and a hydrocarbon. The nutrient medium should contain an inhibitory amount of a growth inhibitor that is a chemically similar derivative of leucine (e.g. methylallylglycine, a-hydrozinoisocaproic acid, or b-cyclopentanealanine) to inhibit the growth of the organism except for at least one mutant that is resistant to the inhibitory effect. The resistant mutant is then isolated and grown in the presence of oxygen and the hydrocarbon in the absence of the inhibitor. The mutant cells are then harvested and a nutrient medium is formed that includes a hydrocarbon as the sole source of carbon. Finally, the harvested cells are incubated in the medium in the presence of oxygen.

定義

ChEBI: The L-enantiomer of leucine.

一般的な説明

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com.

応用例(製薬)

Leucine is used in pharmaceutical formulations as a flavoring agent. It has been used experimentally as an antiadherent to improve the deagglomeration of disodium cromoglycate micro-particles and other compounds in inhalation preparations; and as a tablet lubricant. Leucine copolymers have been shown to successfully produce stable drug nanocrystals in water.

Biochem/physiol Actions

Leucine is a non-glucogenic, essential amino acid. It is a branched-chain amino acid that is a structural component of proteins. Leucine positively influences insulin release to eliminate toxic sugars out of the blood. The degradation of leucine leads to the formation of ketone bodies.

安全性

Leucine is an essential amino acid and is consumed as part of a normal diet. It is generally regarded as a nontoxic and nonirritant material. It is moderately toxic by the subcutaneous route.
LD50 (rat, IP): 5.379 g/kg

貯蔵

Leucine is sensitive to light and moisture, and should be stored in an airtight container in a cool, dark, dry place.

純化方法

Likely impurities are isoleucine, valine, and methionine. Crystallise L-leucine from water by adding 4 volumes of EtOH. It sublimes at 180-188o/0.3mm with 99.1% recovery, and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2075-2094 1961, Kameda et al. J Pharm Soc Jpn 78 763 1958, Beilstein 4 IV 2738.]

不和合性

Leucine is incompatible with strong oxidizing agents.

規制状況(Regulatory Status)

Included in the FDA Inactive Ingredients Database (IV infusion; oral tablets). Included in nonparenteral medicines licensed in the UK.

L-ロイシン 上流と下流の製品情報

原材料

準備製品


L-ロイシン 生産企業

Global( 710)Suppliers
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Capot Chemical Co.,Ltd.
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+86-571-85864795 sales@capotchem.com China 20012 60
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0371-55170693
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61-90-5(L-ロイシン)キーワード:


  • 61-90-5
  • (s)-2-amino-4-methylvalericacid
  • 1-Leucine
  • 2-Amino-4-methylpentanoic acid
  • 2-amino-4-methylpentanoicacid
  • 2-amino-4-methyl-valericaci
  • 4-methyl-l-norvalin
  • 4-methyl-norvalin
  • alpha-Amino-gamma-methylvaleric acid
  • alpha-amino-gamma-methylvalericacid
  • iso-C4H9CH(NH2)COOH
  • L(-)-Leucin
  • l-alpha-aminoisocaproicacid
  • Leucin
  • L-α-Amino-isocapronsαure
  • Norvaline, 4-methyl-
  • Pentanoic acid, 2-amino-4-methyl-
  • Pentanoic acid, 2-amino-4-methyl-, (S)-
  • pentanoicacid,2-amino-4-methyl-,(S)-
  • Valeric acid, 2-amino-4-methyl-
  • α-amino-γ-methylvalericacid
  • L-Leucine USP24
  • L-LEUCINE SIGMAULTRA
  • L-LEUCINE SOLUTION INSECT CELL CULTURE*T ESTED
  • L-Leucine, 99% (97+% EE/GLC)
  • L-LEUCINE, PH EUR
  • L-LEUCINE 98.5+% FCC
  • L-Leucine USP, Amino
  • L-Leucine>99.5%
  • L-LeucineForBiochemistry-(S)-2-Amino-4-MethylpentanoicAcid)
  • L-LeucineForBiochemistry
  • L-ロイシン
  • ロイシン
  • (S)-ロイシン
  • (S)-2-アミノ-4-メチル吉草酸
  • [S,(+)]-2-アミノ-4-メチル吉草酸
  • (S)-2-アミノ-4-メチルペンタン酸
  • (S)-4-メチル-2-アミノ吉草酸
  • (2S)-2-アミノ-4-メチルペンタン酸
  • (S)-4-メチル-2-アミノペンタン酸
  • L-2-アミノ-4-メチル吉草酸(L-ロイシン)
  • L‐ロイシン
  • L‐ロイシン CRM6012‐A
  • Lイシン, L-
  • L-ロイシン, 細胞培養用, 結晶
  • L-(+)-ロイシン
  • L-ロイシン (JP17)
  • ロイシン 1
  • ロイシン 2
  • α-アミノ酸
  • アミノ酸
  • 生化学
  • 必須アミノ酸
  • 代謝産物
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