L-메티오닌

L-메티오닌 속성

L-메티오닌 MSDS

L-Methionine

L-메티오닌 C화학적 특성, 용도, 생산

순도시험

  (1) 용상 : 이 품목 0.5g을 물 20mL에 녹일 때, 그 액은 무색으로서 그 탁도는 거의 징명 이하이어야 한다.

  (2) 액성 : 이 품목의 수용액(1→100)의 pH는  5.6～6.1이어야 한다.

  (3) 비선광도 : 이 품목은 4시간 건조한 다음 약 1g을 정밀히 달아 6N 염산에 녹여 50mL로 하고 이 액의 선광도를 측정할 때, ＝+21～+25°이어야한다.

  (4) 염화물 : 이 품목 2g을 물 100mL에 녹인 액 20mL에 묽은질산 6mL 를 가하여 이를 시험용액으로 하여 염화물시험법에 따라 시험할 때, 그 양은 0.01N 염산 0.4mL에 대응하는 양 이하이어야 한다.

  (5) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

  (6) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 5.0ppm 이하이어야 한다.

확인시험

  (1) 이 품목의 수용액(1→100)은 좌선성이나 이를 염산으로 산성으로 하면 우선성으로 변한다.

  (2) 이 품목의 수용액(1→1,000) 5mL에 닌히드린용액(1→1,000) 1mL를 가하고 3분간 가열할 때 자색을 나타낸다.

  (3) 이 품목 25mg을 무수황산동을 포화한 황산 1mL 에 가하면 황색을 나타낸다.

  (4) 이 품목의 수용액(1→100) 2mL에 수산화나트륨용액(1→25) 2mL를 가하여 잘 흔들어 섞고 니트로프루시드나트륨시액 0.3mL를 가하여 다시 잘 흔들어 섞은 다음 1～2분간 방치하고 이에 염산(1→10) 4mL를 가하여 잘 흔들어 섞으면 적자색을 나타낸다.

정량법

  「DL-메티오닌」의 정량법에 따라 정량한다.

강열잔류물

  이 품목의 강열잔류물은 0.1% 이하이어야 한다.

개요

Colorless or white lustrous plates, or a white crystalline powder. It has a slight, characteristic odor. It is soluble in water, in alkali solutions, and in dilute mineral acids. It is slightly soluble in alcohol and practically insoluble in ether.

화학적 성질

White crystalline powder

용도

L-Methionine is used as an essential amino acid for human development and therapeutically acts as an antidote for acetaminophen poisoning. It serves as a chelating agent for heavy metals, as a flavoring agent and nutritional supplement for foods. It acts as a feed additive, vegetable oil enrichment and as a single cell protein. In addition to this, it is used as a hepatoprotectant and also acts as a lipotropic agent and prevents excess fat buildup in the liver.

생산 방법

Numerous methods have been described for manufacture of methionine, including hydrolysis of methionine amide )and 5-(bmethylmercaptoethyl)- hydantoin.

정의

ChEBI: The L-enantiomer of methionine.

제조 방법

The production method of choice for L-methionine is still the enzymatic resolution of racemic N-acetyl-methionine using acylase from Aspergillus oryzae.  The production is carried out in a  continuously operated fixed-bed or enzyme  membrane reactor.

일반 설명

Minute hexagonal plates from dilute alcohol.

공기와 물의 반응

Reacts with water, steam, and/or acids to produce toxic and flammable vapors of hydrogen sulfide . Water soluble . pH of 1% aqueous solution is 5.6-6.0.

반응 프로필

An organosulfide and amine derivative, carboxylic acid. Look at Reactive Groups 20 (organosulfides), 7 (amines), and 3 (carboxylic acids) may give indications about reactive tendencies. L-Methionine is an amino acid essential in human nutrition.

건강위험

ACUTE/CHRONIC HAZARDS: L-Methionine is dangerous when heated to decomposition; it emits dangerous and highly toxic fumes.

화재위험

Flash point data for L-Methionine is not available, but L-Methionine is probably combustible.

Pharmaceutical Applications

Methionine is used in oral pharmaceutical formulations as a flavoring agent.It has been included in parenteral formulations as a pH controlling agent,and it has also been used experimentally as an antioxidant with antibodies.Methionine is also used therapeutically in oral tablets

Safety Profile

Mildly toxic by ingestion and intraperitoneal routes. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. An essential sulfur-containing amino acid. When heated to decomposition it emits very toxic fumes of NOx and SOx.

Safety

Methionine is used in oral pharmaceutical formulations. The pure form of methionine is mildly toxic by ingestion and by the IP route.
LD₅₀ (rat, IP): 4.328 g/k
LD₅₀ (rat, oral): 36 g/kg

저장

Methionine is sensitive to light and should be stored in a cool, dark place.

Purification Methods

Crystallise L-methionine from aqueous EtOH. Also purify it by dissolving ~0.5g of amino acid in ~10mL of hot H2O, filtering, adjusting the pH to 5.8 with 5N HCl, collecting the solid after addition of ~20mL of EtOH. It is recrystallised by dissolving in H2O and adding EtOH. It sublimes at 197-208o/0.3mm with 99.8% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Milne & Peng J Am Chem Soc 79 647 1957, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2125-2152 1961, Beilstein 4 IV 3189.]

비 호환성

Methionine is incompatible with strong oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral tablets). Included in parenteral preparations (injection solutions; powders for reconstitution) licensed in the UK.

L-메티오닌 준비 용품 및 원자재

원자재

준비 용품

L-메티오닌 공급 업체

공급자	전화	이메일	국가	제품 수	이점
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9365	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	958	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	2991	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15932	58
Taizhou Tianhong Biochemistry Technology Co., Ltd.	0523-86132544	sales@thbiochem.com	CHINA	305	60
Shanghai Bojing Chemical Co.,Ltd.	+86-86-02137122233 +8613795318958	bj1@bj-chem.com	China	298	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55

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