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Methylphenidate hydrochloride

Methylphenidate hydrochloride 구조식 이미지
카스 번호:
298-59-9
상품명:
Methylphenidate hydrochloride
동의어(영문):
Equasym;Concerta;Metadate;Centedin;Centedrin;Centedrine;NSC 169868;Ciba 4311b;Metadate CD;METHYLPHENIDATE HCL
CBNumber:
CB0188559
분자식:
C14H20ClNO2
포뮬러 무게:
269.77
MOL 파일:
298-59-9.mol

Methylphenidate hydrochloride 속성

녹는점
196-198?C
인화점
9℃
저장 조건
Store at RT
용해도
Freely soluble in water, soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
산도 계수 (pKa)
8.9(at 25℃)
안정성
Stable. Combustible. Incompatible with strong oxidizing agents, alkalies, barbiturates.
CAS 데이터베이스
298-59-9(CAS DataBase Reference)
EPA
2-Piperidineacetic acid, .alpha.-phenyl-, methyl ester, hydrochloride(298-59-9)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,T,F
위험 카페고리 넘버 22-42-39/23/24/25-23/24/25-11
안전지침서 22-26-36-45-36/37-16
유엔번호(UN No.) 3249
WGK 독일 3
RTECS 번호 TM3850000
위험 등급 6.1(b)
포장분류 III
독성 LD50 orally in mice: 190 mg/kg (Greenblatt, Osterberg)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H334 흡입 시 알레르기성 반응, 천식 또는 호흡 곤란 등을 일으킬 수 있음 호흡기 과민성 물질 구분 1 위험 P261, P285, P304+P341, P342+P311,P501
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P311 의료기관(의사)의 진찰을 받으시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P342+P311 호흡기 증상이 나타나면 의료기관(의사)의 진찰을 받으시오.

Methylphenidate hydrochloride C화학적 특성, 용도, 생산

화학적 성질

white crystalline powder

용도

antiinflammatory

용도

Controlled substance (stimulant). CNS stimulant. Four isomers of Methylphenidate are known to exist. One pair of threo isomers and one pair of erythro are distinguished, from which only d-threo-Methyl phenidate exhibits the pharmacologically usually desired effects.

용도

Methylphenidate (a.k.a., Ritalin) is a schedule II drug in the United States commonly used as a psychostimulant for the treatment of attention-deficit hyperactivity disorder. It blocks dopamine and norepinephrine transporters as well as facilitates NMDA-receptor mediated synaptic transmission through σ1 receptors via PLC/PKC signaling. This interaction with the σ1 receptor has been suggested to underlie methylphenidate’s considerable abuse potential and potential psychiatric side effects. This product is intended for forensic and biological research applications.[Cayman Chemical]

일반 설명

Because methylphenidate (Ritalin) has two asymmetriccenters, there are four possible isomers. The threo racemateis the marketed compound and is about 400 times aspotent as the erythro racemate.The absolute configurationof each of the threo-methylphenidate isomers has beendetermined.Considering that the structure is fairly complex(relative to amphetamine), it is likely that one of thetwo components of the threo racemate contains most of theactivity. Evidence indicates that the (+) -(2R,2'R)threoisomer is involved principally in the behavioral andpressor effects of the racemate.As is likely with many central psychomotor stimulants, there are multiple modesof action.
Methylphenidate, probably largely via its p-hydroxymetabolite, blocks NE reuptake, acts as a postsynapticagonist, depletes the same NE pools as reserpine, and haseffects on dopaminergic systems, such as blocking DAreuptake.
Methylphenidate is a potent CNS stimulant. Indicationsinclude narcolepsy and attention-deficit disorder.

일반 설명

Odorless white crystalline powder. Metallic taste. Solutions are acid to litmus. Absence of general acid/base catalysis.

공기와 물의 반응

Water soluble.

반응 프로필

Methylphenidate hydrochloride is incompatible with alkalis and solutions of barbiturates . Undergoes typical ester hydrolysis in aqueous solutions at 176°F.

화재위험

Flash point data for Methylphenidate hydrochloride are not available; however, Methylphenidate hydrochloride is probably combustible.

생물학적 활성

Psychomotor stimulant. Inhibitor of dopamine and noradrenalin transporters that increases the extracellular concentration of dopamine and noradrenalin. Increases locomotor activity in vivo .

Veterinary Drugs and Treatments

Methylphenidate may be useful for treating cataplexy/narcolepsy or hyperactivity in dogs.

Methylphenidate hydrochloride 준비 용품 및 원자재

원자재

준비 용품


Methylphenidate hydrochloride 공급 업체

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Shanghai Meishui Chemical Technology Co., Ltd 021-60549325 18616193163
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