Moxifloxacin
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Moxifloxacin 속성
- 녹는점
- 203-208 C
- 알파
- 23D -193°
- 끓는 점
- 636.4±55.0 °C(Predicted)
- 밀도
- 1.408±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C(protect from light)
- 용해도
- 아세토니트릴 (약간 용해됨), DMSO(약간 용해됨,가열, 초음파 처리), 메탄올 (약간 용해됨)
- 산도 계수 (pKa)
- 6.43±0.50(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 황백색에서 밝은 노란색까지
- 안정성
- 흡습성
- CAS 데이터베이스
- 151096-09-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
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위험 카페고리 넘버 | 22-40 | ||
안전지침서 | 36/37 | ||
유해 물질 데이터 | 151096-09-2(Hazardous Substances Data) |
그림문자(GHS): | |||||||||||||||||||||||||||||
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신호 어: | Warning | ||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Moxifloxacin C화학적 특성, 용도, 생산
용도
Moxifloxacin is an antibiotic for the treatment of bacterial infections like bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.정의
ChEBI: A quinolone that consits of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b /ital>]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.Antimicrobial activity
It displays good activity in vitro against Enterobacteriaceae and fastidious Gram-negative bacilli such as H. influenzae and Mor. catarrhalis, as well as against Grampositive cocci including Str. pneumoniae, but is poorly active against Enterococcus spp. Activity against non-fermentative Gramnegative bacilli is species dependent: Acinetobacter spp. (MIC 0.006–2.0 mg/L) and Sten. maltophilia (MIC 0.5–2.0 mg/L) are partially susceptible in vitro, but it has poor activity against Ps. aeruginosa and other non-fermenting Gram-negative rods. It displays good in-vitro activity against Ch. pneumoniae, C. trachomatis, mycoplasmas (including M. pneumoniae), L. pneumophila and B. fragilis. Although highly active against M. tuberculosis, it is less active against the M. avium complex, M. intracellulare, M. chelonei and M. fortuitum.Pharmaceutical Applications
fluoroquinolone substituted with an 8-methoxy group and a 7-diazabicyclononyl moiety, formulated as the hydrochloride for oral or intravenous use.Pharmacokinetics
absorption and distributionBy the oral route, drug uptake is rapid, with moderate variability. As with all quinolones iron and antacids significantly reduce the bioavailability. No significant drug interactions with theophylline, itraconazole, probenecid or oral contraceptives have been found. In escalating dose studies (50–80 mg doses), Cmax and AUC values increased proportionally to the dose.
It is widely distributed throughout the body and into many tissues in concentrations exceeding those in plasma. Around 50–80% of plasma concentrations penetrate into CSF if the meninges are inflamed. The apparent plasma half-life is 15.6 h.
Metabolism and excretion
Biliary elimination and metabolism are the main elimination pathways. About 19.3% of the administered dose is eliminated in the urine, with a bioavailability of 86.2%. Urinary excretion is via glomerular filtration and tubular reabsorption. Two main metabolites are recovered: M1 (a sulfocompound) and M2 (a glucuronide). M1 is mainly eliminated in feces (34.4%) and only 2.5% in urine: M2 is eliminated in urine (13.8%).
Clinical Use
Acute bacterial exacerbations of chronic bronchitis and communityacquired pneumonia
Acute bacterial sinusitis
Treatment of complicated skin and soft-tissue infections caused by methicillin-susceptible Staph. aureus and Gram-negative rods (i.v. formulation)
Treatment of complicated intra-abdominal infections (i.v. formulation)
부작용
Adverse events are similar to those for other fluoroquinolones. Phototoxicity rates are not significantly above placebo levels. Gastrointestinal side effects are the most common, particularly nausea, diarrhea, abdominal pain and vomiting. Dizziness and headache may occur as well as allergic reactions. Attention has been drawn to a potential to cause lifethreatening hepatotoxicity. Moxifloxacin has the potential to prolong the QTc interval in some patients but the clinical significance of this phenomenon is unclear.Moxifloxacin 준비 용품 및 원자재
원자재
노르말옥탄
QUINOLINE-3-CARBOXYLIC ACID
Clotrimazole
무수초산
DIETHYLSTILBESTROLMONOMETHYLETHER
Pyridine-2-3-DicarboxylicAcid-N-Benzylimide
황산
PYRIDINE 2
ETHYLENE GLYCOL
시안화 제I구리
마그네슘에틸레이트
염화제2철6수화물
Palladium hydroxide
염화 티오닐
시클로프로필아민
오소포름산에틸
불화소다
P-톨루엔설폰 산
말론산 디에틸
수산화칼륨
중탄산나트륨(중조)
아세트산(빙초산)
준비 용품
Moxifloxacin 공급 업체
글로벌( 321)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 967 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Wuhan Chemwonders Technology Inc. | 027-85778276 |
info@chemwonders.com | CHINA | 176 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
Moxifloxacin 관련 검색:
노르말노난 프로필티오우라실 1,8-디아자비사이클로[5.4.0]운덴센-7 수소 질소 플루오린(불소)
Clinafloxacin
Sparfloxacin
Gemifioxacin
Gatifloxacin
TROVAFLOXACIN
MOXIFLOXACIN HCL,MOXIFLOXACIN HYDROCHLORIDE
MOXIFLOXACIN, HYDROCHLORIDE MONOHYDRATE
QUINOLINE-3-CARBOXYLIC ACID
MOXIFLOXACIN
rac cis Moxifloxacin-D4, Hydrochloride
Moxifloxacin Acyl-b-D-glucuronide
Moxifloxacin Acyl Sulfate