Chlormidazole
|
|
Chlormidazole 속성
- 녹는점
- 67.5°C
- 끓는 점
- bp12 240-242°
- 밀도
- 1.1578 (rough estimate)
- 굴절률
- 1.5749 (estimate)
- 산도 계수 (pKa)
- 5.41±0.10(Predicted)
안전
Chlormidazole C화학적 특성, 용도, 생산
Originator
Diamyceline,DiamantManufacturing Process
The first method synthesis of 1-p-chlorobenzyl-2-methylbenzimidazole: 26.4 g of 2-methylbenzimidazole are dissolved in 350 ml of dioxane, 10 g of sodium amide are added there to. After about 5 min 41,2 g of pchlorobenzylbromide are added to the resulting mixture which is then boiled under reflux for 6 hours. Dioxane is removed by distillation. The residue is triturated with dilute hydrochloric acid. The resulting crystalline mass representing the crude hydrochloride of 1-p-chlorobenzyl-2- methylbenzimidazole is filtered off by suction and recrystallized from water. On cooling, colorless crystals are obtained which are dissolved in hot water. Dilute ammonia solution is added to the resulting aqueous solution to render it weakly alkaline. The base of 1-p-chloro-benzyl-2-methylbenzimidazole precipitates, first in liquid form, and gradually solidifies to a white mass of its hydrate. After recyrstallization from aqueous ethanol, the product has a melting point of 67-68°C. The base of 1-p-chlorobenzyl-2- methylbenzimidazole distills in the form of a colorless oil at 240-242°C/12 mm. Its hydrate of the melting point 67-68°C is obtained by trituration with water.The second method of synthesis of 1-p-chlorobenzyl-2-methylbenzimidazole:
23.3 g of p-chlorobenzyl-o-phenylenediamine are boiled under reflux with 75 ml of glacial acetic acid for 3 hours. Most of the acetic acid is then removed by distillation. Dilute sodium hydroxide solution is added to the residue to render it weakly alkaline. The resulting base of 1-p-chlorobenzyl-2- methylbenzunidazole is purified as such by recrystallization from aqueous ethanol. It may also be converted into its hydrochloride which is then worked up as described hereinabove in the first method of synthesis.
Therapeutic Function
AntifungalChlormidazole 준비 용품 및 원자재
원자재
4-Chlorobenzyl bromide
나트륨아미드
2-Methylbenzimidazole
아세트산(빙초산)
Benzenemethanamine, 4-chloro-N-(2-nitrophenyl)-
N-(2-Acetylphenyl)-4-methylbenzene-1-sulfonamide
1H-Benzimidazole, 2-methyl-1-[(4-methylphenyl)sulfonyl]-
N-(p-chlorobenzyl)aniline
에틸알코올
클로로(4-)벤질아민
2-니트로아닐린
O-플루오로니트로벤젠
준비 용품
Chlormidazole 공급 업체
글로벌( 24)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52867 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50000 | 58 |
| China Langchem Inc. | 0086-21-58956006 |
China | 7815 | 57 | |
| Chengdu Research Accelerators Technology Co., Ltd. | 028-64353063 |
reacchemical@163.com | China | 5259 | 58 |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 |
sales@tcisct.com | China | 31183 | 58 |
| Shaanxi Xihua Chemical Industry Co., Ltd | 17691182729 15529505138 |
1021@dideu.com | China | 10011 | 58 |