3-Indolepropionic acid
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3-Indolepropionic acid 속성
- 녹는점
- ~133 °C
- 끓는 점
- 82 °C(lit.)
- 밀도
- 0.960 g/mL at 20 °C
- 증기 밀도
- 2.1 (vs air)
- 증기압
- 33 mm Hg ( 20 °C)
- 굴절률
- n
20/D 1.377(lit.)
- 인화점
- 53 °F
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 에탄올: 용해성50mg/mL, 투명, 노란색~주황색
- 산도 계수 (pKa)
- 4.77±0.10(Predicted)
- 물리적 상태
- 수정 같은
- 색상
- 연노랑
- 수용성
- 약간 용해됨
- BRN
- 147733
- CAS 데이터베이스
- 830-96-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22-36/37/38 | ||
| 안전지침서 | 26-37/39 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | NM1329000 | ||
| F 고인화성물질 | 8-10-23 | ||
| TSCA | Yes | ||
| HS 번호 | 29339990 | ||
| 독성 | LDLo intraperitoneal in mouse: 100mg/kg |
3-Indolepropionic acid C화학적 특성, 용도, 생산
개요
Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities. It scavenges ABTS radicals in a cell-free assay when used at concentrations ranging from 50 to 150 μM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC50 = 180 μM). Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells. It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; ) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day.화학적 성질
pale yellow to yellow crystalline powder용도
3-Indolepropionic acid is a deamination product of Tryptophan (T947200) that protects the hippocampus (studied in gerbils) from ischemic damage and oxidative stress. It’s ability to protect the neurons in this way is attributed to its potent antioxidative effects. 3-Indolepropionic acid is also hypothesized to have protective effects on the thyroid gland.정의
ChEBI: An indol-3-yl carboxylic acid that is propionic acid substituted by a 1H-indol-3-yl group at position 3.일반 설명
3-Indolepropionic acid is an effective inhibitor of aggregation of misfolded β-amyloid protein (Abeta). Three-component one-pot procedure has been reported to assemble 3-indolepropionic acids.Purification Methods
Recrystallise it from EtOH/water [James & Ware J Phys Chem 89 5450 1985]. The picrate has m 143-144o, and the methyl ester crystallises from *C6H6 or MeOH with m 81-83o. [Beilstein 22 III/IV 1113, 22/3 V 114.]3-Indolepropionic acid 준비 용품 및 원자재
원자재
Ethyl 2-oxocyclopentanecarboxylate
디카복실산, C4-6
weak
Indole-2-carboxylic acid
phenylhydrazone
1H-Indole-3-propanoic acid, 1-(2,2-dimethyl-1-oxopropyl)-
2-(1H-indol-3-yl)butanedioic acid
1H-Indole-3-propanoic acid, β-oxo-
Diethyl 2-(1H-indol-3-ylmethyl)propanedioate
Propanedioic acid,2-(1H-indol-3-ylmethyl)-
3-(2-carboxyindol-3-yl)propionic acid
1H-Indole-3-propanoicacid, cyclohexyl ester
1H-Indole-3-acetic acid, .alpha.-Methyl-
DONAXINE iodomethylate
3-(2-BROMOETHYL)INDOLE
5-Bromoindole
준비 용품
3-Indolepropionic acid 공급 업체
글로벌( 681)공급 업체
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| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
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| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
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| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
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linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8823 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |