L-트립토판

L-트립토판 속성

L-트립토판 MSDS

Indole-3-alanine

L-트립토판 C화학적 특성, 용도, 생산

화학 반응

L 트립토판은 식물에 있는 옥신 생합성의 중요한 precusor 물질입니다. 그것에는 IAA의 유사한 구조가 있습니다. 그것은 더 높은 식물에서 넓게 존재합니다. 합성 옥신에 2가지의 방법이 있습니다. 첫번째 트립토판 산화하고 deaminize 형성합니다 인돌 아세톤, 그 후에 카르복시 이탈과 모양 IAAId를입니다; 대응 효소의 밑에 IAAId는 인돌초산 산을 oxsidizes. 두번째 방법은 카르복시 이탈이고 tryptamine 그 때 tryptamine에 모양은 탈아미노반응을 마지막으로 형성합니다 트립토판을 oxsidize.

개요

L- 트립토판의 다른 이름 인 2- 아미노 -3- (1H- 인돌 -3- 일) 프로판 산은 인체가 만들 수 없기 때문에 필수 아미노산이라고 불립니다. 음식에서 얻어야합니다. L- 트립토판은 세로토닌, 멜라토닌 및 키 누레 닌을 생산하는 아미노산입니다. L- 트립토판 보충제는 우울증, 불안 및 불면증으로 도움을줍니다.

용도

L- 트립토판은 우울증에 사용되는 아미노산입니다. 그것은 또한 incomnia, 수면 무호흡증, 불안, 얼굴 통증, 월 경전 증후군의 가혹한 모양을 위해 이용 될지도 모른다.

순도시험

  (1) 용상 : 이 품목 0.5g을 0.5N 수산화나트륨용액 10mL에 녹일 때, 그 색은 비색표준용액 C보다 진하여서는 아니 된다. 또한 그 탁도는 거의 징명 이하이어야 한다.

  (2) 액성 : 이 품목의 수용액(1→100)의 pH는 5.5～7.0이어야 한다.

  (3) 비선광도 : 이 품목을 105℃에서 3시간 건조한 다음, 약 0.5g을 정밀히 달아 물 40mL를 가하여 가열하여 녹이고 식힌 다음 물을 가하여 50mL로 하여 이 액의 선광도를 측정할 때, ＝-30～-33°이어야 한다.

  (4) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.

  (5) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 5.0ppm 이하이어야 한다.

  (6) 염화물 : 「DL-트립토판」의 순도시험 (5)에 따라 시험한다.

확인시험

  (1) 이 품목의 수용액(1→50)은 좌선성이나 이에 수산화나트륨용액(1→5)을 가하여 알칼리성으로 하면 우선성으로 변한다.

  (2) 「DL-트립토판」의 확인시험 (2) 및 (3)에 따라 시험한다.

정량법

  이 품목을 건조한 다음 약 0.3g을 정밀히 달아 빙초산 50mL를 가하여 가열하여 녹이고 식힌 다음 0.1N 과염소산용액으로 적정한다(지시약 : α-나프톨벤제인시액 10방울). 종말점은 액의 갈색이 녹색으로 변하는 점으로 한다.

0.1N 과염소산용액 1mL ＝ 20.42mg C₁₁H₁₂O₂N₂

강열잔류물

강열잔류물  이 품목 1g을 취하여 강열잔류물시험법에 따라 시험할 때, 그 양은 0.1% 이하이어야 한다.

화학적 성질

Appearance: white crystalline powder. Odorless, slightly bitter taste;
Solubility: slightly soluble in water (1.14%, 25 ℃), insoluble in ethanol; soluble in dilute acid or dilute alkali. mp 289 ° C (decomposition).
Isoelectric point: 5.89. [α] D + 2.8 (5 mol / L HCl), [α] D + 6.2 (0.5 mol / L NaOH).
It can be colored upon long-term exposure to light. Its co-heating reaction with water will generate a small amount of indole while heating in the presence of sodium hydroxide and copper sulfate will produce a large amount of indole. It is stable upon heating together with acid in the dark, but is easily to be decomposed when heated together with other amino acids, carbohydrates and aldehydes. L-tryptophan will be completely decomposed when applying acid to break down the protein.

용도

L-tryptophan is an essential amino acid which is necessary for normal growth in infants and for nitrogen balance in adults. It acts as a natural dietary supplement and used as an antidepressant, anxiolytic and sleep aid. It is used as a precursor to niacin, indole alkaloids and serotonin. It acts as an important intrinsic fluorescent probe, which finds to estimate the nature of microenvironment of the tryptophan.

정의

ChEBI: The L-enantiomer of tryptophan.

생산 방법

The most attractive production processes for tryptophan are based on microorganisms used as enzyme sources or as overproducers: Enzymatic production from various precursors; Fermentative production from precursors; Direct fermentative production from carbohydrates by auxotrophic and analogue resistant regulatory mutants. L-tryptophan is synthesized from indole, pyruvate, and ammonia by the enzyme tryptophanase or from indole and L-serine/D,L-serine by tryptophan synthase these process variants were not economic due to the high costs of the starting materials. The microbial conversion of biosynthetic intermediates such as indole or anthranilic acid to L-tryptophan has also been considered as alternative for production.
However, the manufacturer using genetically modified strains derived fromBacillus amyloliquefaciens IAM 1521 was forced to stop Ltryptophan production. L-Tryptophan produced by this process was stigmatized because of side products found in the product causing a new severe disease termed eosinophilia-myalgia syndrome (EMS). One of the problematic impurities, "Peak E", was identified as 1,10-ethylidene- bis-(L-tryptophan), a product formed by condensation of one molecule acetaldehyde with two molecules of tryptophan.

World Health Organization (WHO)

L-tryptophan, an essential aminoacid and precursor of serotonin, was introduced into medicine in 1963 for the treatment of depression and sleep disorders. Its effectiveness in these conditions has, however, never been convincingly demonstrated. It is also widely used in dietary supplements, parenteral nutrition preparations and dietary products for children with phenylketonuria. In 1989, reports from the USA showed an association between the consumption of L-tryptophan containing preparations and the development of eosiniphilia-myalgia syndrome (EMS), a condition characterized by intense eosinophilia, severe muscle and joint pain, swelling of the arms and legs, skin rashes and possible fever. Some of the reported cases have been fatal. Since it is not yet clear whether L-tryptophan itself or an unidentified contaminant is the cause of the EMS, many drug regulatory authorities have suspended the marketing authorization of products containing tryptophan pending further investigation, whereas others have withdrawn these products or restricted their use.

일반 설명

White powder with a flat taste. An essential amino acid; occurs in isomeric forms.

공기와 물의 반응

Slightly soluble in water.

반응 프로필

Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

건강위험

ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Tryptophan emits toxic fumes.

화재위험

Flash point data for L-Tryptophan are not available. L-Tryptophan is probably combustible.

Safety Profile

Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise L-tryptophan from H2O/EtOH, wash it with anhydrous diethyl ether and dry it at room temperature in a vacuum over P2O5. It sublimes at 220-230o/0.03mm with 99% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Cox & King Org Synth Coll Vol II 612 1943, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2316-2345 1961, Beilstein 22 IV 6765.]

L-트립토판 준비 용품 및 원자재

원자재

준비 용품

L-트립토판 공급 업체

공급자	전화	이메일	국가	제품 수	이점
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9365	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	sarah@tnjone.com	China	893	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
Wuhan Han Sheng New Material Technology Co.，Ltd	+8617798174412	admin01@hsnm.com.cn	China	2118	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Across Biotech Jinan Co LTD	+8613031735486	frank@acrossbiotech.com	China	105	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
Shandong Juchuang Chemical Co., LTD	+86-18885615001 +86-18885615001	admin@juchuangchem.com	China	387	58

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