2-메틸인돌린
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2-메틸인돌린 속성
- 녹는점
- 57-59 °C (lit.)
- 끓는 점
- 273 °C (lit.)
- 밀도
- 1,07 g/cm3
- 굴절률
- 1.6070 (estimate)
- 인화점
- 141 °C
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- 클로로포름(소량으로 용해), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- 17.57±0.30(Predicted)
- 물리적 상태
- 결정체, 플레이크 또는 결정성 분말
- 색상
- 노란색에서 붉은 보라색 또는 갈색
- 냄새
- 디프로필렌 글리콜 중 0.10%. 배설물 냄새가 없는 스카톨보다 더 신선한 동물성 인돌
- ?? ??
- 동물
- 수용성
- 물에 불용성.
- 감도
- Light Sensitive
- BRN
- 109781
- InChIKey
- BHNHHSOHWZKFOX-UHFFFAOYSA-N
- LogP
- 2.530
- CAS 데이터베이스
- 95-20-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 20/21/22-41 | ||
| 안전지침서 | 36/37-24/25-39-26 | ||
| 유엔번호(UN No.) | 3335 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | NM0345000 | ||
| F 고인화성물질 | 8-10-13-23 | ||
| TSCA | Yes | ||
| HS 번호 | 29339990 |
2-메틸인돌린 C화학적 특성, 용도, 생산
화학적 성질
Colorless needle or yellow to reddish-purple or brown crystals, flakes. Has an animal type odor.Soluble in ethanol and ether, insoluble in water.용도
2-Methylindole is an intermediate in the synthesis of indole derivative with potential antifungal activities. It can be used as a raw material for the preparation of deacetylase (HDAC) inhibitor panobinostat.제조 방법
2-Methylindole was synthesized from 2-Acetamidotoluene by the following procedure. 2-Acetamidotoluene was added to the mixture of anhydrous ether and sodium amide, heated to 240-260°C under the protection of nitrogen flow, kept for 10min, a large amount of gas was generated in the reaction, and the reaction ended when the gas stopped escaping, and cooled. Ethanol and warm water were added and heated to decompose the sodium derivative of 2-Methylindole and excess sodium amide. After cooling, it was extracted with ether. The extract was concentrated and then distilled, and the fractions at 119-126°C (0.4-0.53kPa) were collected to obtain 2-Methylindole with a yield of 80%-83%. The product can be purified by methanol recrystallization.정의
ChEBI: 2-Methylindole is a methylindole that is 1H-indole substituted by a methyl group at position 2. It derives from a hydride of a 1H-indole.주요 응용
2-Methylindole is used as a reactant Reactant for:Regioselective synthesis of oxopyrrolidine analogs via iodine-catalyzed Markovnikov addition reaction
Friedel-Crafts alkylation reactions
Preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
Preparation of plant-growth inhibitors
Michael addition reactions
Synthesis of cyclooxygenase-1 (COX-1)/cyclooxygenase-2 (COX-2) inhibitors
Purification Methods
Crystallise it from *benzene. It has also been purified by zone melting. The picrate has m 139o (from Et2O or Et2O/MeOH). [Cohen et al. J Am Chem Soc 82 2184 1960, Beilstein 20 III/IV 3202, 20/7 V 59.]2-메틸인돌린 준비 용품 및 원자재
원자재
2-Acetamidotoluene
디에틸에테르
나트륨아미드
Benzene, 1-nitro-2-(1-propen-1-yl)-
2-METHYL-1H-INDOLE-3-CARBOXYLIC ACID
1-(2-nitrophenyl)propan-2-one
Benzenamine, 2-(2-propenyl)-
준비 용품
2-메틸인돌린 공급 업체
글로벌( 441)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7845 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 |
info@longyupharma.com | China | 2531 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 |
sales@alchempharmtech.com | United States | 63711 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 |
sales@chemwish.com | CHINA | 10828 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 |
ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |