트라이엠시놀론
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트라이엠시놀론 속성
- 녹는점
- 262-263 °C(lit.)
- 끓는 점
- 587.5±50.0 °C(Predicted)
- 알파
- 69 º (c=2, DMF)
- 밀도
- 1.1703 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMF: 가용성20mg/mL
- 산도 계수 (pKa)
- 11.57±0.70(Predicted)
- 물리적 상태
- Solid
- 색상
- 크리스탈
- optical activity
- [α]25/D +69°, c = 2 in DMF
- 수용성
- 79.99mg/L(25℃)
- Merck
- 9595
- InChIKey
- GFNANZIMVAIWHM-OBYCQNJPSA-N
- CAS 데이터베이스
- 124-94-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
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위험 카페고리 넘버 | 40 | ||
안전지침서 | 22-36 | ||
WGK 독일 | 3 | ||
RTECS 번호 | TU3850000 | ||
HS 번호 | 2937220000 | ||
유해 물질 데이터 | 124-94-7(Hazardous Substances Data) | ||
독성 | LD50 subcutaneous in mouse: > 4gm/kg |
그림문자(GHS): | |||||||||||||||
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신호 어: | Warning | ||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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트라이엠시놀론 C화학적 특성, 용도, 생산
개요
A natural extension of corticoid research involved examination of compounds containing both a 9α-fluoro group and a double bond between positions 1 and 2. Triamcinolone (9-fluoro-11β, 16α, 17, 21-tetrahydroxypregna- 1,4-diene-3,20-dione), introduced in 1958, combines the structural features of a ?1 -corticoid and a 9α-fluoro corticoid. As mentioned previously, the 9α-fluoro group increases the anti-inflammatory potency, but it also markedly increases the mineralocorticoid potency. This is undesirable if the drug is to be used internally for the treatment of rheumatoid arthritis. By inserting a 16α-hydroxy group into the molecule, one can decrease the mineralocorticoid activity.화학적 성질
White, crystalline powder. Insoluble in water; slightly soluble in usual organic solvents; soluble in dimethylformamide.용도
Triamcinolone is a glucocorticoid. Triamcinolone is used as an antiasthmatic (inhalant); antiallergic (nasal).정의
ChEBI: A C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9. sed in the form of its 16,17-acetonide to treat various skin infections.Indications
Intralesional bleomycin, a cytotoxic drug that inhibits DNA synthesis, is effective for all varieties of recalcitrant warts. Various concentrations of the drug have been used, although the total dose must be carefully tracked over time to avoid potential systemic toxicity.Clinical Use
Triamcinolone to be used topically is generally dispensed as its more potent and lipophilic acetonide, a 16α,17α-methylenedioxy cyclic ketal or isopropylidene derivative. It is effective in the treatment of psoriasis and other corticoid-sensitive dermatologic conditions. Topically, triamcinolone acetonide is a more potent derivative of triamcinolone and is approximately eight times more active than prednisolone.부작용
Even though triamcinolone has an apparently decreased tendency to cause salt and water retention and edema and may induce sodium and water diuresis, it causes other unwanted side effects, including anorexia, weight loss, muscle weakness, leg cramps, nausea, dizziness, and a general toxic feeling.Safety Profile
Poison by subcutaneous route.An experimental teratogen. Other experimentalreproductive effects. Human mutation data reported.When heated to decomposition it emits toxic fumes of F??.An anti-inflammatory and antiallergic agent.트라이엠시놀론 준비 용품 및 원자재
원자재
Triamcinolone diacetate
soy broth
수산화칼륨
판쿠로늄 브롬화물
Pregna-1,4-diene-3,20-dione, 11β,16α,17,21-tetrahydroxy-, 16,21-diacetate
Triamcinolone 21-acetate
Budesonide Impurity 18
준비 용품
트라이엠시놀론 공급 업체
글로벌( 274)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 |
overseasales1@yongstandards.com | United States | 14335 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
트라이엠시놀론 관련 검색:
4-히드록시벤즈알데히드 메틸파라벤 트리클로산 글리콜산 4-메톡시페놀 4-하이드록시벤조 산( 플루오린(불소) 프레드니손 프레드니솔원
TRIAMCINOLONE HEXACETONIDE,Triamcinolone hexatonide
Hydroxy silicone oil
10-Hydroxycamptothecin
HYDROXYAPATITE TYPE I
TRIAMCINOLONE ACETONIDE,Triamcinolone 16,17-acetonide,triamcinolone16,17-acetonid
Triamcinolone hexacetonide for system
suitability
TRIAMCINOLONE IMPURITY C
Fluocinonide
ciprocinonide