Gonadorelin acetate
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Gonadorelin acetate 속성
- 녹는점
- >155oC (dec.)
- 저장 조건
- Hygroscopic, Refrigerator, Under inert atmosphere
- 용해도
- 메탄올(약간 용해됨), 물(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
- 안정성
- 흡습성
- InChIKey
- NGCGMRBZPXEPOZ-NWVXUHCVNA-N
- CAS 데이터베이스
- 34973-08-5
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
그림문자(GHS): | |||||||||||||||||||||||
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신호 어: | Danger | ||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Gonadorelin acetate C화학적 특성, 용도, 생산
개요
Gonadorelin Acetate is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis.Gonadorelin, also known as GnRH or LHRH, is produced by neuroendocrine cells within the hypothalamus. The hormone is secreted pulsatilely. Gonadorelin induces the release of LH and FSH from the anterior pituitary.
After a transient increase, continuous administration of gonadorelin results in downregulation of LH and FSH levels followed by a suppression of ovarian and testicular steroid biosynthesis.
용도
Gonadorelin Acetate is used in various agricultural and biological studies. It was used in the study of ovulation synchronization in dairy cows.주요 응용
Ovarian follicular cysts (veterinary medicine)Use in reproduction medicine
Diagnosis of the hypothalamic-pituitary-gonadal axis function
Cryptorchism
Synchronization of ovulation (veterinary medicine)
Indications
Gonadorelin is a synthetic decapeptide with a structure identical with the natural Gonadotrophin Releasing Hormone (Gn-RH) in mammalian species.Gonadorelin is recommended for the treatment of reproductive disorders associated with ovarian cysts and for improvement of fertility in cows and for the induction of ovulation in rabbits. The mechanism of action underlying the therapeutic use is the stimulation of the release from and also the synthesis of LH and FSH in the anterior pituitary gland.
생물학적 활성
Gonadorelin is a tropic hormone and agonist of the gonadotropin-releasing hormone receptor (GNRHR; Ki = 13 nM in CHO cells expressing the human receptor). It stimulates luteinizing hormone (LH) and follicle- stimulating hormone (FSH) release from rat anterior pituitary cultures when administered at a dose of 0.1 μg. It also stimulates LH release from bovine anterior pituitary cultures at a concentration of 1 μM. In vivo, gonadorelin induces ovulation in rats pretreated with fluphenazine (Item No. 23555; ED50 = 610.3 ng/kg). Formulations containing gonadorelin have been used as diagnostic agents to assess pituitary gland function.부작용
Gonadorelin side effects: headache; flushing; nausea or abdominal discomfort; dizziness or lightheadedness; pain, swelling, or itching at the injection site; or. skin rash.Safety Profile
A poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits acrid smoke and irritating vapors.Gonadorelin acetate 준비 용품 및 원자재
원자재
준비 용품
Gonadorelin acetate 공급 업체
글로벌( 188)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Strong peptide cross-border e-commerce Co. LTD | +undefined13930052870 |
qt01@qiangtaipharm.com | China | 84 | 58 |
Cellmano Biotech Limited | 0551-65326643 18156095617 |
info@cellmano.com | China | 999 | 58 |
Zhejiang Hangyu API Co., Ltd | +8617531972939 |
anna@api-made.com | China | 2944 | 58 |
Qingdao Xinli Technology Development Co., Ltd. | +8616632313095 |
xinlikeji01@qdxlchem.com | China | 135 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 973 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Shanghai Yunao International Trade Co., Ltd | +8617621705551 |
asdf@shanghaihg.cn | China | 265 | 58 |
Wuhan Han Sheng New Material Technology Co.,Ltd | +8617798174412 |
admin01@hsnm.com.cn | China | 2118 | 58 |
Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 |
xinshengkeji@xsmaterial.com | China | 1090 | 58 |
zhuzhou dingcheng meihei comestic co.,ltd | +8618873369619 |
dingchengbusiness8@163.com | China | 260 | 58 |