피루브산
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피루브산 속성
- 녹는점
- 11-12 °C (lit.)
- 끓는 점
- 165 °C (lit.)
- 밀도
- 1.267 g/mL at 25 °C (lit.)
- 증기압
- 1.72hPa at 25℃
- FEMA
- 2970 | PYRUVIC ACID
- 굴절률
- n
20/D 1.428(lit.)
- 인화점
- 183 °F
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름 및 메탄올과 혼합 가능.
- 산도 계수 (pKa)
- 2.39(at 25℃)
- 물리적 상태
- 액체
- 색상
- 무색~담황색 또는 호박색으로
- 수소이온지수(pH)
- 3.11(1 mM solution);2.38(10 mM solution);1.79(100 mM solution);
- 냄새
- 프로필렌 글리콜 중 1.00%. 날카로운 신맛의 아세트 캐러멜
- ?? ??
- 산성의
- 생물학적 소스
- synthetic
- 수용성
- H2O: miscible
alcohol: miscible
diethyl ether: miscible
- Merck
- 14,8021
- JECFA Number
- 936
- BRN
- 506211
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제, 강한 염기와 호환되지 않습니다. 냉장보관하세요.
- InChIKey
- LCTONWCANYUPML-UHFFFAOYSA-N
- LogP
- -1.24
- 해리상수
- 2.49 at 25℃
- CAS 데이터베이스
- 127-17-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | C | ||
---|---|---|---|
위험 카페고리 넘버 | 34 | ||
안전지침서 | 26-36/37/39-45-25-27 | ||
유엔번호(UN No.) | UN 3265 8/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | UZ0829800 | ||
자연 발화 온도 | 305 °C | ||
TSCA | Yes | ||
위험 등급 | 8 | ||
포장분류 | II | ||
HS 번호 | 29335995 | ||
기존화학 물질 | KE-27649 |
피루브산 C화학적 특성, 용도, 생산
화학적 성질
Pyruvic acid has a sour, acetic odor (similar to acetic acid). It has a pleasant, sour taste with a burning, somewhat sweet note. It tends to darken and decompose unless kept free of minor contaminants and in tightly sealed containers출처
Isolated from cane sugar fermentation broth and from a few plants; also reported found in peppermint, raw asparagus, leaves and stalk of celery, onion, rutabaga, milk, cream, buttermilk, wheaten bread, blue cheeses, cheddar cheese, cottage cheese, provolone cheese, yogurt, beef, Virginia tobacco, beer, white wine, botrytised wine, cocoa and sake.용도
pyruvic acid is an alpha hydroxy acid that can be irritating and is considered difficult to work with. It has a larger molecular size than the most commonly used AHAs. Sodium pyruvate is more commonly used, and is an organic salt.제조 방법
By distillation of tartaric acid in the presence of potassium acid sulfate as a dehydrating agent; from acetyl chloride and potassium cyanide to yield the nitrile, which is subsequently acid hydrolyzed to the acid; pyruvic acid must be rectified under vacuum.정의
Pyruvic acid is an important organic chemical intermediate, an intermediate compound in the metabolism of carbohydrates, proteins, and fats, and is used in a variety of fields, including the pharmaceutical, cosmetic, food, and chemical industries. It has roles as a basic metabolite and cofactor. In thiamine deficiency, its oxidation is retarded and it tends to accumulate in neurostructural tissues causing neurological damage. In vitro studies have shown that pyruvic acid modulates cardiac function at physiological or low doses, but can cause cardiomyocyte damage at high doses.일반 설명
Pyruvic acid is the key component formed during the hydrolysis of flavor-precursors called S-alk(en)yl-L-cysteine-sulfoxides in onion tissues by allinase during maceration or chopping. The amount of pyruvic acid formed is used as a measure for onion pungency.Biotechnological Applications
Pyruvic acid is a key position in cell metabolism and is involved in many catabolic and anabolic pathways, including glycolysis, gluconeogenesis, amino acid, and protein metabolism. Pyruvic acid is employed for the production of L-tryptophan, L-tyrosine, and 3,4-dihydroxyphenyl alanine in various industries. The diet supplementation with pyruvic acid increased fat loss and minimized the associated loss of body protein. Pyruvic acid is also used in biochemical researches and medicine as a substrate for assaying activities of such enzymes as pyruvate dehydrogenase, pyruvate carboxylase, and pyruvate decarboxylase (Nakazawa et al. 1972; Yamada et al. 1972; Stanko et al. 1992).Y. lipolytica oxidize glucose and form pyruvic acid (75–80 %) and a-ketoglutaric acid (20–25 %) under thiamine deficiency conditions. The synthesis of the acid was triggered by a decrease in intracellular thiamine concentration to 3.0 lg per 1 g biomass. An approximately 3-fold increase in the amount of the biomass was associated with a subsequent decrease in thiamine content to the level of 1.0 lg per 1 g biomass, whose maximum production of pyruvic acid was 50 g/L in this condition. In addition to glucose, thiamine-auxotrophic yeasts are capable of synthesizing pyruvic acid when grown on glycerol and propionic acid. Technicalgrade glycerol is the most promising raw material for pyruvic acid production. Pyruvic acid was obtained at a concentration of 61 g/L with a yield of 71 % from glycerol (Morgunov et al. 2004; Finogenova et al. 2005).
Synthesis
Pyruvic acid's synthesis method is as follows: from Tartaric acid by heating with hydrophilic agents, such as Potassium hydrosulfate.Purification Methods
Distil it twice, then fractionally crystallise it by partial freezing. [Beilstein 3 IV 1505.]피루브산 준비 용품 및 원자재
원자재
메틸 글리옥살
알드린
유리황산 칼륨
Glass-lined reaction pot
에틸 피루브산
과산화 수소
이산화 망간
피루브 산, 나트륨 염
D-(-)-젖 산
산소, 냉각된 액체
DL-타타르산
유산에틸
이산화탄소
D(-)-Tartaric acid
6-벤질아미노퓨린
Dehydrolyzing agent
달라폰
유산
프로필렌 글리콜
Catalyst CR
니켈오르토인산염
황산 칼륨
사이안화 칼륨
황산칼륨
준비 용품
3-Bromopyruvic acid
1,2,3-티아디아졸-4-카르복실산
Acetylpyrazine
티아벤다졸
에틸(R)-2-하이드록시-4-페닐부티레이트
3-메르캅토프로피온산
carfentrazone-ethyl
Gestrinone
에틸 피루브산
6-아자티민
1,2,3-Thiadiazole-4-carbonyl chloride (6CI,7CI,8CI,9CI)
피루브 산, 나트륨 염
Calcium pyruvate
4-티아졸 카르복실산
DL-트립토판
SULFENTRAZONE
3-메틸-2-퀴녹살리놀
2-아미노-3-메틸퀴녹살린
피루브산메틸
2-클로로-3-메틸-퀴녹살린
피루브산 공급 업체
글로벌( 622)공급 업체
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