메틸프레드니솔론
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메틸프레드니솔론 속성
- 녹는점
- 228-237°C (dec.)
- 알파
- D20 +83° (dioxane)
- 끓는 점
- 423.47°C (rough estimate)
- 밀도
- 1.0868 (rough estimate)
- 굴절률
- 82 ° (C=1, Dioxane)
- 저장 조건
- 0-6°C
- 용해도
- 에 용해됨 클로로포름/메탄올(9:1): 50mg/mL, 투명, 희미한 노란색
- 산도 계수 (pKa)
- 12.46±0.70(Predicted)
- 색상
- 흰색에서 황백색까지
- 수용성
- 0.12g/L(25℃)
- Merck
- 14,6111
- BRN
- 2340300
- BCS Class
- 2 or 4?
- InChIKey
- VHRSUDSXCMQTMA-PJHHCJLFSA-N
- CAS 데이터베이스
- 83-43-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 22-36-26 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | TU4146000 | ||
| F 고인화성물질 | 8-10-23 | ||
| HS 번호 | 2937290000 | ||
| 유해 물질 데이터 | 83-43-2(Hazardous Substances Data) |
| 그림문자(GHS): |
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| 신호 어: | Danger | ||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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메틸프레드니솔론 C화학적 특성, 용도, 생산
화학적 성질
White to Off-White Crystalline Powder정의
ChEBI: The 6alpha-stereoisomer of 6-methylprednisolone.일반 설명
Methylprednisolone, 11β,17,21-trihydroxy-6α-methyl-1,4-pregnadiene-3,20-dione, isavailable unmodified or as ester derivatives.Methylprednisolone acetate, USP
Methylprednisolone sodium succinate, USP.
Mechanism of action
Methylprednisolone is an analog of prednisolone that exhibits a more prolonged effect than prednisolone and cortisone; it has practically no mineralocorticosteroid activity and is better tolerated.Clinical Use
Adding a 6α-methyl group to prednisolone increases the glucocorticoid activity and effectively abolishes mineralocorticoid action. It has fivefold the glucocorticoid activity of hydrocortisone (prednisolone has fourfold the glucocorticoid activity) and none of its mineralocorticoid properties. It is used almost exclusively as a systemic product and is available as the free alcohol for oral administration and as various esters.Safety Profile
Moderately toxic by intraperitoneal route. A steroid hormone. Human systemic effects include arrhythmias, blood pressure lowering, heart rate changes, increased body temperature, pulse rate increase, respiratory depression. When heated to decomposition it emits acrid smoke and irritating fumes.Purification Methods
Recrystallise medrol from EtOAc. The UV has max at in 95% EtOH 243nm ( 14,875). The 21-acetoxy derivative has m 205-208o (from EtOAc), and [] D +95o ( c 1, CHCl3). [Spero et al. J Am Chem Soc 78 6213 1956; Fried et al. J Am Chem Soc 81 1235 1959; 1H NMR: Slomp & McGarvey J Am Chem Soc 81 2200 1959, Beilstein 8 IV 3498.]메틸프레드니솔론 준비 용품 및 원자재
원자재
준비 용품
메틸프레드니솔론 공급 업체
글로벌( 380)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 |
nova@sh-teruiop.com | China | 525 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hubei XinRunde Chemical Co., Ltd. | +8615102730682 |
bruce@xrdchem.cn | CHINA | 566 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 |
sales@czwytech.com | CHINA | 906 | 58 |