눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P308+P313
노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P312
불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.
P321
(…) 처치를 하시오.
P330
입을 씻어내시오.
P332+P313
피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
P362
오염된 의복을 벗고 세척 후에 재사용하기
P370+P378
화재 시 불을 끄기 위해 (Section 5. 폭발, 화재시 대처방법의 적절한 소화제)을(를) 사용하시오.
P405
밀봉하여 저장하시오.
P501
...에 내용물 / 용기를 폐기 하시오.
Metoprolol C화학적 특성, 용도, 생산
용도
Metoprolol is a β-adrenergic blocking antihypertensive and antianginal agent; to treat raised blood pressure; to prevent attacks of angina (pain
from an inadequate oxygen supply to the heart); after a heart attack to prevent further damage to the heart muscle; treatment of some
disturbances of heart rhythm; used to help prevent attacks of migraine; in ophthalmic preparations; treatment of myocardial infarcts.
Mechanism of action
Unlike propranolol, which blocks both β1 and β2-adrenoreceptors, metroprolol exhibits
cardioselective action, i.e. in therapeutic doses, it blocks β1-adrenoreceptors with insignificant
effects on β2-adrenoreceptors.
신진 대사
The pharmacokinetic profile of metoprolol (Lopressor)
is similar to that of propranolol. Metoprolol is readily
and rapidly absorbed after oral administration and is
subject to a significant amount of first-pass metabolism
by the liver. Curiously, the duration of metoprolol’s action
is longer than one would predict from its plasma
half-life, which ranges from 0.5 to 2.5 hours. The degree
of binding of metoprolol to plasma proteins is modest
(10%). The extensive distribution of metoprolol to the
lungs and kidney is typical of a moderately lipophilic
drug. Metoprolol undergoes considerable metabolism;only 3 to 10% of an administered dose is recovered as
unchanged drug.The metabolites are essentially inactive
as -receptor blocking agents and are eliminated primarily
by renal excretion. Small amounts of the drug are
present in the feces.
