시메티딘
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시메티딘 속성
- 녹는점
- 139-144°C
- 끓는 점
- 476.2±55.0 °C(Predicted)
- 밀도
- 1.2583 (rough estimate)
- 굴절률
- 1.5700 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 물에 약간 용해되고, 에탄올(96%)에 용해되며, 염화메틸렌에는 거의 용해되지 않습니다. 묽은 무기산에 용해됩니다.
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- pKa 6.80 (Uncertain)
- 색상
- 흰색에서 황백색까지
- 수용성
- 20°C에서 0.5g/100mL
- Merck
- 14,2279
- InChIKey
- AQIXAKUUQRKLND-UHFFFAOYSA-N
- CAS 데이터베이스
- 51481-61-9(CAS DataBase Reference)
- IARC
- 3 (Vol. 50) 1990
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 60-42/43-36/37/38-20/22 | ||
안전지침서 | 53-26-36/37/39-45-36-22 | ||
WGK 독일 | 3 | ||
RTECS 번호 | MF0035500 | ||
HS 번호 | 29339900 | ||
유해 물질 데이터 | 51481-61-9(Hazardous Substances Data) | ||
독성 | LD50 in mice, rats (mg/kg): 2600, 5000 orally; 150, 106 i.v.; 470, 650 i.p. (Brimblecombe) |
시메티딘 C화학적 특성, 용도, 생산
개요
Cimetidine is a representative of first-generation antihistamine drugs that block H2 receptors.화학적 성질
White Solid용도
Cimetidine is used for treating ulcer problems of the stomach and duodenum and for other conditions accompanied by an elevation of acidity and excess secretion of gastric juice. It is used for preventing injuries and the blood flow of the upper regions of the gastrointestinal tract.정의
ChEBI: A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H -receptor antagonist that inhibits the production of acid in stomach.Indications
Cimetidine, the first released H2-blocker, like histamine, contains an imidazole ring structure. It is well absorbed following oral administration, with peak blood levels 45 to 90 minutes after drug ingestion. Blood levels remain within therapeutic concentrations for approximately 4 hours after a 300-mg dose. Following oral administration, 50 to 75% of the parent compound is excreted unchanged in the urine; the rest appears primarily as the sulfoxide metabolite.일반 설명
White crystals with a slight sulfur-mercaptan odor.공기와 물의 반응
Slightly water soluble.화재위험
Flash point data for Cimetidine are not available. Cimetidine is probably combustible.생물학적 활성
Widely used H 2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I 1 imidazoline binding site ligand.Pharmacology
The main pharmacological effect of cimetidine is the suppression of gastric juice secretion associated with H2 receptors of the stomach walls. It suppresses both basal and stimulated hydrochloric acid produced by food as well as histamine and gastrine, which simultaneously lower pepsin activity.부작용
Cimetidine may infrequently cause diarrhea, nausea, vomiting, or mental confusion. A rare association with granulocytopenia, thrombocytopenia, and pancytopenia has been reported. Gynecomastia has been demonstrated in patients receiving either high-dose or long-term therapy.시메티딘 준비 용품 및 원자재
원자재
준비 용품
시메티딘 공급 업체
글로벌( 626)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Wuhan Qiami Technology Co., Ltd | +8618062705058 |
qiamichem@163.com | China | 148 | 58 |
Shanghai Medfine Bio-pharmaceutical Co., Ltd | +8619921460217 |
tina.lv@bio-medfine.com | China | 203 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 |
1022@dideu.com | China | 3878 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5872 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Sigma Audley | +86-15937194204 +86-18126314766 |
nova@sh-teruiop.com | China | 491 | 58 |
Hangzhou Hyper Chemicals Limited | +86-0086-57187702781 +8613675893055 |
info@hyper-chem.com | China | 295 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1143 | 58 |
Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 +86-18239973690 |
sales@suikangpharm.com | China | 311 | 58 |
시메티딘 관련 검색:
티오초산 티오판산-메틸 벤설프론 메틸 쿠레톡심메틸 메틸파라벤 티오황산 나트륨 펜타수화물 싸이오아세트아마이드 2-티오바르비투르 산 에틸 시아노아크릴산 아크릴산메틸 메틸 파라싸이온(메틸 파라티온) 브롬화 메틸 시메티딘
Sitagliptin
Methyl
S,S-DIMETHYL-N-CYANODITHIOIMINO CARBONATE [DIMETHYL-N-CYANOTHIOCARBONATE]CIMETIDINE
N-Cyano-N-[2-(5-methylimidazole-4-methylthio)ethyl]-S-methyl isothiourea
(5-Ethyl-1H-imidazol-4-yl)methanol