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Gemcitabine

Gemcitabine 구조식 이미지
카스 번호:
95058-81-4
상품명:
Gemcitabine
동의어(영문):
Zefei;Gemcel;GemLip;LY-18011;Folfugem;NSC 613327;GeMcitabin;GeMictabine;Gamcitabine;GEMCITABINE
CBNumber:
CB4438054
분자식:
C9H11F2N3O4
포뮬러 무게:
263.2
MOL 파일:
95058-81-4.mol

Gemcitabine 속성

녹는점
168,64 C
알파
365 +425.36°; D +71.51°
CAS 데이터베이스
95058-81-4(CAS DataBase Reference)

안전

위험품 표기 Xn,Xi
위험 카페고리 넘버 21-36/38-46-62-63
안전지침서 25-26-36/37-53
HS 번호 29349990
유해 물질 데이터 95058-81-4(Hazardous Substances Data)
독성 LD10 i.v. in rats: 200 mg/m2 (Abbruzzese)

Gemcitabine C화학적 특성, 용도, 생산

용도

Gemcitabine(Gemzar) belongs to the group of medicines called antimetabolites. It is used alone or in combination with other medicines to treat cancer of the breast, ovary, pancreas, and lung. Gemcitabine interferes with the growth of cancer cells, which a

Indications

Gemcitabine (Gemzar), an antimetabolite, undergoes metabolic activation to difluorodeoxycytidine triphosphate, which interferes with DNA synthesis and repair. It is the single most active agent for the treatment of metastatic pancreatic cancer, and it is used as a first-line treatment for both pancreatic and small cell lung cancer. It is administered by intravenous infusion. The dose-limiting toxicity is bone marrow suppression.

일반 설명

The drug is available as the hydrochloride salt in 200- and1,000-mg lyophilized single-dose vials for IV use.Gemcitabine is used to treat bladder cancer, breast cancer,pancreatic cancer, and NSCLC. Gemcitabine is a potent radiosensitizer,and it increases the cytotoxicity of cisplatin.The mechanism of action of this fluorine-substituted deoxycytidineanalog involves inhibition of DNA synthesis andfunction via DNA chain termination. The triphosphatemetabolite is incorporated into DNA inhibiting severalDNA polymerases and incorporated into RNA inhibitingproper function of mRNA. Resistance can occur because ofdecreased expression of the activation enzyme deoxycytidinekinase or decreased drug transport as well as increasedexpression of catabolic enzymes. Drug oral bioavailabilityis low because of deamination within the GI tract, and thedrug does not cross the blood-brain barrier. Metabolism bydeamination to 2', 2'-difluorouridine (dFdU) is extensive.Drug toxicity includes myelosuppression, fever, malaise,chills, headache, myalgias, nausea, and vomiting.

위험도

Human systemic effects

Gemcitabine 준비 용품 및 원자재

원자재

준비 용품


Gemcitabine 공급 업체

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Lianyungang happen teng technology co., LTD
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Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
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Capot Chemical Co.,Ltd.
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Shenzhen Sendi Biotechnology Co.Ltd.
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Henan DaKen Chemical CO.,LTD.
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Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60

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