P-크레졸
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P-크레졸 속성
- 녹는점
- 32-34 °C(lit.)
- 끓는 점
- 202 °C(lit.)
- 밀도
- 1.034 g/mL at 25 °C(lit.)
- 증기 밀도
- 3.72 (vs air)
- 증기압
- 1 mm Hg ( 20 °C)
- FEMA
- 2337 | P-CRESOL
- 굴절률
- nD20 1.5395
- 인화점
- 193 °F
- 저장 조건
- Store below +30°C.
- 용해도
- 20g/L
- 산도 계수 (pKa)
- 10.17(at 25℃)
- 물리적 상태
- 결정질 고체 또는 액체
- 색상
- 무색~연황색, 빛에 노출되면 어두워질 수 있음
- Specific Gravity
- 1.0341 (20/4℃)
- 냄새
- 디프로필렌 글리콜 중 0.10%. 페놀 수선화 동물 미모사
- ?? ??
- 페놀성
- Odor Threshold
- 0.000054ppm
- 폭발한계
- 1%(V)
- 수용성
- 20g/L(20℃)
- 감도
- Light Sensitive
- JECFA Number
- 693
- Merck
- 14,2579
- BRN
- 1305151
- Henry's Law Constant
- 6.17 at 20.00 °C, 9.31 at 25.00 °C (dynamic equilibrium system-GC, Feigenbrugel et al., 2004a)
- 노출 한도
- NIOSH REL: TWA 2.3 ppm (10 mg/m3), IDLH 250 ppm; OSHA PEL: TWA 5 ppm (22 mg/m3); ACGIH TLV: TWA for all isomers 5 ppm (adopted).
- Dielectric constant
- 5.6(21.0℃)
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다. 공기와 빛에 민감합니다. 흡습성.
- LogP
- 1.94
- CAS 데이터베이스
- 106-44-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 24/25-34-39/23/24/25-23/24/25 | ||
안전지침서 | 36/37/39-45-36/37 | ||
유엔번호(UN No.) | UN 3455 6.1/PG 2 | ||
OEB | B | ||
OEL | TWA: 2.3 ppm (10 mg/m3) | ||
WGK 독일 | 1 | ||
RTECS 번호 | GO6475000 | ||
F 고인화성물질 | 8 | ||
자연 발화 온도 | 555 °C | ||
위험 참고 사항 | Irritant | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | II | ||
HS 번호 | 29071200 | ||
유해 물질 데이터 | 106-44-5(Hazardous Substances Data) | ||
독성 | LD50 orally in rats: 1.8 g/kg (Deichmann, Witherup) | ||
기존화학 물질 | KE-24794 | ||
유해화학물질 필터링 | 97-1-268 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 크레졸 및 이를 5% 이상 함유한 혼합물 |
P-크레졸 C화학적 특성, 용도, 생산
물성
무색 황색을 띠는 투명한 액체.용도
P- 크레졸,흰색 또는 무색 결정. 알코올에 용해, 에테르, 클로로포름 및 온수에. 주요 용도: 의학, 살충제, 향수, 합성 수지 및 염료, 등.화학적 성질
Cresol is a mixture of three isomeric forms: o-, m-, and p-cresol. These compounds are slightly soluble in water. The m-isomer is a colorless or yellow liquid with characteristic odor. The p-cresol is a colorless to pink crystals with a characteristics phenol-like odor. The concentration at which the odor becomes detectable in water is 55 parts per billion (Buttery et al., 1988). Another study by Leonardos et al. (1969) reported an experimental odor threshold concentration of 1 parts per billion, which is higher than the 0.054 parts per billion reported by Nagata and Takeuchi (1990).출처
Has been found in a score of essential oils including ylang ylang and oil of jasmine (Gildemeister & Hoffman, 1966).용도
p-Cresol is utilized in the production of artificial resins, liquid crystal intermediates, disinfectants, fumigants, and as an industrial solvent. It is also involved in the manufacturing of Bupranolol, a non-selective beta blocker.정의
ChEBI: P-cresol is a cresol that consists of toluene substituted by a hydroxy group at position 4. It is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals. It has a role as a uremic toxin, a human metabolite and an Escherichia coli metabolite.생산 방법
The cresols (cresylic acids) are methyl phenols and generally appear as a mixture of isomers. p-Cresol is a 4-methyl derivative of phenol and is prepared from m-toluic acid or obtained from coal tar or petroleum. Crude cresol is obtained by distilling “gray phenic acid” at a temperature of ~180–201°C. p-Cresol may be separated from the crude or purified mixture by repeated fractional distillation in vacuo. It can also be prepared synthetically by diazotization of the specific toluene or by fusion of the corresponding toluenesulfonic acid with sodium hydroxide.제조 방법
It can be prepared by fractional distillation of coal tar where it occurs together with the ortho- and para- isomers.일반 설명
Colorless solid with a tar like odor. Sinks and mixes slowly with water.공기와 물의 반응
Insoluble in water.반응 프로필
p-Cresol is sensitive to heat. p-Cresol is also sensitive to light. p-Cresol is incompatible with strong oxidizers and strong alkalis. p-Cresol will attack some forms of plastics, coatings and rubber.건강위험
INHALATION: Irritation of nose or throat. EYES: Intense irritation and pain, swelling of conjunctiva and corneal damage may occur. SKIN: Intense burning, loss of feeling, white discoloration and softening. Gangrene may occur. INGESTION: Burning sensation in mouth and esophagus. Vomiting may result. Absorption by all routes may cause muscular weakness, gastroenteric disturbance, severe depression and collapse. Effects are primarily on central nervous system, edema of lungs, injury of spleen and pancreas may occur.Safety Profile
Poison by ingestion, skin contact, subcutaneous, intravenous, and intraperitoneal routes. A severe skin and eye irritant. Questionable carcinogen with experimental neoplastigenic data by itself and with 7,12-dirnethyl benz(a)anthracene. Combustible when exposed to heat or flame. Moderately explosive in the form ofvapor when exposed to heat or flame. To fight fire, use CO2, dry chemical, alcohol foam. See also other cresol entries and PHENOL.잠재적 노출
Cresol is used as a disinfectant and fumigant; as an ore flotation agent, and as an intermediate in the manufacture of chemicals, dyes, plastics, and antioxidants. A mixture of isomers is generally used; the concentrations of the components are determined by the source of the cresol.Carcinogenicity
o-Cresol has been induced a few papillomas but no carcinomas in tumor studies.신진 대사
p-Cresol is oxidized at the methyl group in both dogs and rabbits to yield ρ-hydroxybenzoic acid. In the rabbit up to 10% of oral doses of 0.25-0.5 g is excreted as free and conjugated p-hydroxybenzoic acid (Williams, 1959).운송 방법
UN2076 Cresols, liquid, Hazard class: 6.1; Labels: 6.1-Poisonous materials, 8-Corrosive material. UN3455 Cresols, solid, Hazard class: 6.1; Labels: 6.1- Poisonous materials, 8-Corrosive material.Purification Methods
It can be separated from m-cresol by fractional crystalisation of its melt. Purify it by distillation, by precipitation from *benzene solution with pet ether, and via its benzoate, as for phenol. Dry it under vacuum over P2O5. It has also been crystallised from pet ether (b 40-60o) and by conversion to sodium p-cresoxyacetate which, after crystallisation from water is decomposed by heating with HCl in an autoclave [Savard Ann Chim (Paris) 11 287 1929]. The 3,5-dinitrobenzoate (prepared with 3,5-dinitrobenzoyl chloride in dry pyridine, and recrystallised from EtOH or aqueous Me2CO) has m 189o. [Beilstein 6 II 2093.]비 호환성
Vapors may form explosive mixture with air. Incompatible with strong acids; oxidizers, alkalies, aliphatic amines; amides, chlorosulfonic acid; oleum. Decomposes on heating, producing strong acids and bases, causing fire and explosion hazard. Liquid attacks some plastics and rubber. Attacks many metals.폐기물 처리
Wastewaters may be subjected to biological treatment. Concentrations may be further reduced by ozone treatment. High concentration wastes may be destroyed in special waste incinerators.P-크레졸 준비 용품 및 원자재
원자재
톨루엔술폰산소다
m-cresol and p-cresol mixture
P-톨루엔설폰 산
나프톨 AS-올
PHENOLPHTHALIN
O-크레졸
크레졸
아질산 나트륨
2-METHYLANILINE SULFATE
m-크레졸
준비 용품
p-Tolyl phenylacetate
4-메틸아니솔
톨터로딘
2,2-Dimethyl-3-(2-methylpropyl)cyclopropanecarboxylic acid p-(methoxymethyl)benzyl ester
아세트산파라토릴에스테르
2-Bromo-4-methylphenol
3,5-DIMETHYL-BENZOFURAN-2-CARBOXYLIC ACID
2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol
2-[[4-[[4-[bis(2-hydroxyethyl)amino]-6-chloro-1,3,5-triazin-2-yl]amino]phenyl]azo]-p-cresol
Mn(Ⅲ)salen epoxidation catalyst
ETHYL 4-ETHOXYPHENYLACETATE
2-tert-Butyl-4-methylphenol
4-CHLOROMETHYL-6-METHYL-CHROMEN-2-ONE
4-히드록시벤즈알데히드
Ethyl 3,5-dimethylbenzofuran-2-carboxylate ,95%
P-TOLYL ISOBUTYRATE
1-(2-Hydroxy-5-methylphenyl)ethanone
아니스알데히드
m-크레졸
산성오렌지116
부틸산화 히드록시톨루엔
2-히드록시-5-메틸-1,3-벤젠디카르복스알데히드
Neutral Brown Rl
P-크레졸 공급 업체
글로벌( 515)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Guanlang Biotechnology Co., Ltd. | +8619930503259 |
cherry@crovellbio.com | China | 18420 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5882 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 |
info@tnjchem.com | China | 2989 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |