메프로바메이트 C화학적 특성, 용도, 생산
화학적 성질
white crystalline powder
용도
An anxiolytic.
This is a controlled substance.
World Health Organization (WHO)
Meprobamate, a bis-carbamate ester, was introduced in 1955 for
the treatment of anxiety and was subsequently used as a sedative-hypnotic drug.
Psychological and physical dependence can occur and abuse has been reported.
Meprobamate is controlled under Schedule IV of the 1971 Convention on
Psychotropic Substances.
(Reference: (UNCPS4) United Nations Convention on Psychotropic Substances (IV),
, , 1971)
일반 설명
Meprobamate,2-methyl-2-propyltrimethylene dicarbamate, 2-methyl-2-propyl-1,3-propanediol dicarbamate (Equanil, Miltown), is officiallyindicated as an antianxiety agent. It is also a sedative–hypnotic agent. It has several overall pharmacological properties resembling those of benzodiazepines and barbiturates.The mechanism of action underlying anxiolytic effectsis unknown but may involve effects on conductivity inspecific brain areas.It does not appear to act through effectson GABAergic systems.The drug is effective againstabsence seizures and may worsen generalized tonic–clonicseizures.
공기와 물의 반응
Insoluble in water.
반응 프로필
Meprobamate is a carbamate ester. Carbamates are chemically similar to, but more reactive than amides. Like amides they form polymers such as polyurethane resins. Carbamates are incompatible with strong acids and bases, and especially incompatible with strong reducing agents such as hydrides. Flammable gaseous hydrogen is produced by the combination of active metals or nitrides with carbamates. Strongly oxidizing acids, peroxides, and hydroperoxides are incompatible with carbamates.
위험도
Central nervous system depressant, use
restricted by law.
화재위험
Flash point data for Meprobamate are not available; however, Meprobamate is probably combustible.
Clinical Use
Meprobamate is also a centrally acting skeletal musclerelaxant. The agents in this group find use in several conditions,such as strains and sprains that may produce acutemuscle spasm. They have interneuronal blocking propertiesat the level of the spinal cord, which are said to bepartly responsible for skeletal muscle relaxation.Also,the general CNS depressant properties they possess maycontribute to, or be mainly responsible for, the skeletalmuscle relaxant activity.
Safety Profile
Human poison by
unspecified routes. Moderately toxic to
humans and experimentally by ingestion.
Experimental poison by intravenous,
intraperitoneal, and subcutaneous routes. An
experimental teratogen. Human systemic
effects by ingestion: coma, blood pressure
decrease, regional or general arteriolar
constriction, dyspnea, cyanosis, respiratory
depression, nausea or vomiting, and allergic
skin dermatitis. Experimental reproductive
effects. Mutation data reported. Implicated
in aplastic anemia. Used as a tranquilizer.
When heated to decomposition it emits
toxic fumes of NOx.
Purification Methods
Crystallise it from hot water, aqueous EtOH (m 104-105.5o) or xylene (m 104.1-105.3o). It can be an addictive drug. [Beilstein 3 IV 73.]
메프로바메이트 준비 용품 및 원자재
원자재
준비 용품
