Aminophylline is a 2/1 mixture of theophylline and
ethylenediamine. It caused contact dermatitis in
industrial plants, in pharmacists, and in nurses.
Ethylenediamine is the sensitizer, and patch testing is
generally positive to both ethylenediamine and aminophylline,
but negative to theophylline.
화학적 성질
white to slightly yellowish powder
용도
Aminophylline is a bronchodilator and a non-selective phosphodiesterase (PDE) inhibitor.
World Health Organization (WHO)
Aminophylline, the ethylenediamine salt of theophylline, was
introduced many years ago as a treatment for asthma and is listed in the 8th WHO
Model List of Essential Drugs. It has been recognized for some 10 years that
aminophylline preparations are not interchangeable because bioavailability can
vary considerably. The resulting variability in drug absorption can lead to adverse
effects including irritation of the mucosa. Allergic reation can also be an adverse
effect of aminophylline. Theophylline functions similarly but is considered less of
an irritant.
위험도
Cardiovascular and respiratory collapse.
색상 색인 번호
This drug is a 2:1 mixture of the alkaloid theophylline
and ethylenediamine (see below). It caused contact
dermatitis in industrial plants, pharmacists, and nurses.
Ethylenediamine is the sensitizer and patch testing is
generally positive to both ethylenediamine and aminophylline
and negative to theophylline.
