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다이메틸 푸마르산

다이메틸 푸마르산
다이메틸 푸마르산 구조식 이미지
카스 번호:
624-49-7
한글명:
다이메틸 푸마르산
동의어(한글):
디메틸푸마레이트;다이메틸푸마르산;다이메틸푸마르산(DIMETHYLFUMARATE)
상품명:
Dimethyl fumarate
동의어(영문):
tl353;BG-12);Dimethylfumarat;Methyl fumarate;imethylfumarate;BIS-METHYL ESTER;dimethylfumalate;TwoMethylfuMarate;Dimethylefumarate;DIMETHYL FUMARATE
CBNumber:
CB6712800
분자식:
C6H8O4
포뮬러 무게:
144.13
MOL 파일:
624-49-7.mol

다이메틸 푸마르산 속성

녹는점
102-106 °C (lit.)
끓는 점
192-193 °C (lit.)
밀도
1,37 g/cm3
증기압
5 hPa (25 °C)
굴절률
1.4062 (estimate)
인화점
192-193°C
저장 조건
Store below +30°C.
용해도
1.6g/l
물리적 상태
Liquid
색상
Clear colorless to faintly yellow
수소이온지수(pH)
4.0-6.0 (10g/l, H2O, 20℃)suspension
수용성
Soluble in water (1.6 mg/ml at 20°C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25°C), DMSO (29 mg/ml at 25°C), and DMF (~12 mg/ml).
Merck
14,4287
BRN
774590
안정성
Stable. Incompatible with acids, bases, oxidizing agents, reducing agents.
CAS 데이터베이스
624-49-7(CAS DataBase Reference)
NIST
2-Butenedioic acid (E)-, dimethyl ester(624-49-7)
EPA
2-Butenedioic acid (2E)-, 1,4-dimethyl ester (624-49-7)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 21-38-41-43-36/37/38-36/38
안전지침서 26-36/37/39-36/37
유엔번호(UN No.) UN 3077 9 / PGIII
WGK 독일 1
RTECS 번호 EM6125000
TSCA Yes
HS 번호 29171990
유해 물질 데이터 624-49-7(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 2240 mg/kg LD50 dermal Rabbit 1250 mg/kg
기존화학 물질 KE-11412
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H312 피부와 접촉하면 유해함 급성 독성 물질 - 경피 구분 4 경고 P280,P302+P352, P312, P322, P363,P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
H411 장기적 영향에 의해 수생생물에 유독함 수생 환경유해성 물질 - 만성 구분 2
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P304+P340 흡입하면 신선한 공기가 있는 곳으로 옮기고 호흡하기 쉬운 자세로 안정을 취하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.
NFPA 704
0
1 0

다이메틸 푸마르산 MSDS


Dimethyl fumarate

다이메틸 푸마르산 C화학적 특성, 용도, 생산

개요

In March 2013, the US FDA approved dimethyl fumarate for the treatment of relapsing forms of multiple sclerosis (MS). Dimethyl fumarate is the newest oral therapeutic for MS. While its mechanism is not completely understood, dimethyl fumarate increases anti-inflammatory cytokines (IL-10, IL-4, and IL-6), decreases proinflammatory cytokines (IL-1β, IL-6, and TNF-α), and activates the Nrf2 pathway to protect neuronal cells. Nrf2 is activated by covalent bond-forming electrophiles such as dimethyl fumarate, a Michael acceptor. Dimethyl fumarate has been used for the treatment of psoriasis in Europe since 1994 and has a favorable long-term safety profile. An exploratory study in patients with relapsing remitting MS showed significant reductions in MS lesions after 18 weeks of treatment with 720 mg/day of dimethyl fumarate. Evaluation of dimethyl fumarate in a mouse experimental autoimmune encephalomyelitis model of MS resulted in reduced spinal cord macrophage inflammation. Dimethyl fumarate is obtained in high purity by esterification of fumaric acid with methanol and catalytic sulfuric acid.

화학적 성질

fine white crystalline powder

Originator

Biogen Idec (United States)

용도

immunomodulator

용도

trans-1,2-Ethylenedicarboxylic Acid is used in cycloaddition reactions involving ylides, benzenes and amino acids.

용도

Dimethyl fumarate acts as an immunomodulator. It is also used in cycloaddition reactions involving ylides, benzenes and amino acids. It is added to food grains,tobacco,leather and preservation. Clothing

정의

ChEBI: An enoate ester resulting from the formal condensation of both carboxy groups of fumaric acid with methanol. Used for treatment of adults with relapsing forms of multiple sclerosis.

상표명

Tecfidera

Synthesis Reference(s)

Synthetic Communications, 21, p. 223, 1991 DOI: 10.1080/00397919108020815
The Journal of Organic Chemistry, 55, p. 329, 1990 DOI: 10.1021/jo00288a056

일반 설명

Dimethyl fumarate is a novel oral therapeutic agent, which can be used for patients suffering from relapsing-remitting multiple sclerosis. It shows an effective inhibition of mould in bread and can also serve as a potential candidate for the treatment of psoriasis, a chronic autoimmune condition.

색상 색인 번호

Dimethylfumarate, a strong irritant, is used as an industrial wide spectrum biocide in Asia and mainly in China, for textiles, leather, seeds, food, and cosmetic ingredients. It provoked a worldwide epidemic of severe contact dermatitis, initially from Chinese sofas sold in Finland, Great Britain, and France. It also induced severe burning and contact allergy due to shoes, and to contaminated clothing as well. This chemical, presents as is (white powder) or as tablets contained in little bags disposed in/or around the materials to protect, progressively evaporates and contaminates the environment. It is forbidden in the European Union since 2008

다이메틸 푸마르산 준비 용품 및 원자재

원자재

준비 용품


다이메틸 푸마르산 공급 업체

글로벌( 434)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Henan DaKen Chemical CO.,LTD.
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info@dakenchem.com China 15424 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Zjartschem
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+86-571-87063838 jocelynpan@zjarts.com CHINA 997 58
career henan chemical co
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sales@coreychem.com China 29954 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 19969 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5941 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1275 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58

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