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tert-Butyl 1-piperazinecarboxylate

tert-Butyl 1-piperazinecarboxylate 구조식 이미지

카스 번호:: 57260-71-6

상품명:: tert-Butyl 1-piperazinecarboxylate

동의어(영문):: BOC-PIPERAZINE;N-BOC-PIPERAZINE;PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-BOC-PIPERAZINE;1-(TERT-BUTOXYCARBONYL)PIPERAZINE;N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE;PIBOC;BOC-PAZ;N-Boc Piperizene;BUTTPARK 52\11-35

CBNumber:: CB8268275

분자식:: C9H18N2O2

포뮬러 무게:: 186.25

MOL 파일:: 57260-71-6.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 840

tert-Butyl 1-piperazinecarboxylate 속성

녹는점: 43-47 °C(lit.)

끓는 점: 98-100

밀도: 1.030±0.06 g/cm3(Predicted)

인화점: >230 °F

저장 조건: Keep in dark place,Inert atmosphere,2-8°C

용해도: DMSO에 용해됨

산도 계수 (pKa): 8.45±0.10(Predicted)

물리적 상태: 저융점 결정질 덩어리

색상: 흰색에서 밝은 노란색

수용성: 에틸 아세테이트, 메탄올 및 물에 용해됩니다.

감도: Air Sensitive

BRN: 879985

InChIKey: CWXPZXBSDSIRCS-UHFFFAOYSA-N

CAS 데이터베이스: 57260-71-6(CAS DataBase Reference)

NIST: T-butyl 1-piperaziencarboxylate(57260-71-6)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xi
위험 카페고리 넘버	36/37/38
안전지침서	26-36
유엔번호(UN No.)	3263
WGK 독일	3
F 고인화성물질	3-10-34
위험 등급	IRRITANT
HS 번호	29335995

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P264	취급 후에는 손을 철저히 씻으시오.
P264	취급 후에는 손을 철저히 씻으시오.
P271	옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

NFPA 704

	1
2		0

tert-Butyl 1-piperazinecarboxylate C화학적 특성, 용도, 생산

화학적 성질

Waxy Solid

용도

1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.

주요 응용

Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.

일반 설명

1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K₃PO₄ (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.

tert-Butyl 1-piperazinecarboxylate 준비 용품 및 원자재

원자재

에틸알코올 디 -Tert- 부틸 디 카보네이트 피페라진 디클로로메탄 메틸알콜 수산화나트륨 석유 에테르

준비 용품

TERT-BUTYL 4-(5-FORMYLPYRID-2-YL)PIPERAZINE-1-CARBOXYLATE PIPERAZINE-1,4-DICARBOXYLIC ACID TERT-BUTYL ESTER METHYL ESTER 1-(2-Methoxyethyl)piperazine 1-(CYCLOPROPYLMETHYL)PIPERAZINE tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97% 1-Boc-4-(2-formylphenyl)piperazine 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE 1-(2-PYRAZINYL)-PIPERAZINE 1-(3-Chlorphenyl)piperazine N-Boc-4-(Cyclopropylmethyl)piperazine 1303512-02-8 4-(2-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Trimetazidine

tert-Butyl 1-piperazinecarboxylate 공급 업체

글로벌( 840)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Anhui Dexinjia Biopharm Co., Ltd	+86-531-82375818 +86-15064153060	alice@jndxj.com	China	309	58
Nanjing Sinoda Biological Technology Co., Ltd	+8613401983379	sales@njmcn.cn	CHINA	74	58
BTC pharm India	+918790379245	banny.janga@btcpharm.com	India	1269	58
Guangzhou Tosun Pharmaceutical Limited	+8618922120635	sales@toref-standards.com	China	1000	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Anhui Zhongda Biotechnology Co., Ltd	+8619956560829	justine@zhongda-biotech.com	China	300	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	7845	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	951	58

tert-Butyl 1-piperazinecarboxylate 관련 검색:

레스메트린 1-아미노에틸피페라진 브푸로페진 피페라진 다이부틸푸탈레이트 부틸 올레인산염 시할로폽부틸 tert-부틸알코올 2-Ethylhexyl ferulate Piperacillin N-Carbobenzyloxyglycine BOC-PIPERAZINE HYDROCHLORIDE 4-(4-fluoro-3-(piperazine-1-carbonyl)benzyl)phthalazin-1(2H)-one PIPERAZINE DIHYDROCHLORIDE 3-((4-Oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid 1,1,3,3-Tetramethylurea 1-Hydroxybenzotriazole 5-Bromo-2-fluorobenzonitrile