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tert-Butyl 1-piperazinecarboxylate

tert-Butyl 1-piperazinecarboxylate Struktur
57260-71-6
CAS-Nr.
57260-71-6
Englisch Name:
tert-Butyl 1-piperazinecarboxylate
Synonyma:
BOC-PIPERAZINE;N-BOC-PIPERAZINE;PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-BOC-PIPERAZINE;1-(TERT-BUTOXYCARBONYL)PIPERAZINE;N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE;PIBOC;BOC-PAZ;N-Boc Piperizene;BUTTPARK 52\11-35
CBNumber:
CB8268275
Summenformel:
C9H18N2O2
Molgewicht:
186.25
MOL-Datei:
57260-71-6.mol
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tert-Butyl 1-piperazinecarboxylate Eigenschaften

Schmelzpunkt:
43-47 °C(lit.)
Siedepunkt:
98-100
Dichte
1.030±0.06 g/cm3(Predicted)
Flammpunkt:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit
Soluble in DMSO
pka
8.45±0.10(Predicted)
Aggregatzustand
Low Melting Crystalline Mass
Farbe
White to light yellow
Wasserlöslichkeit
Soluble in ethyl acetate, methanol and water.
Sensitive 
Air Sensitive
BRN 
879985
InChIKey
CWXPZXBSDSIRCS-UHFFFAOYSA-N
CAS Datenbank
57260-71-6(CAS DataBase Reference)
NIST chemische Informationen
T-butyl 1-piperaziencarboxylate(57260-71-6)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-36
RIDADR  3263
WGK Germany  3
F  3-10-34
HazardClass  IRRITANT
HS Code  29335995
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P271 Nur im Freien oder in gut belüfteten Räumen verwenden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

tert-Butyl 1-piperazinecarboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

Waxy Solid

Verwenden

1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.

Application

Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.

Allgemeine Beschreibung

1-Boc-piperazine is an N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K3PO4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free N-Boc protection catalyzed by iodine.

tert-Butyl 1-piperazinecarboxylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Ethanol Di(tert-butyl)carbonat Piperazin Dichlormethan Methanol Natriumhydroxid Ligroin

Downstream Produkte

TERT-BUTYL 4-(5-FORMYLPYRID-2-YL)PIPERAZINE-1-CARBOXYLATE PIPERAZINE-1,4-DICARBOXYLIC ACID TERT-BUTYL ESTER METHYL ESTER 1-(2-Methoxyethyl)piperazine 1-(CYCLOPROPYLMETHYL)PIPERAZINE tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97% 1-Boc-4-(2-formylphenyl)piperazine 1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE 1-Piperazinylpyrazin 1-(m-Chlorphenyl)piperazin N-Boc-4-(Cyclopropylmethyl)piperazine 1303512-02-8 4-(2-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 4-(3-AMINO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Trimetazidin

tert-Butyl 1-piperazinecarboxylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 840)Lieferanten
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Anhui Dexinjia Biopharm Co., Ltd
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Nanjing Sinoda Biological Technology Co., Ltd
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 banny.janga@btcpharm.com India 1269 58
Guangzhou Tosun Pharmaceutical Limited
+8618922120635
 sales@toref-standards.com China 1000 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578
 sales@hbmojin.com China 12456 58
Shaanxi Haibo Biotechnology Co., Ltd 		+undefined18602966907
 qinhe02@xaltbio.com China 1000 58
Anhui Zhongda Biotechnology Co., Ltd 		+8619956560829
 justine@zhongda-biotech.com China 300 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858
 daisy@anhuiruihan.com China 994 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652
 info@fdachem.com China 7845 58
hebei hongtan Biotechnology Co., Ltd 		+86-86-1913198-3935 +8617331935328
 sales03@chemcn.cn China 951 58

57260-71-6()Verwandte Suche:

Buprofezin Piperazin Dibutylphthalat [2S-[2α,5α,6β(S*)]]-6-[[[[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carbonsure Butyloleat Resmethrin (ISO) 2-Piperazin-1-ylethylamin N-Benzyloxycarbonylglycin Cyhalofop-butyl Piperazine ferulate 2-Methylpropanol-2 1-Hydroxybenzotriazol Tetramethylharnstoff Piperazindihydrochlorid Piperidin-4-carboxamid Dimethylphosphonat Cyclopropancarbonylchlorid Piperidin-2-carbonsure
  • 1-Boc-piperazine,99%
  • 1-(tert-Butyloxycarbonyl)piperazine
  • 1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
  • 1-Piperazinecarboxylic Acid tert-Butyl Este
  • N-(tert-Butoxycarbonyl)piperazine 98%
  • Piperazine, N1-BOC protected
  • tert-Butyl 2-piperazinecarboxylate
  • N-(T-BUTYLOXYCARBONYL)-PIPERAZINE
  • BUTTPARK 52\11-35
  • BOC-PAZ
  • 1-(tert-Butoxycarbonyl)piperazine~tert-Butyl 1-piperazinecarboxylate
  • 1-BOC-PIPERAZINE, PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 1-N-BOC-PIPERAZINE 99+%
  • Piperazine, N1-BOC protected 98%
  • 1-BOC-PIPERAZINE hydrochloride
  • N-Boc-piperazine [N-(tert-Butoxycarbonyl)-piperazine]
  • 1-Boc-piperazine >=98.0% (GC)
  • 1-Boc-piperazine 97%
  • N - bok - piperazine
  • 1-Boc-piperazine≥ 99%(GC)
  • tert-Butyl 1-piperazinecarboxyl
  • N-Boc-piperazine hydrochloride
  • 1-Boc-piperazine ,98%
  • tert-Butyl 1-piperazinecarboxylate,97%
  • tert-Butyl 1-piperazinecarboxylate，1-N-Boc-Piperazine
  • 1-Boc-piperazine,tert-Butyl piperazine-1-carboxylate
  • tert-butyl piperazine-1-carboxylate(SALTDATA: FREE)
  • t-Butyl 1-piperazincarboxylate
  • TERT-BUTYL N-PIPERAZINE
  • TERT-BUTYL TETRAHYDROPYRAZINE-1(2H)-CARBOXYLATE
  • TERT-BUTYL 1-PIPERAZINECARBOXYLATE
  • RARECHEM AR PA 0026
  • PIBOC
  • N-(T-BOC)PIPERAZINE
  • N-T-BUTOXYCARBONYLPIPERAZINE
  • N-(TERT-BUTOXYCARBONYL)PIPERAZINE
  • 1-[(1,1-DiMethylethoxy)carbonyl]piperazine
  • 1-Piperazinecarboxylic Acid tert-Butyl Ester
  • N-(tert-Butoxycarbonyl)piperazine, tert-Butyl piperazine-1-carboxylate
  • tert-Butyl 1-piperazinecarboxylate, 97% 5GR
  • tert-butyl piperazine-1-carbox
  • 1,1-Dimethylethyl 1-piperazinecarboxylate
  • Tert-Butyl 1-Piperazinecarboxylate1
  • tert-Butyl 1-piperazincarboxylate
  • 1-Boc-piperazine, 98%, for synthesis
  • 1-(tert-Butoxycarbonyl)piperazine >
  • Avatrombopag Impurity 28
  • BOC-PAZ/1-Boc-piperazine
  • tert-Butyl 1-piperazinecarboxylate ISO 9001：2015 REACH
  • tert-butyl piperazine-1-carboylate
  • Tertbutylpiperzine-1-carboxylate (N-Boc-piperazine)
  • t-BUTYL PIPERZINE-1-CARBOXYLATE
  • CAS:57260-71-6 tert-Butyl 1-piperazinecarboxylate
  • 1-BOC-Piperazine extrapure, 99%
  • BOC-PIPERAZINE
  • PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • N-BOC-PIPERAZINE
  • N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE
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