말레인산클로로페니라민
|
|
말레인산클로로페니라민 속성
- 녹는점
- 130-135 °C (lit.)
- 알파
- -1～+1°(D/20℃)(c=5,DMF)
- 밀도
- 1.1984 (rough estimate)
- 굴절률
- 1.6800 (estimate)
- 인화점
- 9℃
- 저장 조건
- 2-8°C
- 용해도
- 물에 잘 녹고, 에탄올에 녹습니다(96%).
- 물리적 상태
- Solid
- 색상
- 흰색에서 거의 흰색
- 냄새
- 냄새 없는
- 수소이온지수(pH)
- 4.0～5.5 (10g/l, 25℃)
- 수용성
- 21&C에서 1~5g/100mL
- Merck
- 14,2180
- BCS Class
- 3/1
- InChIKey
- DBAKFASWICGISY-BTJKTKAUSA-N
- LogP
- 3.389 (est)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,F | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25-39/23/24/25-23/24/25-11 | ||
| 안전지침서 | 36/37/39-45-36/37-16 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | US6504000 | ||
| TSCA | Yes | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 29333990 | ||
| 독성 | LD50 orally in mice: 162 mg/kg (Smith) | ||
| 기존화학 물질 | KE-05616 |
말레인산클로로페니라민 C화학적 특성, 용도, 생산
개요
Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum. It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits. It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma. Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.화학적 성질
White Solid용도
(±)-Chlorpheniramine maleate salt has been used:- as H1 receptor antagonist to determine the receptor function
- to block the effect of compound 48/80 on plasma IGF-I
- as a standard for fast sensing and determination by sequential injector coupled with potentiometer
일반 설명
Odorless white crystalline solid or white powder with a bitter taste. pH (2% aqueous solution) 5. pH (1% aqueous solution) 4-5.공기와 물의 반응
Water soluble.반응 프로필
A halogenated amine, ester. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.화재위험
Flash point data for Chlorpheniramine maleate are not available; however, Chlorpheniramine maleate is probably combustible.Safety Profile
Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx.말레인산클로로페니라민 준비 용품 및 원자재
원자재
준비 용품
말레인산클로로페니라민 공급 업체
글로벌( 758)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085 +86-15531157085 |
abby@chuanghaibio.com | China | 8805 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 |
info@fortunachem.com | China | 5969 | 58 |
| XI'AN TIANGUANGYUAN BIOTECH CO., LTD. | +86-029-86333380 18829239519 |
sales06@tgybio.com | China | 899 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5878 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 |
sales@sdperfect.com | China | 294 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2472 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10986 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20255 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 |
admin@oudaxin.com | China | 114 | 58 |
| airuikechemical co., ltd. | +86-18353166132 +86-18353166132 |
sales02@airuikechemical.com | China | 983 | 58 |