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글리피지드

글리피지드
글리피지드 구조식 이미지
카스 번호:
29094-61-9
한글명:
글리피지드
동의어(한글):
글리피지드
상품명:
Glipizide
동의어(영문):
k4024;tk1320;Aldiab;Digrin;Glican;Glipid;Ozidia;Glidiab;Melizide;Minidiab
CBNumber:
CB9185001
분자식:
C21H27N5O4S
포뮬러 무게:
445.54
MOL 파일:
29094-61-9.mol

글리피지드 속성

녹는점
208-209°C
저장 조건
-20°C Freezer
용해도
methanol: 1.9 mg/mL
산도 계수 (pKa)
pKa 5.9 (Uncertain)
물리적 상태
solid
색상
white
Merck
14,4442
CAS 데이터베이스
29094-61-9(CAS DataBase Reference)

안전

위험품 표기 Xn,Xi
위험 카페고리 넘버 21-36/38-46-62-63
안전지침서 24/25-53-36/37-26-25
WGK 독일 3
RTECS 번호 YS7640000
F 고인화성물질 10
HS 번호 29350090
독성 LD50 in mice, rats (g/kg): >3, 1.2 i.p. (Ambrogi)

글리피지드 C화학적 특성, 용도, 생산

화학적 성질

Crystalline Solid

용도

sweetener, treatment of portoencephalopathy

용도

Labelled Glipizide . A sulfonylurea hypoglycemic agent. Used as an antidiabetic.;Labeled Glipizide, intended for use as an internal standard for the quantification of Glipizide by GC- or LC-mass spectrometry.

용도

A hypoglycemic agent that enhances insulin secretion.

정의

ChEBI: An N-sulfonylurea that is glyburide in which the (5-chloro-2-methoxybenzoyl group is replaced by a (5-methylpyrazin-2-yl)carbonyl group. An oral hypoglycemic agent, it is used in the treatment of type 2 diabetes mellitus.

상표명

Glucotrol (Pfizer).

일반 설명

Glipizide is N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl-2-pyrazinecarboxamide;this compound can also be named as the urea—seepreceding discussion (Glucotrol, generic). In the UnitedStates, combinations are available with metformin (Metaglip,generic; tablets, mg glipizide/mg metformin as hydrochloride:2.5/250, 2.5/500, 5/500). Extended-release tablets are available(Glucotrol XL, generic). The pyrazine moiety within thisstructure renders the molecule significantly more hydrophilicthan the similar molecule glyburide, albeit also moderatelyless potent on a dosage as well as target-level basis.

일반 설명

Glipizide, 1-cyclohexyl-3-[[p-(2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea(Glucotrol), is an off-white, odorless powder with a pKa of5.9. It is insoluble in water and alcohols, but soluble in 0.1 NNaOH. Even though on a weight basis, it is approximately100 times more potent than tolbutamide, the maximal hypoglycemiceffects of these two agents are similar. It is rapidlyabsorbed on oral administration, with a serum half-life of 2 to4 hours, whereas the hypoglycemic effects range from 12 to24 hours. Metabolism of glipizide is generally through oxidationof the cyclohexane ring to the p-hydroxy and m-hydroxymetabolites. A minor metabolite that occurs involves theN-acetyl derivative, which results from the acetylation of theprimary amine following hydrolysis of the amide system byamidase enzymes.

일반 설명

Structurally, glipizide, 1-cyclohexyl-3-[[p-[2(methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea(Glucotrol), is a cyclohexylsulfonylurea analog similar toacetohexamide and glyburide. The drug is absorbed rapidlyon oral administration. Its serum half-life is 2 to 4 hours, andit has a hypoglycemic effect that ranges from 12 to 24 hours.

Veterinary Drugs and Treatments

Glipizide may be of benefit in treating cats with type II diabetes if they have a population of functioning beta cells. It has been suggested that there are two situations when glipizide can be recommended, 1) If an owner refuses to consider using insulin usually due to a fear of needles, and 2) the cat appears to be relatively well controlled on quite small doses of insulin and the owner would strongly prefer to no longer give insulin (Feldman 2005b).
While glipizide potentially could be useful in treating canine patients with type II or III diabetes, however, by the time dogs present with hyperglycemia, they are absolutely or relatively insulinopenic and glipizide would unlikely be effective.

글리피지드 준비 용품 및 원자재

원자재

준비 용품


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