3-아세틸피리딘
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3-아세틸피리딘 속성
- 녹는점
- 11-13 °C (lit.)
- 끓는 점
- 220 °C (lit.)
- 밀도
- 1.102 g/mL at 25 °C (lit.)
- 증기압
- 0.3Pa at 20℃
- 굴절률
- n
20/D 1.534(lit.)
- 인화점
- 302 °F
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 산도 계수 (pKa)
- pK1: 3.256(+1) (25°C)
- 물리적 상태
- 액체
- 색상
- 무색~황색으로 투명함
- Specific Gravity
- 1.102
- 수소이온지수(pH)
- 6.5-7.5 (H2O, 20℃)
- 냄새
- 디프로필렌 글리콜 중 1.00%. 달콤하고 고소한 드라이 호손 페놀릭 우디 팝콘
- ?? ??
- 견과류
- 수용성
- 뜨거운 물에 용해됨
- Merck
- 14,6116
- JECFA Number
- 1316
- BRN
- 107751
- InChIKey
- WEGYGNROSJDEIW-UHFFFAOYSA-N
- LogP
- 0.34 at 13℃
- CAS 데이터베이스
- 350-03-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,Xi,Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25-36/38-36/37/38-20/21/22 | ||
| 안전지침서 | 45-37/39-28A-26-36 | ||
| 유엔번호(UN No.) | UN 2810 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | OB5425000 | ||
| F 고인화성물질 | 8-10 | ||
| 위험 참고 사항 | Irritant | ||
| TSCA | Yes | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | II | ||
| HS 번호 | 29333999 | ||
| 독성 | LD50 orl-rat: 46 mg/kg JACTDZ 1,681,92 |
3-아세틸피리딘 C화학적 특성, 용도, 생산
화학적 성질
clear colorless to yellow liquid출처
Reported found in roasted filberts, beer, brandy, coffee, malt and wheaten bread.용도
3-Acetylpyridine used as an intermediate for the synthesis of risedronate sodium, inhibitor of bone resorption. It is also used in perfumery.제조 방법
Dry distillation of calcium nicotinate with calcium acetate.정의
It is a nicotinic acidantagonist.Safety Profile
Poison by ingestion. Moderately toxic by intraperitoneal routeMutation data reported. A flammable liquid. When heated to decomposition emits toxic fumes of NOx,. See also KETONESPurification Methods
It is purified by dissolving in HCl, extracting with Et2O to remove the possible impurity of nicotinic acid, basified with NaOH and extracted with Et2O. The dried extract is filtered, evaporated and the residual oil is distilled. If the NMR spectrum indicates further impurities, then convert it to the phenylhydrazone (m 137o, yellow needles from EtOH). This is hydrolysed with HCl [Engler & Kiby Chem Ber 22 597 1889], the phenylhydrazine HCl is removed by filtration, NaNO2 is added, the solution is basified with aqueous NaOH and extracted with Et2O as before and distilled at atmospheric pressure to give 3-acetylpyridine as a colourless oil. Purification can also be achieved by shaking with 50% aqueous KOH, extracting with Et2O, drying the extract and distilling it at atmospheric pressure or in vacuo. [Kloetzel & Chubb J Am Chem Soc 79 4226 1957.] The hydrochloride has m 180-181o (from MeOH/EtOH), the picrate has m 133.8-134.8o (from H2O), and the phenylhydrazone has m 137o (129-130o)(needles, from EtOH) [Webb & Webb J Am Chem Soc 71 2285 1949]. The ketoxime has m 112o (from EtOH or *C6H6). [Strong & McElvain J Am Chem Soc 55 816 1933, Kolloff & Hunter J Am Chem Soc 63 490 1941, Beilstein 21/7 V 394.]3-아세틸피리딘 준비 용품 및 원자재
원자재
준비 용품
5-(Pyridin-3-yl)-1H-pyrazole-3-carboxamide ,97%
3-ACETYL-2-CHLOROPYRIDINE
5-PYRIDIN-3-YL-1H-PYRAZOLE-3-CARBOXYLIC ACID
1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one
ETHYL 3-PYRIDYLACETATE
3-(2-Bromoacetyl)pyridine hydrobromide
5-(PYRIDIN-3-YL)-1H-PYRAZOLE-3-CARBOXYLIC ACID ETHYL ESTER
4-(Pyridin-3-yl)pyrimidin-2-amine
5-(Pyridin-3-yl)-1H-pyrazole-3-carbohydrazide ,97%
2-Amino-3-acetylpyridine
5-Acetyl-2-cyanopyridine
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid
1-(1-Oxido-3-pyridinyl)-ethanone
1H-Pyrrole-2-carboxylicacid,4-formyl-,methylester(9CI)
4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid methyl ester
3-아세틸피리딘 공급 업체
글로벌( 764)공급 업체
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| Terma Medicare India Pvt.,Ltd | +8613916485955 |
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| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
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| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
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| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
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| Hi-Tech Chemistry Corp | 0519-86626038 |
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| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
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| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 |
chloewu@chicopharm.cn | CHINA | 341 | 58 |