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심바스타틴

심바스타틴
심바스타틴 구조식 이미지
카스 번호:
79902-63-9
한글명:
심바스타틴
동의어(한글):
심바스타틴
상품명:
Simvastatin
동의어(영문):
ZOCOR;Denan;Eucor;Lipex;MK-733;Rechol;Simcor;Zocord;Simlup;Zorced
CBNumber:
CB9716324
분자식:
C25H38O5
포뮬러 무게:
418.57
MOL 파일:
79902-63-9.mol

심바스타틴 속성

녹는점
139 °C
알파
D25 +292° (c = 0.5% in acetonitrile)
저장 조건
0-6°C
용해도
DMSO: ≥20mg/mL
물리적 상태
solid
색상
white
optical activity
[α]/D +275±25°, c = 1 in acetonitrile
Merck
14,8539
CAS 데이터베이스
79902-63-9(CAS DataBase Reference)
NIST
Simvastatin(79902-63-9)

안전

위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36-24/25
유엔번호(UN No.) 3077
WGK 독일 2
RTECS 번호 EK7798000
위험 등급 9
포장분류 III
HS 번호 29322090
유해 물질 데이터 79902-63-9(Hazardous Substances Data)

심바스타틴 C화학적 특성, 용도, 생산

개요

Simvastatin is an once-daily hypolipemic, an analog of lovastatin indicated for the treatment of atherosclerosis. In patients with Type IN or IIB hypercholesterolemia, simvastatin reportedly produces significant reductions in total serum cholesterol, LDL, mglycerides and apolipoprotein-B, while HDL and apolipoprotein-A levels are increased.

화학적 성질

White Powder

Originator

Merck (USA)

용도

A HMGCR inhibitor and anti-proliferative agent.

용도

Simvastatin is a synthetic derivate of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.

용도

antiinflammatory

용도

Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the dr ug, is sold under the trade name Zocor.

용도

Simvastatin is semi-synthetic, slightly more hydrophobic, analogue of lovastatin. Like lovastatin, simvastatin is a specific inhibitor of HMG-CoA reductase and is used therapeutically to reduce LDL cholesterol. More recently, the statins have become important biochemical probes in cell biology. Their involvement in many events can be correlated to their primary mode of action, however, the mechanism of action of many other effects is less apparent.

용도

anti-hyperlipoproteinemic, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor

정의

ChEBI: A carbobicyclic compound that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.

상표명

Zocor (Merck);Zocord.

일반 설명

Simvastatin, 2,2-dimethyl butanoic acid,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2-pyran-2-yl)ethyl]-1-naphthalenyl ester(Zocor), is an analog of lovastatin. These two drugs havemany similar properties. Both drugs, in the prodrug form,reach the liver unchanged after oral administration, wherethey undergo extensive metabolism to several open-ring hydroxyacids, including the active -hydroxy acids. They arealso highly bound to plasma proteins. These actions makethe bioavailability of simvastatin rather poor but better thanthat of lovastatin, which has been estimated to be 5%.

생물학적 활성

HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, and anticancer and anti-inflammatory activity.

심바스타틴 준비 용품 및 원자재

원자재

준비 용품


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