심바스타틴
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심바스타틴 속성
- 녹는점
- 127-132 °C (lit.)
- 알파
- D25 +292° (c = 0.5% in acetonitrile)
- 끓는 점
- 564.9±50.0 °C(Predicted)
- 밀도
- 1.11±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO: ≥20mg/mL
- 산도 계수 (pKa)
- 13.49±0.40(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 하얀색
- optical activity
- [α]/D +275±25°, c = 1 in acetonitrile
- Merck
- 14,8539
- BCS Class
- 2
- 안정성
- 공급된 상태로 2년 동안 안정적입니다. DMSO 또는 에탄올 용액은 -20°C에서 최대 2개월 동안 보관할 수 있습니다.
- CAS 데이터베이스
- 79902-63-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36-24/25 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | EK7798000 | ||
| HS 번호 | 29322090 | ||
| 유해 물질 데이터 | 79902-63-9(Hazardous Substances Data) |
심바스타틴 C화학적 특성, 용도, 생산
개요
Simvastatin is an once-daily hypolipemic, an analog of lovastatin indicated for the treatment of atherosclerosis. In patients with Type IN or IIB hypercholesterolemia, simvastatin reportedly produces significant reductions in total serum cholesterol, LDL, mglycerides and apolipoprotein-B, while HDL and apolipoprotein-A levels are increased.화학적 성질
White Powder용도
Simvastatin is a synthetic derivate of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.정의
ChEBI: A carbobicyclic compound that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.일반 설명
Simvastatin, 2,2-dimethyl butanoic acid,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2-pyran-2-yl)ethyl]-1-naphthalenyl ester(Zocor), is an analog of lovastatin. These two drugs havemany similar properties. Both drugs, in the prodrug form,reach the liver unchanged after oral administration, wherethey undergo extensive metabolism to several open-ring hydroxyacids, including the active -hydroxy acids. They arealso highly bound to plasma proteins. These actions makethe bioavailability of simvastatin rather poor but better thanthat of lovastatin, which has been estimated to be 5%.생물학적 활성
HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, and anticancer and anti-inflammatory activity.심바스타틴 준비 용품 및 원자재
원자재
N,N-다이메틸폼아마이드
터트-뷰틸클로로다이메틸실란
사이클로헥세인
모노부틸아민
로바스타틴
메틸알콜
Lithium alkyls
요오드 메탄
부틸리튬
피롤리딘
1,3-프로판디올,2-(2,2-디에톡시에틸)-,모노아세테이트,(R)-
페닐붕산
준비 용품
심바스타틴 공급 업체
글로벌( 761)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| HUARONG(GUANGDONG) PHARMACEUTICAL CO.,LTD | +86-19925801629 +86-19925801629 |
eric@huarongpharma.com | China | 241 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085 +86-15531157085 |
abby@chuanghaibio.com | China | 8806 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12820 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 |
sarah@tnjone.com | China | 1143 | 58 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21631 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3009 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29863 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |