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4-아미노피리딘

4-아미노피리딘
4-아미노피리딘 구조식 이미지
카스 번호:
504-24-5
한글명:
4-아미노피리딘
동의어(한글):
4-아미노피리딘;아비트롤;팜프리딘;염화벤질(C12-C16)알킬다이메틸암모늄
상품명:
4-Aminopyridine
동의어(영문):
4APY;4-AP;mi-w-3;AMpyra;EL 970;avitrol;vmi10-3;Neurelan;Prc 1237;VMI 10-3
CBNumber:
CB9853687
분자식:
C5H6N2
포뮬러 무게:
94.11
MOL 파일:
504-24-5.mol

4-아미노피리딘 속성

녹는점
157 °C
끓는 점
273 °C(lit.)
밀도
1.26
굴절률
1.5560 (estimate)
인화점
156°C
저장 조건
0-6°C
용해도
H2O: soluble50mg/mL, clear, colorless
산도 계수 (pKa)
9.114(at 25℃)
물리적 상태
Crystalline Powder, Solid or Crystals
색상
White to faint grey to light yellow
수용성
Soluble in water(112 g/L at 20 deg C). Soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. Soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.
Merck
14,3933
BRN
105782
InChIKey
NUKYPUAOHBNCPY-UHFFFAOYSA-N
CAS 데이터베이스
504-24-5(CAS DataBase Reference)
NIST
4-Pyridinamine(504-24-5)
EPA
4-Pyridinamine(504-24-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T+,N,T,Xi
위험 카페고리 넘버 28-36/37/38-51/53-23/24/25
안전지침서 26-36/37/39-45-60-61-37/39-28A-1
유엔번호(UN No.) UN 2671 6.1/PG 2
WGK 독일 3
RTECS 번호 US1750000
F 고인화성물질 8-21
자연 발화 온도 640 °C
위험 참고 사항 Toxic/Irritant
TSCA Yes
위험 등급 6.1
포장분류 II
HS 번호 29333999
유해 물질 데이터 504-24-5(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 21 mg/kg
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H300 삼키면 치명적임 급성 독성 물질 - 경구 구분 1,2 위험 P264, P270, P301+P310, P321, P330,P405, P501
H311 피부와 접촉하면 유독함 급성 독성 물질 - 경피 구분 3 위험 P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
H370 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재) 특정 표적장기 독성 - 1회 노출 구분 1 위험 P260, P264, P270, P307+P311, P321,P405, P501
H372 장기간 또는 반복 노출되면 장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴 특정 표적장기 독성 - 반복 노출 구분 1 위험 P260, P264, P270, P314, P501
H401 수생생물에 유독함 수생 환경유해성 물질 - 급성 구분 2 P273, P501
H411 장기적 영향에 의해 수생생물에 유독함 수생 환경유해성 물질 - 만성 구분 2
예방조치문구:
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P391 누출물을 모으시오.
P301+P310 삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P302+P352 피부에 묻으면 다량의 물로 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P307+P311 노출된 경우,독성 물질 센터 또는 의사에게 전화하기
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

4-아미노피리딘 MSDS


4-Aminopyridine

4-아미노피리딘 C화학적 특성, 용도, 생산

용도

4-AP는 탈수초성 시신경병 환자의 시력을 개선시키는 데 유용하다.

개요

Dalfampridine (also referred to as 4-AP) is the first drug approved by the FDA to improve walking in patients with multiple sclerosis (MS). Dalfampridine is a voltage-gated potassium channel blocker that readily penetrates the CNS and increases the conduction and duration of action potential across nerve fibers resulting in enhanced functionality as observed in the walking speed of MS patients.
From a safety perspective, seizure was the most important adverse event from various dalfampridine clinical trials. Therefore, dalfampridine is contraindicated in patients with a history of seizures. Since dalfampridine is primarily excreted by the kidney as unchanged drug, it is also contraindicated in patients with moderate to severe renal impairment. Assessing the overall benefit–risk profile from various clinical trials, the FDA approved dalfampridine (daily oral dose of 10 mg, b.i.d.) to improve walking in MS patients with existing gait impairment.

화학적 성질

WHITE TO SLIGHTLY YELLOW FINE CRYSTALLINE POWDER

화학적 성질

4-aminopyridine is a white crystalline solid that contains about 98% active ingredient. It is soluble in water and slightly soluble in benzene and ether. 4-Aminopyridine formulations are classifi ed by the US Environmental Protection Agency (US EPA) as restricted use pesticides (RUPs) and therefore should be purchased and used only by certifi ed and trained workers and applicators. Avitrol is available as grain baits or as a powder concentrate. It is one of the most prominent avicides. It is registered with the EPA for use against red-winged blackbirds, blackbirds in agricultural fi elds, grackles, pigeons, and sparrows around public buildings, and various birds around livestock feeding pens. Avitrol repels birds by poisoning a few members of a fl ock, causing them to become hyperactive.

화학적 성질

4-Aminopyridine is white to tan or brown crystalline material. Odorless.

Originator

Rush University Medical Center (United States)

용도

vasodilator

용도

Dalfampridine is used in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. Dalfampridine is a precursor to the drug Pinacidil.

정의

ChEBI: An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.

상표명

Neurelan (E′lan);Ampyra.

일반 설명

White crystalline material with no odor. Used as an avicide, an intermediate and as a fixer for some textile dyes.

반응 프로필

4-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

건강위험

Material may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Material affects neural transmission. In sufficient concentrations, material may cause metabolic acidosis, respiratory arrest, and cardiac arrhythmias.

건강위험

4-Aminopyridine, a pyridine compound, is an extremely effective bird poison. In agriculture, 4-AP is used as an extremely effective bird poison sold under the brand name Avitrol. It is highly toxic to all mammals including humans if dosages are exceeded, and as an experimental drug, the recommended dose data is unavailable. 4-Aminopyridine blocks

화재위험

Material may produce irritating or poisonous gases in fire. Runoff from fire control water may give off irritating or poisonous gases.

Safety Profile

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations and vomiting. When heated to decomposition it emits toxic fumes of NOx,.

잠재적 노출

Used as a chemical intermediate in pharmaceuticals; as an agricultural chemical for field crops; and as a bird repellent and poison

운송 방법

UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

Crystallise the aminopyridine from *benzene/EtOH, then recrystallise it twice from water, then crush and dry it for 4hours at 105o [Bates & Hetzer J Res Nat Bur Stand 64A 427 1960]. It has also been crystallised from EtOH, *benzene, *benzene/pet ether, toluene and sublimes in a vacuum. [Beilstein 22/9 V 106.]

비 호환성

Sodium nitrite, strong oxidizers. Avoid contact with acid anhydrides, acid chlorides; and strong acids.

폐기물 처리

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposalIncineration with nitrogen oxides removal from effluent gas.

4-아미노피리딘 준비 용품 및 원자재

원자재

준비 용품


4-아미노피리딘 공급 업체

글로벌( 392)공급 업체
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Henan DaKen Chemical CO.,LTD.
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info@dakenchem.com CHINA 21676 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
ATK CHEMICAL COMPANY LIMITED
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+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Zjartschem
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+86-571-87063838 jocelynpan@zjarts.com CHINA 997 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
NINGBO INNO PHARMCHEM CO., LTD.
13867897135
sales@nbinno.com CHINA 925 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58

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