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4-Aminopyridine

4-Aminopyridine
4-Aminopyridine
CAS No.
504-24-5
Chemical Name:
4-Aminopyridine
Synonyms
4-AP;4APY;mi-w-3;AMpyra;EL 970;vmi10-3;avitrol;Prc 1237;VMI 10-3;Neurelan
CBNumber:
CB9853687
Molecular Formula:
C5H6N2
Formula Weight:
94.11
MOL File:
504-24-5.mol

4-Aminopyridine Properties

Melting point:
157 °C
Boiling point:
273 °C(lit.)
Density 
1.26
refractive index 
1.5560 (estimate)
Flash point:
156°C
storage temp. 
0-6°C
solubility 
H2O: soluble50mg/mL, clear, colorless
pka
9.114(at 25℃)
form 
Crystalline Powder, Solid or Crystals
color 
White to faint grey to light yellow
Water Solubility 
Soluble in water(112 g/L at 20 deg C). Soluble in ethyl ether, benzene. Slightly soluble in ligroin. Very soluble in ethanol. Soluble in methanol, acetone, tetrahydrofuran, isopropanol, acetonitrile, N,N-dimethylformamide, dimethylsulfoxide, and ethanol.
Merck 
14,3933
BRN 
105782
CAS DataBase Reference
504-24-5(CAS DataBase Reference)
NIST Chemistry Reference
4-Pyridinamine(504-24-5)
EPA Substance Registry System
4-Pyridinamine(504-24-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T+,N,T,Xi
Risk Statements  28-36/37/38-51/53-23/24/25
Safety Statements  26-36/37/39-45-60-61-37/39-28A-1
RIDADR  UN 2671 6.1/PG 2
WGK Germany  3
RTECS  US1750000
8-21
Hazard Note  Toxic/Irritant
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29333999
Hazardous Substances Data 504-24-5(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger P264, P270, P301+P310, P321, P330,P405, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger P260, P264, P270, P314, P501
H401 Toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 2 P273, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P391 Collect spillage. Hazardous to the aquatic environment
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P405 Store locked up.
P501 Dispose of contents/container to..…

4-Aminopyridine price More Price(20)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 275875 4-Aminopyridine ≥99% 504-24-5 1g $29.9 2017-11-08 Buy
Sigma-Aldrich 1162454 Dalfampridine United States Pharmacopeia (USP) Reference Standard 504-24-5 200mg $347.4 2017-11-08 Buy
TCI Chemical A0414 4-Aminopyridine >99.0%(GC)(T) 504-24-5 25g $32 2017-11-08 Buy
TCI Chemical A0414 4-Aminopyridine >99.0%(GC)(T) 504-24-5 100g $102 2017-11-08 Buy
Alfa Aesar A12405 4-Aminopyridine, 98% 504-24-5 250g $196 2017-11-08 Buy

4-Aminopyridine Chemical Properties,Uses,Production

Chemical Properties

WHITE TO SLIGHTLY YELLOW FINE CRYSTALLINE POWDER

Uses

vasodilator

Uses

Dalfampridine is used in characterizing subtypes of potassium channel, and has also been used to manage some of the symptoms of multiple sclerosis, and is indicated for symptomatic improvement of walking in adults with several variations of the disease. Dalfampridine is a precursor to the drug Pinacidil.

Definition

ChEBI: An aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis.

General Description

White crystalline material with no odor. Used as an avicide, an intermediate and as a fixer for some textile dyes.

Reactivity Profile

4-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

Material may be fatal if inhaled, swallowed or absorbed through skin. Contact may cause burns to skin and eyes. Material affects neural transmission. In sufficient concentrations, material may cause metabolic acidosis, respiratory arrest, and cardiac arrhythmias.

Fire Hazard

Material may produce irritating or poisonous gases in fire. Runoff from fire control water may give off irritating or poisonous gases.

Purification Methods

Crystallise the aminopyridine from *benzene/EtOH, then recrystallise it twice from water, then crush and dry it for 4hours at 105o [Bates & Hetzer J Res Nat Bur Stand 64A 427 1960]. It has also been crystallised from EtOH, *benzene, *benzene/pet ether, toluene and sublimes in a vacuum. [Beilstein 22/9 V 106.]

4-Aminopyridine Preparation Products And Raw materials

Raw materials

Preparation Products


4-Aminopyridine Suppliers

Global( 348)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
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0371-55170693
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Mainchem Co., Ltd.
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career henan chemical co
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Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318
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ShangHai Siyan Biological Technology Co., Ltd. 021-50908862,18800375331,18721037013,QQ: 442785678, QQ:1940135426
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Hangzhou Cyanochem Co., Ltd. 17788583750
+86 571 85220831 info@cyanochem.com China 261 58
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76

View Lastest Price from 4-Aminopyridine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-23 4-Aminopyridine
504-24-5
US $63.50 / KG 1KG 98% 100ton

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